F-actin is an evolutionarily conserved damage-associated molecular pattern recognized by DNGR-1, a receptor for dead cells.

abstract：:Crosspresentation of exogenous antigens (Ags) to CD8(+) T cells by dendritic cells generally requires their entry into the cytosol. Here we show that both soluble and phagocytosed extracellular Ags accessed the cytosol via molecular components required for endoplasmic reticulum (ER)-associated degradation (ERAD). Exog...

journal_title：Immunity

authors： Ackerman AL,Giodini A,Cresswell P

更新日期：2006-10-01 00:00:00

abstract：:Stat6 is critical for IL-4-mediated Th2 cell development, but its molecular mechanism remains unclear. Here we constructed Stat6:ER, a Stat6-estrogen receptor fusion protein that can be activated by 4-hydroxy-tamoxifen, independently of IL-4 and endogenous Stat6. Retrovirus-mediated introduction of Stat6:ER into devel...

journal_title：Immunity

authors： Kurata H,Lee HJ,O'Garra A,Arai N

更新日期：1999-12-01 00:00:00

abstract：:Human cytomegalovirus inhibits peptide import into the endoplasmic reticulum (ER) by the MHC-encoded TAP peptide transporter. We identified the open reading frame US6 to mediate this effect. Expression of the 21 kDa US6 glycoprotein in human cytomegalovirus-infected cells correlates with the inhibition of peptide tran...

journal_title：Immunity

authors： Hengel H,Koopmann JO,Flohr T,Muranyi W,Goulmy E,Hämmerling GJ,Koszinowski UH,Momburg F

更新日期：1997-05-01 00:00:00

abstract：:Numerous regulatory programs have been identified that contribute to the restoration of homeostasis at the conclusion of immune responses and to safeguarding against the detrimental effects of chronic inflammation and autoimmune pathology. Malignant cells may usurp these pathways to create immunosuppressive networks t...

journal_title：Immunity

authors： Rabinovich GA,Croci DO

更新日期：2012-03-23 00:00:00

abstract：:Macrophage/neutrophil-specific IL-4 receptor alpha-deficient mice (LysM(Cre)IL-4Ralpha(-/flox)) were generated to understand the role of IL-4/IL-13 responsive myeloid cells during Type 2 immune responses. LysM(Cre)IL-4Ralpha(-/flox) mice developed protective immunity against Nippostrongylus brasiliensis accompanied by...

journal_title：Immunity

authors： Herbert DR,Hölscher C,Mohrs M,Arendse B,Schwegmann A,Radwanska M,Leeto M,Kirsch R,Hall P,Mossmann H,Claussen B,Förster I,Brombacher F

更新日期：2004-05-01 00:00:00

abstract：:Indoleamine 2,3 dioxygenase (IDO) catabolizes the amino acid tryptophan. IDO-expressing immunoregulatory dendritic cells (DCs) have been implicated in settings including tumors, autoimmunity, and transplant tolerance. However, the downstream molecular mechanisms by which IDO functions to regulate T cell responses rema...

journal_title：Immunity

authors： Munn DH,Sharma MD,Baban B,Harding HP,Zhang Y,Ron D,Mellor AL

更新日期：2005-05-01 00:00:00

abstract：:The transcription factor Pax5 is a critical regulator of B lymphocyte commitment and identity. In this issue of Immunity, Schebesta et al. (2007) demonstrate how Pax5 activates 170 different genes involved in B cell signaling, adhesion, migration, and maturation. ...

journal_title：Immunity

authors： Hagman J,Lukin K

更新日期：2007-07-01 00:00:00

abstract：:The presence of gallstones (cholelithiasis) is a highly prevalent and severe disease and one of the leading causes of hospital admissions worldwide. Due to its substantial health impact, we investigated the biological mechanisms that lead to the formation and growth of gallstones. We show that gallstone assembly essen...

