当前位置： SCI文献检索 > IMMUNITY期刊下所有文献 > Central tolerance matters.

Central tolerance matters.

Abstract：

:In this issue of Immunity, Anderson et al. provide another clue to the riddle that is Aire--why do human beings and mice lacking Aire develop diffuse and pathogenic autoimmunity? They find that Aire influences central tolerance not only by promoting the expression of peripheral self-proteins in thymic medullary epithelial cells (MECs) but also by furnishing these cells with the apparatus for effective antigen presentation ().

journal_name

Immunity

journal_title

Immunity

authors

Goldrath AW,Hedrick SM

doi

10.1016/j.immuni.2005.08.004

keywords:

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

113-4

issue

2

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(05)00242-6

journal_volume

23

pub_type

评论,杂志文章,评审

相关文献

IMMUNITY文献大全
  • Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.

    abstract：:NLRP3 nucleates the inflammasome, a protein complex responsible for cleavage of prointerleukin-1beta (IL-1beta) to its active form. Mutations in the NLRP3 gene cause the autoinflammatory disease spectrum cryopyrin-associated periodic syndromes (CAPS). The central role of IL-1beta in CAPS is supported by the response t...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2009.05.005

    authors： Brydges SD,Mueller JL,McGeough MD,Pena CA,Misaghi A,Gandhi C,Putnam CD,Boyle DL,Firestein GS,Horner AA,Soroosh P,Watford WT,O'Shea JJ,Kastner DL,Hoffman HM

    更新日期：2009-06-19 00:00:00

  • Vaccine adjuvants: putting innate immunity to work.

    abstract：:Adjuvants enhance immunity to vaccines and experimental antigens by a variety of mechanisms. In the past decade, many receptors and signaling pathways in the innate immune system have been defined and these innate responses strongly influence the adaptive immune response. The focus of this review is to delineate the i...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2010.10.002

    authors： Coffman RL,Sher A,Seder RA

    更新日期：2010-10-29 00:00:00

  • Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2.

    abstract：:Myeloid-derived suppressor cells (MDSCs) and cancer stem cells (CSCs) are important cellular components in the cancer microenvironment and may affect cancer phenotype and patient outcome. The nature of MDSCs and their interaction with CSCs in ovarian carcinoma are unclear. We examined the interaction between MDSCs and...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2013.08.025

    authors： Cui TX,Kryczek I,Zhao L,Zhao E,Kuick R,Roh MH,Vatan L,Szeliga W,Mao Y,Thomas DG,Kotarski J,Tarkowski R,Wicha M,Cho K,Giordano T,Liu R,Zou W

    更新日期：2013-09-19 00:00:00

  • Positional cloning and molecular characterization of an immunodominant cytotoxic determinant of the mouse H3 minor histocompatibility complex.

    abstract：:Immune responses to minor histocompatibility antigens are poorly understood and present substantial barriers to successful solid tissue and bone marrow transplantation among MHC-matched individuals. We exploited a unique positional cloning approach relying on the potent negative selection capability of cytotoxic T cel...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80666-4

    authors： Zuberi AR,Christianson GJ,Mendoza LM,Shastri N,Roopenian DC

    更新日期：1998-11-01 00:00:00

  • A High-Dimensional Atlas of Human T Cell Diversity Reveals Tissue-Specific Trafficking and Cytokine Signatures.

    abstract：:Depending on the tissue microenvironment, T cells can differentiate into highly diverse subsets expressing unique trafficking receptors and cytokines. Studies of human lymphocytes have primarily focused on a limited number of parameters in blood, representing an incomplete view of the human immune system. Here, we hav...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.07.007

    authors： Wong MT,Ong DE,Lim FS,Teng KW,McGovern N,Narayanan S,Ho WQ,Cerny D,Tan HK,Anicete R,Tan BK,Lim TK,Chan CY,Cheow PC,Lee SY,Takano A,Tan EH,Tam JK,Tan EY,Chan JK,Fink K,Bertoletti A,Ginhoux F,Curotto de Lafail

    更新日期：2016-08-16 00:00:00

  • Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death.

    abstract：:La Crosse virus (LACV), a zoonotic Bunyavirus, is a major cause of pediatric viral encephalitis in the United States. A hallmark of neurological diseases caused by LACV and other encephalitic viruses is the induction of neuronal cell death. Innate immune responses have been implicated in neuronal damage, but no mechan...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2013.02.013

    authors： Mukherjee P,Woods TA,Moore RA,Peterson KE

    更新日期：2013-04-18 00:00:00

  • The E3 ubiquitin ligase Pellino3 protects against obesity-induced inflammation and insulin resistance.

