当前位置： SCI文献检索 > IMMUNITY期刊下所有文献 > Somatic hypermutation in the heavy chain locus correlates with transcription.

Somatic hypermutation in the heavy chain locus correlates with transcription.

Abstract：

:Three mutant immunoglobulin heavy chain (IgH) insertion mice were generated in which a targeted nonfunctional IgH passenger transgene was either devoid of promoter (pdelta) or was placed under the transcriptional control of either its own RNA polymerase II-dependent IgH promoter (pII) or a RNA polymerase I-dependent promoter (pI). While the transgene mutation-frequency (0.85%) in memory B cells of pI mice was reduced compared to that in pII mice (1.4%), the distribution and the base exchange pattern of point mutations were comparable. In pdelta mice, the mutation frequency was drastically reduced (0.09%). The mutation frequencies correlated with the levels of transgene-specific pre-mRNA expressed in germinal center B cells isolated from the mutant mice.

journal_name

Immunity

journal_title

Immunity

authors

Fukita Y,Jacobs H,Rajewsky K

doi

10.1016/s1074-7613(00)80592-0

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

105-14

issue

1

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(00)80592-0

journal_volume

9

pub_type

杂志文章

相关文献

IMMUNITY文献大全
  • Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome.

    abstract：:Regulatory T (Treg) cells are essential for maintaining immune homeostasis. Although Foxp3 expression marks the commitment of progenitors to Treg cell lineage, how Treg cells are generated during lymphocyte development remains enigmatic. We report here that the c-Rel transcription factor controlled development of Treg...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2009.10.006

    authors： Ruan Q,Kameswaran V,Tone Y,Li L,Liou HC,Greene MI,Tone M,Chen YH

    更新日期：2009-12-18 00:00:00

  • Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response.

    abstract：:Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retent...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(02)00281-9

    authors： Brakebusch C,Fillatreau S,Potocnik AJ,Bungartz G,Wilhelm P,Svensson M,Kearney P,Körner H,Gray D,Fässler R

    更新日期：2002-03-01 00:00:00

  • Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen.

    abstract：:Superantigens (SAgs) are proteins produced by pathogenic microbes to elicit potent, antigen-independent T cell responses that are believed to enhance the microbes' pathogenicity. Here we show that the human lymphotropic herpesvirus Epstein-Barr virus (EBV) transcriptionally activates the env gene of an endogenous retr...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(01)00210-2

    authors： Sutkowski N,Conrad B,Thorley-Lawson DA,Huber BT

    更新日期：2001-10-01 00:00:00

  • A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses.

    abstract：:Recruitment of immune cells with antimicrobial activities is essential to fight local infections but has the potential to trigger immunopathology. Whether the immune system has the ability to sense inflammation intensity and self-adjust accordingly to limit tissue damage remains to be fully established. During local i...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2018.07.014

    authors： Postat J,Olekhnovitch R,Lemaître F,Bousso P

    更新日期：2018-10-16 00:00:00

  • Production of the Cytokine VEGF-A by CD4+ T and Myeloid Cells Disrupts the Corneal Nerve Landscape and Promotes Herpes Stromal Keratitis.

    abstract：:Herpes simplex virus type 1 (HSV-1)-infected corneas can develop a blinding immunoinflammatory condition called herpes stromal keratitis (HSK), which involves the loss of corneal sensitivity due to retraction of sensory nerves and subsequent hyperinnervation with sympathetic nerves. Increased concentrations of the cyt...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2020.10.013

    authors： Yun H,Yee MB,Lathrop KL,Kinchington PR,Hendricks RL,St Leger AJ

    更新日期：2020-11-17 00:00:00

  • Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against malaria.

    abstract：:Antibodies play major roles in immunity to malaria; however, a limited understanding of mechanisms mediating protection is a major barrier to vaccine development. We have demonstrated that acquired human anti-malarial antibodies promote complement deposition on the merozoite to mediate inhibition of erythrocyte invasi...

    journal_title：Immunity

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.immuni.2015.02.012

    authors： Boyle MJ,Reiling L,Feng G,Langer C,Osier FH,Aspeling-Jones H,Cheng YS,Stubbs J,Tetteh KK,Conway DJ,McCarthy JS,Muller I,Marsh K,Anders RF,Beeson JG