journal_title：Immunity

authors： Muñoz LE,Boeltz S,Bilyy R,Schauer C,Mahajan A,Widulin N,Grüneboom A,Herrmann I,Boada E,Rauh M,Krenn V,Biermann MHC,Podolska MJ,Hahn J,Knopf J,Maueröder C,Paryzhak S,Dumych T,Zhao Y,Neurath MF,Hoffmann MH,Fuchs T

更新日期：2019-09-17 00:00:00

abstract：:T helper 17 (Th17) cells play an important role in mucosal host defense through production of the signature cytokines IL-17 and IL-22. Prostaglandin E2 (PGE2) has been shown to enhance IL-17 production by mature Th17 cells. However, when present during Th17 cell differentiation, we found that PGE2 inhibited the transc...

journal_title：Immunity

authors： Valdez PA,Vithayathil PJ,Janelsins BM,Shaffer AL,Williamson PR,Datta SK

更新日期：2012-04-20 00:00:00

abstract：:Particulate pollution is thought to function as an adjuvant that can induce allergic responses. However, the exact cell types and immunological factors that initiate the lung-specific immune responses are unclear. We found that upon intratracheal instillation, particulates such as aluminum salts and silica killed alve...

journal_title：Immunity

authors： Kuroda E,Ozasa K,Temizoz B,Ohata K,Koo CX,Kanuma T,Kusakabe T,Kobari S,Horie M,Morimoto Y,Nakajima S,Kabashima K,Ziegler SF,Iwakura Y,Ise W,Kurosaki T,Nagatake T,Kunisawa J,Takemura N,Uematsu S,Hayashi M,Aoshi T

更新日期：2016-12-20 00:00:00

abstract：:We have measured the absolute numbers of EBV-infected B cells in the peripheral blood of healthy persistently infected individuals. Single measurements on a panel of 15 healthy individuals demonstrate that the frequency varies over a wide range from 1-50 per 10(6) B cells. Repeat measurements over 1-3.5 years on sever...

journal_title：Immunity

authors： Khan G,Miyashita EM,Yang B,Babcock GJ,Thorley-Lawson DA

更新日期：1996-08-01 00:00:00

abstract：:T cell receptor (TCR) recognition of nonpeptidic and modified peptide antigens has been recently uncovered but is still poorly understood. Immunization with an H-2Kb-restricted glycopeptide RGY8-6H-Gal2 generates a population of cytotoxic T cells that express both alpha/beta TCR, specific for glycopeptide, and gamma/d...

journal_title：Immunity

authors： Speir JA,Abdel-Motal UM,Jondal M,Wilson IA

更新日期：1999-01-01 00:00:00

abstract：:Active research at the frontiers of immunology and neuroscience has identified multiple points of interaction and communication between the immune system and the nervous system. Immune cell activation stimulates neuronal circuits that regulate innate and adaptive immunity. Molecular mechanistic insights into the infla...

journal_title：Immunity

authors： Chavan SS,Pavlov VA,Tracey KJ

更新日期：2017-06-20 00:00:00

abstract：:Cyclophilin A (CypA/Ppia) is a peptidyl-prolyl isomerase (PPIase) that binds the immunosuppressive drug cyclosporine. The resulting complex blocks T cell function by inhibiting the calcium-dependent phosphatase calcineurin. To identify the native function of CypA, long suspected of regulating signal transduction, we g...

journal_title：Immunity

authors： Colgan J,Asmal M,Neagu M,Yu B,Schneidkraut J,Lee Y,Sokolskaja E,Andreotti A,Luban J

更新日期：2004-08-01 00:00:00

abstract：:Among 631 substitutions present in 90 nurse shark immunoglobulin light chain somatic mutants, 338 constitute 2-4 bp stretches of adjacent changes. An absence of mutations in perinatal sequences and the bias for one mutating V gene in adults suggest that the diversification is antigen dependent. The substitutions share...

