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Preexisting high frequencies of memory CD8+ T cells favor rapid memory differentiation and preservation of proliferative potential upon boosting.

Abstract：

:Memory CD8+ T cell quantity and quality determine protective efficacy against reinfection. Heterologous prime boost vaccination minimizes contraction of anamnestic effectors and maximizes memory CD8+ T cell quantity but reportedly erodes proliferative potential and protective efficacy. This study exploited heterologous prime boost vaccination to discover parameters regulating effector CD8+ T cell contraction and memory differentiation. When abundant memory T cells were established, boosting induced only 5-8 cell divisions, unusually rapid memory T cell differentiation as measured by phenotype and mitochondrial bioenergetic function, long-lived survival of 50% of effector T cells, and preservation of proliferative potential. Conversely, boosting in situations of low memory CD8+ T cell frequencies induced many cell divisions, increased contraction of effector cells, and caused senescence, low mitochondrial membrane potential, and poorly protective memory. Thus, anamnestic memory T cell differentiation is flexible, and abundant quantity can be achieved while maximizing protective efficacy and preserving proliferative potential.

journal_name

Immunity

journal_title

Immunity

authors

Fraser KA,Schenkel JM,Jameson SC,Vezys V,Masopust D

doi

10.1016/j.immuni.2013.07.003

subject

Has Abstract

pub_date

2013-07-25 00:00:00

pages

171-83

issue

1

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(13)00287-2

journal_volume

39

pub_type

杂志文章

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