    更新日期：2015-03-17 00:00:00

  • Retinoic acid imprints gut-homing specificity on T cells.

    abstract：:For a preferential homing of T cells to the gut, expression of the integrin alpha4beta7 and the chemokine receptor CCR9 is essential and is induced by antigenic stimulation with dendritic cells from the gut-associated lymphoid organs. Here, we show that the vitamin A (retinol) metabolite, retinoic acid, enhances the e...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2004.08.011

    authors： Iwata M,Hirakiyama A,Eshima Y,Kagechika H,Kato C,Song SY

    更新日期：2004-10-01 00:00:00

  • Extrathymically Generated Regulatory T Cells Establish a Niche for Intestinal Border-Dwelling Bacteria and Affect Physiologic Metabolite Balance.

    abstract：:The mammalian gut microbiota provides essential metabolites to the host and promotes the differentiation and accumulation of extrathymically generated regulatory T (pTreg) cells. To explore the impact of these cells on intestinal microbial communities, we assessed the composition of the microbiota in pTreg cell-defici...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2018.04.013

    authors： Campbell C,Dikiy S,Bhattarai SK,Chinen T,Matheis F,Calafiore M,Hoyos B,Hanash A,Mucida D,Bucci V,Rudensky AY

    更新日期：2018-06-19 00:00:00

  • Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R-STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity.

    abstract：:Interleukin-2 (IL-2) and downstream transcription factor STAT5 are important for maintaining regulatory T (Treg) cell homeostasis and function. Treg cells can respond to low IL-2 levels, but the mechanisms of STAT5 activation during partial IL-2 deficiency remain uncertain. We identified the serine-threonine kinase Ms...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2018.10.010

    authors： Shi H,Liu C,Tan H,Li Y,Nguyen TM,Dhungana Y,Guy C,Vogel P,Neale G,Rankin S,Feng Y,Peng J,Tao W,Chi H

    更新日期：2018-11-20 00:00:00

  • Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity.

    abstract：:T cell antigen-presenting cell (APC) interactions early during chronic viral infection are crucial for determining viral set point and disease outcome, but how and when different APC subtypes contribute to these outcomes is unclear. The TNF receptor superfamily (TNFRSF) member GITR is important for CD4+ T cell accumul...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2017.10.014

    authors： Chang YH,Wang KC,Chu KL,Clouthier DL,Tran AT,Torres Perez MS,Zhou AC,Abdul-Sater AA,Watts TH

    更新日期：2017-11-21 00:00:00

  • Interleukin 10-mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum.

    abstract：:The immunodominant CD4 T cell epitope region, Th2R, of the circumsporozoite protein of Plasmodium falciparum is highly polymorphic. Such variation might be utilized by the parasite to escape from or interfere with CD4 T cell effector functions. Here, we show that costimulation with naturally occurring altered peptide ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80064-3

    authors： Plebanski M,Flanagan KL,Lee EA,Reece WH,Hart K,Gelder C,Gillespie G,Pinder M,Hill AV

    更新日期：1999-06-01 00:00:00

  • A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis.

    abstract：:T cell receptor (TCR) transgenic mice specific for hen egg lysozyme (HEL) were crossed with mice expressing HEL on the thyroid epithelium, on pancreatic islet beta cells, or systemically. Depending on the pattern of HEL expression, deletion of double-positive thymocytes ranged from minimal to complete, and peripheral ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80528-2

    authors： Akkaraju S,Ho WY,Leong D,Canaan K,Davis MM,Goodnow CC

    更新日期：1997-08-01 00:00:00

  • Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease.

    abstract：:Expression of B cell-activating factor (BAFF), a critical B cell survival factor, is elevated in autoimmune and lymphoproliferative disorders. Mice overproducing BAFF develop systemic lupus erythematosus (SLE)-like disease and exhibit B cell activation of classical and alternative NF-kappaB-signaling pathways. We used...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2006.07.010

    authors： Enzler T,Bonizzi G,Silverman GJ,Otero DC,Widhopf GF,Anzelon-Mills A,Rickert RC,Karin M

    更新日期：2006-09-01 00:00:00

  • Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E.