    abstract：:Diet-induced obesity can induce low-level inflammation and insulin resistance. Interleukin-1β (IL-1β) is one of the key proinflammatory cytokines that contributes to the generation of insulin resistance and diabetes, but the mechanisms that regulate obesity-driven inflammation are ill defined. Here we found reduced ex...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2014.11.013

    authors： Yang S,Wang B,Humphries F,Hogan AE,O'Shea D,Moynagh PN

    更新日期：2014-12-18 00:00:00

  • Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway.

    abstract：:Although infections with virulent pathogens often induce a strong inflammatory reaction, what drives the increased immune response to pathogens compared to nonpathogenic microbes is poorly understood. One possibility is that the immune system senses the level of threat from a microorganism and augments the response ac...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2011.08.015

    authors： Boyer L,Magoc L,Dejardin S,Cappillino M,Paquette N,Hinault C,Charriere GM,Ip WK,Fracchia S,Hennessy E,Erturk-Hasdemir D,Reichhart JM,Silverman N,Lacy-Hulbert A,Stuart LM

    更新日期：2011-10-28 00:00:00

  • Fcgamma receptors: old friends and new family members.

    abstract：:Although cellular receptors for immunoglobulins were first identified nearly 40 years ago, their central role in the immune response was discovered only in the last decade. They are key players in both the afferent and efferent phase of an immune response, setting thresholds for B cell activation, regulating the matur...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2005.11.010

    authors： Nimmerjahn F,Ravetch JV

    更新日期：2006-01-01 00:00:00

  • Loss of CD47 Makes Dendritic Cells See Red.

    abstract：:Whereas dendritic cells (DCs) can be activated in many ways to trigger immunity, hardly anything is known about the mechanisms that counterbalance DC activation. Cyster and colleagues now demonstrate that the "self" molecule CD47 on erythrocytes critically restricts splenic DC activation. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2015.09.008

    authors： van den Berg TK,van Bruggen R

    更新日期：2015-10-20 00:00:00

  • T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response.

    abstract：:Dendritic cell (DC) activation is essential for the induction of immune defense against pathogens, yet needs to be tightly controlled to avoid chronic inflammation and exaggerated immune responses. Here, we identify a mechanism of immune homeostasis by which adaptive immunity, once triggered, tempers DC activation and...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2013.06.010

    authors： Carrera Silva EA,Chan PY,Joannas L,Errasti AE,Gagliani N,Bosurgi L,Jabbour M,Perry A,Smith-Chakmakova F,Mucida D,Cheroutre H,Burstyn-Cohen T,Leighton JA,Lemke G,Ghosh S,Rothlin CV

    更新日期：2013-07-25 00:00:00

  • Blood monocytes consist of two principal subsets with distinct migratory properties.

    abstract：:Peripheral blood monocytes are a heterogeneous population of circulating leukocytes. Using a murine adoptive transfer system to probe monocyte homing and differentiation in vivo, we identified two functional subsets among murine blood monocytes: a short-lived CX(3)CR1(lo)CCR2(+)Gr1(+) subset that is actively recruited...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(03)00174-2

    authors： Geissmann F,Jung S,Littman DR

    更新日期：2003-07-01 00:00:00

  • The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin.

    abstract：:The mechanisms underpinning integration of instructions that program naive CD8+ T cells for effector and/or memory differentiation are not well understood. Herein, we demonstrate that interleukin-12 (IL-12) enhanced and sustained antigen and costimulatory molecule (B7.1)-induced mTOR kinase activity in naive CD8+ (OT-...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2009.10.010

    authors： Rao RR,Li Q,Odunsi K,Shrikant PA

    更新日期：2010-01-29 00:00:00

  • Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals.

    abstract：:The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune responses, especially adaptive immune responses to SARS-CoV-2 infection. Here, we collected blood from COVID-19 patients who have recently become virus-free, and therefo...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2020.04.023

    authors： Ni L,Ye F,Cheng ML,Feng Y,Deng YQ,Zhao H,Wei P,Ge J,Gou M,Li X,Sun L,Cao T,Wang P,Zhou C,Zhang R,Liang P,Guo H,Wang X,Qin CF,Chen F,Dong C

    更新日期：2020-06-16 00:00:00

  • Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement.