journal_title：Immunity

authors： Lee SS,Tranchina D,Ohta Y,Flajnik MF,Hsu E

更新日期：2002-04-01 00:00:00

abstract：:Oxidative stress leads to impaired T cell activation. A central integrator of T cell activation is the actin-remodelling protein cofilin. Cofilin is activated through dephosphorylation at Ser3. Activated cofilin enables actin dynamics through severing and depolymerization of F-actin. Binding of cofilin to actin is req...

journal_title：Immunity

authors： Klemke M,Wabnitz GH,Funke F,Funk B,Kirchgessner H,Samstag Y

更新日期：2008-09-19 00:00:00

abstract：:Monobenzone is a pro-hapten that is exclusively metabolized by melanocytes, thereby haptenizing melanocyte-specific antigens, which results in cytotoxic autoimmunity specifically against pigmented cells. Studying monobenzone in a setting of contact hypersensitivity (CHS), we observed that monobenzone induced a long-la...

journal_title：Immunity

authors： van den Boorn JG,Jakobs C,Hagen C,Renn M,Luiten RM,Melief CJ,Tüting T,Garbi N,Hartmann G,Hornung V

更新日期：2016-06-21 00:00:00

abstract：:In a recent issue of Nature, Borges da Silva et al. (2018) reveal that P2RX7, a receptor for extracellular ATP, promotes CD8 T cell memory by enhancing metabolic fitness. This work links an ancient "danger" signal with long-term immunity. ...

journal_title：Immunity

authors： Greene TT,Labarta-Bajo L,Zuñiga EI

更新日期：2018-08-21 00:00:00

abstract：:The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) proteins regulate innate immunity. Although the positive regulatory impact of NLRs is clear, their inhibitory roles are not well defined. We showed that Nlrx1(-/-) mice exhibited increased expression of antiviral signaling molecules IFN-β, STAT2, O...

journal_title：Immunity

authors： Allen IC,Moore CB,Schneider M,Lei Y,Davis BK,Scull MA,Gris D,Roney KE,Zimmermann AG,Bowzard JB,Ranjan P,Monroe KM,Pickles RJ,Sambhara S,Ting JP

更新日期：2011-06-24 00:00:00

abstract：:Two families of protein tyrosine kinases (PTKs), the Src and Syk/ZAP-70 families, are required for T cell development. Lck is the major Src family member required for thymopoiesis, since there is a severe deficit of CD4+CD8+ thymocytes and mature T cells in its absence. However, some peripheral T cells are evident in ...

journal_title：Immunity

authors： van Oers NS,Lowin-Kropf B,Finlay D,Connolly K,Weiss A

更新日期：1996-11-01 00:00:00

abstract：:T cell activation induces functional changes in cell shape and cytoskeletal architecture. To facilitate the collection of dynamic, high-resolution images of activated T cells, we plated T cells on coverslips coated with antibodies to the T cell receptor (TCR). Using these images, we were able to quantitate the morphol...

journal_title：Immunity

authors： Bunnell SC,Kapoor V,Trible RP,Zhang W,Samelson LE

更新日期：2001-03-01 00:00:00

abstract：:Mutations in the NALP3/CIAS1/cryopyrin gene are linked to three autoinflammatory disorders: Muckle-Wells syndrome, familial cold autoinflammatory syndrome, and chronic infantile neurologic cutaneous and articular syndrome. NALP3, with the adaptor molecule ASC, has been proposed to form a caspase-1-activating "inflamma...

journal_title：Immunity

authors： Sutterwala FS,Ogura Y,Szczepanik M,Lara-Tejero M,Lichtenberger GS,Grant EP,Bertin J,Coyle AJ,Galán JE,Askenase PW,Flavell RA

更新日期：2006-03-01 00:00:00

abstract：:CXCR5, the receptor for B lymphocyte chemoattractant (BLC), is required for normal development of Peyer's patches, inguinal lymph nodes, and splenic follicles. To test the in vivo activity of BLC in isolation of other lymphoid organizers, transgenic mice were generated expressing BLC in the pancreatic islets. In addit...