    abstract：:Mast cells are tissue-resident immune cells that play a central role in allergic disease. These contributions are largely dependent on the acquisition of antigen-specific immunoglobulin E (IgE). Despite this requirement, studies of mast cell and IgE interactions have overlooked the mechanism by which mast cells acquir...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2012.09.022

    authors： Cheng LE,Hartmann K,Roers A,Krummel MF,Locksley RM

    更新日期：2013-01-24 00:00:00

  • Unique maturation program of the IgE response in vivo.

    abstract：:A key event in the pathogenesis of asthma and allergies is the production of IgE antibodies. We show here that IgE(+) cells were exceptional because they were largely found outside germinal centers and expressed, from very early on, a genetic program of plasma cells. In spite of their extragerminal center localization...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2006.12.006

    authors： Erazo A,Kutchukhidze N,Leung M,Christ AP,Urban JF Jr,Curotto de Lafaille MA,Lafaille JJ

    更新日期：2007-02-01 00:00:00

  • Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading.

    abstract：:Destruction of li by proteolysis is required for MHC class II molecules to bind antigenic peptides, and for transport of the resulting complexes to the cell surface. The cysteine protease cathepsin S is highly expressed in spleen, lymphocytes, monocytes, and other class II-positive cells, and is inducible with interfe...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80249-6

    authors： Riese RJ,Wolf PR,Brömme D,Natkin LR,Villadangos JA,Ploegh HL,Chapman HA

    更新日期：1996-04-01 00:00:00

  • Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4(+) T Cells.

    abstract：:Distinct metabolic programs support the differentiation of CD4(+) T cells into separate functional subsets. In this study, we investigated metabolic mechanisms underlying the differentiation of IL-9-producing CD4(+) T cells (Th9) in allergic airway inflammation and cancerous tumors. We found that histone deacetylase S...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.05.009

    authors： Wang Y,Bi Y,Chen X,Li C,Li Y,Zhang Z,Wang J,Lu Y,Yu Q,Su H,Yang H,Liu G

    更新日期：2016-06-21 00:00:00

  • Plague's partners in crime.

    abstract：:The hallmark of bubonic plague is the presence of grotesquely swollen lymph nodes, called buboes. This frenzied inflammatory response to Yersinia pestis is poorly understood. In this issue of Immunity, St. John et al. (2014) explore the mechanism by which Y. pestis spreads and thus leads to this striking lymphadenopat...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2014.09.003

    authors： Davis KM,Isberg RR

    更新日期：2014-09-18 00:00:00

  • Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing.

    abstract：:Efficient unidirectional killing by cytotoxic T lymphocytes (CTL) requires translocation of the microtubule organizing center (MTOC) to the target cell contact site. Here we utilize modulated polarization microscopy and computerized 3D reconstruction of tubulin and LFA-1 immunofluorescence images to investigate how th...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(02)00262-5

    authors： Kuhn JR,Poenie M

    更新日期：2002-01-01 00:00:00

  • NETched in Stone.

    abstract：:Gallstone formation in adults is a common, yet incompletely understood disease process. In this issue, Muñoz et al. (2019) report a pathogenic link between neutrophil extracellular traps (NETs) and the formation of gallstones. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2019.08.015

    authors： O'Neil LJ,Kaplan MJ

    更新日期：2019-09-17 00:00:00

  • The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans.

    abstract：:B cell subsets expressing the transcription factor T-bet are associated with humoral immune responses and autoimmunity. Here, we examined the anatomic distribution, clonal relationships, and functional properties of T-bet+ and T-bet- memory B cells (MBCs) in the context of the influenza-specific immune response. In mi...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2020.03.020

    authors： Johnson JL,Rosenthal RL,Knox JJ,Myles A,Naradikian MS,Madej J,Kostiv M,Rosenfeld AM,Meng W,Christensen SR,Hensley SE,Yewdell J,Canaday DH,Zhu J,McDermott AB,Dori Y,Itkin M,Wherry EJ,Pardi N,Weissman D,Naji A,Pra

    更新日期：2020-05-19 00:00:00

  • 2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity.

