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BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis.

Abstract：

:CXCR5, the receptor for B lymphocyte chemoattractant (BLC), is required for normal development of Peyer's patches, inguinal lymph nodes, and splenic follicles. To test the in vivo activity of BLC in isolation of other lymphoid organizers, transgenic mice were generated expressing BLC in the pancreatic islets. In addition to attracting B cells, BLC expression led to development of lymph node-like structures that contained B and T cell zones, high endothelial venules, stromal cells, and the chemokine SLC. Development of these features was strongly dependent on B lymphocytes and on lymphotoxin alpha1beta2 and could be reversed by blocking lymphotoxin alpha1beta2. These findings establish that BLC is sufficient to activate a pathway of events leading to formation of organized lymphoid tissue.

journal_name

Immunity

journal_title

Immunity

authors

Luther SA,Lopez T,Bai W,Hanahan D,Cyster JG

doi

10.1016/s1074-7613(00)80199-5

keywords:

subject

Has Abstract

pub_date

2000-05-01 00:00:00

pages

471-81

issue

5

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(00)80199-5

journal_volume

12

pub_type

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