    abstract：:T lymphocyte receptor CTLA-4 binds costimulatory molecules CD80 (B7-1) and CD86 (B7-2) with high avidity and negatively regulates T cell activation. CTLA-4 functions at the cell surface, yet is primarily localized in intracellular vesicles. Here, we demonstrate cycling of CTLA-4 between intracellular stores and the ce...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80480-x

    authors： Linsley PS,Bradshaw J,Greene J,Peach R,Bennett KL,Mittler RS

    更新日期：1996-06-01 00:00:00

  • Mass Cytometry of the Human Mucosal Immune System Identifies Tissue- and Disease-Associated Immune Subsets.

    abstract：:Inflammatory intestinal diseases are characterized by abnormal immune responses and affect distinct locations of the gastrointestinal tract. Although the role of several immune subsets in driving intestinal pathology has been studied, a system-wide approach that simultaneously interrogates all major lineages on a sing...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.04.014

    authors： van Unen V,Li N,Molendijk I,Temurhan M,Höllt T,van der Meulen-de Jong AE,Verspaget HW,Mearin ML,Mulder CJ,van Bergen J,Lelieveldt BP,Koning F

    更新日期：2016-05-17 00:00:00

  • Prostaglandin E2 suppresses antifungal immunity by inhibiting interferon regulatory factor 4 function and interleukin-17 expression in T cells.

    abstract：:T helper 17 (Th17) cells play an important role in mucosal host defense through production of the signature cytokines IL-17 and IL-22. Prostaglandin E2 (PGE2) has been shown to enhance IL-17 production by mature Th17 cells. However, when present during Th17 cell differentiation, we found that PGE2 inhibited the transc...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2012.02.013

    authors： Valdez PA,Vithayathil PJ,Janelsins BM,Shaffer AL,Williamson PR,Datta SK

    更新日期：2012-04-20 00:00:00

  • Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection.

    abstract：:Interleukin-1 (IL-1) receptor signaling is necessary for control of Mycobacterium tuberculosis (Mtb) infection, yet the role of its two ligands, IL-1α and IL-1β, and their regulation in vivo are poorly understood. Here, we showed that both IL-1α and IL-1β are critically required for host resistance and identified two ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2011.12.002

    authors： Mayer-Barber KD,Andrade BB,Barber DL,Hieny S,Feng CG,Caspar P,Oland S,Gordon S,Sher A

    更新日期：2011-12-23 00:00:00

  • Functional characterization of a novel hematopoietic stem cell and its place in the c-Kit maturation pathway in bone marrow cell development.

    abstract：:While the majority of purified pluripotential hematopoietic stem cells (PHSC) express c-Kit, the receptor for steel factor, we have phenotypically and functionally separated a distinct class of PHSC that does not express c-Kit. In contrast to c-Kit-positive (c-Kit(pos)) PHSC, the c-Kit-negative (c-Kit(neg)) PHSC do no...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80018-7

    authors： Ortiz M,Wine JW,Lohrey N,Ruscetti FW,Spence SE,Keller JR

    更新日期：1999-02-01 00:00:00

  • Natural killer cells activated by MHC class I(low) targets prime dendritic cells to induce protective CD8 T cell responses.

    abstract：:Conserved molecular patterns derived from pathogenic microorganisms prime antigen-presenting dendritic cells (DC) to induce adaptive T cell responses. In contrast, virus-infected or tumor cells that express low levels of major histocompatibility complex (MHC) class I activate natural killer (NK) cells for direct killi...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(03)00264-4

    authors： Mocikat R,Braumüller H,Gumy A,Egeter O,Ziegler H,Reusch U,Bubeck A,Louis J,Mailhammer R,Riethmüller G,Koszinowski U,Röcken M

    更新日期：2003-10-01 00:00:00

  • Regulatory T cell lineage specification by the forkhead transcription factor foxp3.

    abstract：:Regulatory T cell-mediated dominant tolerance has been demonstrated to play an important role in the prevention of autoimmunity. Here, we present data arguing that the forkhead transcription factor Foxp3 acts as the regulatory T cell lineage specification factor and mediator of the genetic mechanism of dominant tolera...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2005.01.016

    authors： Fontenot JD,Rasmussen JP,Williams LM,Dooley JL,Farr AG,Rudensky AY

    更新日期：2005-03-01 00:00:00

  • Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease.

    abstract：:Mice carrying a hypomorphic point mutation in the Ptpn6 gene (Ptpn6spin mice) develop an inflammatory skin disease that resembles neutrophilic dermatosis in humans. Here, we demonstrated that interleukin-1α (IL-1α) signaling through IL-1R and MyD88 in both stromal and immune cells drive inflammation in Ptpn6spin mice....