journal_title：Immunity

authors： Luther SA,Lopez T,Bai W,Hanahan D,Cyster JG

更新日期：2000-05-01 00:00:00

abstract：:The central nervous system undergoes extensive postnatal synapse remodeling that is critical for the formation of mature neural circuits. In a recent issue of Science, Vainchtein et al. (2018) describe an additional role for astrocyte-derived interleukin-33 (IL-33) in promoting synapse refinement by microglia in the d...

journal_title：Immunity

authors： Delmas C,Dalmas E

更新日期：2018-03-20 00:00:00

abstract：:mel-18 is a mammalian Polycomb group gene encoding a transcriptional repressor with tumor suppressive activity. Overexpression of mel-18 in mice results in cell cycle arrest of B cells upon B cell receptor stimulation with downregulation of c-myc. This phenotype is rescued in mel-18/c-myc double-transgenic mice, sugge...

journal_title：Immunity

authors： Tetsu O,Ishihara H,Kanno R,Kamiyasu M,Inoue H,Tokuhisa T,Taniguchi M,Kanno M

更新日期：1998-10-01 00:00:00

abstract：:The cause of common polygenic autoimmune diseases is not understood because of genetic and cellular complexity. Here, we pinpoint the action of a subset of autoimmune susceptibility loci in the NOD mouse strain linked to D1mit181, D2mit490, D7mit101, and D15mit229, which cause a generalized resistance to thymic deleti...

journal_title：Immunity

authors： Liston A,Lesage S,Gray DH,O'Reilly LA,Strasser A,Fahrer AM,Boyd RL,Wilson J,Baxter AG,Gallo EM,Crabtree GR,Peng K,Wilson SR,Goodnow CC

更新日期：2004-12-01 00:00:00

abstract：:Neonatal female mice injected with the self ZP3 peptide are not tolerant to the peptide; they develop autoimmune ovarian disease (AOD) and autoantibody response 5 weeks later. ZP3 challenge leads to severe AOD and ZP3-specific T cell and antibody responses. In contrast, neonatal tolerance to foreign ZP3 peptide is est...

journal_title：Immunity

authors： Garza KM,Griggs ND,Tung KS

更新日期：1997-01-01 00:00:00

abstract：:NLRP3 nucleates the inflammasome, a protein complex responsible for cleavage of prointerleukin-1beta (IL-1beta) to its active form. Mutations in the NLRP3 gene cause the autoinflammatory disease spectrum cryopyrin-associated periodic syndromes (CAPS). The central role of IL-1beta in CAPS is supported by the response t...

journal_title：Immunity

authors： Brydges SD,Mueller JL,McGeough MD,Pena CA,Misaghi A,Gandhi C,Putnam CD,Boyle DL,Firestein GS,Horner AA,Soroosh P,Watford WT,O'Shea JJ,Kastner DL,Hoffman HM

更新日期：2009-06-19 00:00:00

abstract：:Two recent Immunity papers link peripheral tolerance with the ability of developing B cells to capture BAFF. These findings suggest that an increase in effective BAFF levels leads to autoreactive B cell maturation. ...

journal_title：Immunity

authors： Cancro MP

更新日期：2004-06-01 00:00:00

abstract：:Interleukin 9 (IL-9) is a pleiotropic cytokine that can regulate autoimmune responses by enhancing regulatory CD4(+)FoxP3(+) T regulatory (Treg) cell survival and T helper 17 (Th17) cell proliferation. Here, we analyzed the costimulatory requirements for the induction of Th9 cells, and demonstrated that Notch pathway ...

journal_title：Immunity

authors： Elyaman W,Bassil R,Bradshaw EM,Orent W,Lahoud Y,Zhu B,Radtke F,Yagita H,Khoury SJ

更新日期：2012-04-20 00:00:00