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2017.03.014

    authors： Gurung P,Fan G,Lukens JR,Vogel P,Tonks NK,Kanneganti TD

    更新日期：2017-04-18 00:00:00

  • IFN-γ signals a changing of the guards.

    abstract：:After acute inflammation or infection, tissue-resident macrophages are replaced by inflammatory DCs and effector macrophages that arise from circulating monocytes. In this issue of Immunity, Goldszmid et al. (2012) demonstrate a central role for NK cell-derived IFN-γ in signaling and facilitating this transition. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2012.06.007

    authors： Yap GS,Rivera A

    更新日期：2012-06-29 00:00:00

  • Distinct Surface Expression of Activating Receptor Ly49H Drives Differential Expansion of NK Cell Clones upon Murine Cytomegalovirus Infection.

    abstract：:Natural killer (NK) cells show some features of adaptive immunity but have not been studied at the clonal level. Here, we used retrogenic color-barcoding and single-cell adoptive transfers to track clonal immune responses to murine cytomegalovirus (MCMV) infection, derived from individual NK cells expressing activatin...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2019.04.015

    authors： Grassmann S,Pachmayr LO,Leube J,Mihatsch L,Andrae I,Flommersfeld S,Oduro J,Cicin-Sain L,Schiemann M,Flossdorf M,Buchholz VR

    更新日期：2019-06-18 00:00:00

  • Epstein-Barr virus coopts lipid rafts to block the signaling and antigen transport functions of the BCR.

    abstract：:The B cell antigen receptor (BCR) functions to initiate signaling and to internalize antigen for processing from within Lyn kinase-enriched membrane lipid rafts. The signaling function of the BCR is blocked by Epstein-Barr Virus (EBV) latent membrane protein 2A (LMP2A), which is constitutively phosphorylated by Lyn. H...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(01)00089-9

    authors： Dykstra ML,Longnecker R,Pierce SK

    更新日期：2001-01-01 00:00:00

  • TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells.

    abstract：:To examine the role of the TNF-R superfamily signaling protein TRAF2 in mature B cell development and NF-kappaB activation, conditionally TRAF2-deficient mice were produced. B cells lacking TRAF2 expression in these mice possessed a selective survival advantage, accumulated in the lymph nodes and splenic marginal zone...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2004.09.011

    authors： Grech AP,Amesbury M,Chan T,Gardam S,Basten A,Brink R

    更新日期：2004-11-01 00:00:00

  • Follicular Dendritic Cell Activation by TLR Ligands Promotes Autoreactive B Cell Responses.

    abstract：:A hallmark of autoimmunity in murine models of lupus is the formation of germinal centers (GCs) in lymphoid tissues where self-reactive B cells expand and differentiate. In the host response to foreign antigens, follicular dendritic cells (FDCs) maintain GCs through the uptake and cycling of complement-opsonized immun...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.12.014

    authors： Das A,Heesters BA,Bialas A,O'Flynn J,Rifkin IR,Ochando J,Mittereder N,Carlesso G,Herbst R,Carroll MC

    更新日期：2017-01-17 00:00:00

  • Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization.

    abstract：:Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor mediating innate antimicrobial immunity. It catalyzes the synthesis of a noncanonical cyclic dinucleotide, 2',5' cGAMP, that binds to STING and mediates the activation of TBK1 and IRF-3. Activated IRF-3 translocates to the nucleus and initiates the transcription...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2013.10.019

    authors： Li X,Shu C,Yi G,Chaton CT,Shelton CL,Diao J,Zuo X,Kao CC,Herr AB,Li P

    更新日期：2013-12-12 00:00:00

  • Baseless assumptions: activation of TLR9 by DNA.

    abstract：:The Toll-like receptor 9 (TLR9) is activated by DNA presented in acidified, intracellular compartments. Previous studies suggested that signaling required unmethylated CpG dinucleotides, but in this issue of Immunity, Haas et al. (2008) challenge this view, showing that DNA can activate TLR9 in a sequence-independent ...

    journal_title：Immunity

    pub_type： 评论,杂志文章,评审

    doi：10.1016/j.immuni.2008.02.009

    authors： Gangloff M,Gay NJ

    更新日期：2008-03-01 00:00:00

  • IL-22 gets to the stem of colorectal cancer.

    abstract：:Cytokines can provide survival and proliferation signals to cancer cells, thus promoting tumor progression. In this issue of Immunity, Kryczek et al. (2014) reveal that interleukin-22 can also promote "stemness" in human colorectal cancer via transcription factor STAT3-mediated epigenetic regulation of stem cell genes...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2014.04.014

    authors： Koltsova EK,Grivennikov SI

    更新日期：2014-05-15 00:00:00