    abstract：:TRAIL is a newly identified cytokine belonging to the large tumor necrosis factor (TNF) family. TRAIL is a novel molecule inducing apoptosis in a wide variety of tumor cells but not in normal cells. To help in elucidating its biological roles and designing mutants with improved therapeutic potential, we have determine...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80100-4

    authors： Cha SS,Kim MS,Choi YH,Sung BJ,Shin NK,Shin HC,Sung YC,Oh BH

    更新日期：1999-08-01 00:00:00

  • Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia.

    abstract：:The ETS gene Fli-1 is involved in the induction of erythroleukemia in mice by Friend murine leukemia virus and Ewings sarcoma in children. Mice with a targeted null mutation in the Fli-1 locus die at day 11.5 of embryogenesis with loss of vascular integrity leading to bleeding within the vascular plexus of the cerebra...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)00017-0

    authors： Hart A,Melet F,Grossfeld P,Chien K,Jones C,Tunnacliffe A,Favier R,Bernstein A

    更新日期：2000-08-01 00:00:00

  • Regulatory T cells and inflammation: better late than never.

    abstract：:In this issue of Immunity, Curotto de Lafaille et al. (2008) show that adaptive T regulatory cells control airway inflammation and that it is when they are generated that determines whether they function during acute or chronic inflammation. ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2008.07.001

    authors： Ziegler SF

    更新日期：2008-07-18 00:00:00

  • PGRP-SD, an Extracellular Pattern-Recognition Receptor, Enhances Peptidoglycan-Mediated Activation of the Drosophila Imd Pathway.

    abstract：:Activation of the innate immune response in Metazoans is initiated through the recognition of microbes by host pattern-recognition receptors. In Drosophila, diaminopimelic acid (DAP)-containing peptidoglycan from Gram-negative bacteria is detected by the transmembrane receptor PGRP-LC and by the intracellular receptor...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.10.029

    authors： Iatsenko I,Kondo S,Mengin-Lecreulx D,Lemaitre B

    更新日期：2016-11-15 00:00:00

  • Analysis of a SARS-CoV-2-Infected Individual Reveals Development of Potent Neutralizing Antibodies with Limited Somatic Mutation.

    abstract：:Antibody responses develop following SARS-CoV-2 infection, but little is known about their epitope specificities, clonality, binding affinities, epitopes, and neutralizing activity. We isolated B cells specific for the SARS-CoV-2 envelope glycoprotein spike (S) from a COVID-19-infected subject 21 days after the onset ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2020.06.001

    authors： Seydoux E,Homad LJ,MacCamy AJ,Parks KR,Hurlburt NK,Jennewein MF,Akins NR,Stuart AB,Wan YH,Feng J,Whaley RE,Singh S,Boeckh M,Cohen KW,McElrath MJ,Englund JA,Chu HY,Pancera M,McGuire AT,Stamatatos L

    更新日期：2020-07-14 00:00:00

  • Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection.

    abstract：:Mycobacterium tuberculosis infection in humans triggers formation of granulomas, which are tightly organized immune cell aggregates that are the central structure of tuberculosis. Infected and uninfected macrophages interdigitate, assuming an altered, flattened appearance. Although pathologists have described these ch...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.09.014

    authors： Cronan MR,Beerman RW,Rosenberg AF,Saelens JW,Johnson MG,Oehlers SH,Sisk DM,Jurcic Smith KL,Medvitz NA,Miller SE,Trinh LA,Fraser SE,Madden JF,Turner J,Stout JE,Lee S,Tobin DM

    更新日期：2016-10-18 00:00:00

  • Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2.

    abstract：:Myeloid-derived suppressor cells (MDSCs) and cancer stem cells (CSCs) are important cellular components in the cancer microenvironment and may affect cancer phenotype and patient outcome. The nature of MDSCs and their interaction with CSCs in ovarian carcinoma are unclear. We examined the interaction between MDSCs and...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2013.08.025

    authors： Cui TX,Kryczek I,Zhao L,Zhao E,Kuick R,Roh MH,Vatan L,Szeliga W,Mao Y,Thomas DG,Kotarski J,Tarkowski R,Wicha M,Cho K,Giordano T,Liu R,Zou W

    更新日期：2013-09-19 00:00:00

  • Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches.

    abstract：:In the bone marrow, the special microenvironment niches nurture a pool of hematopoietic stem cells (HSCs). Many HSCs reside near the vasculature, but the molecular regulatory mechanism of niches for HSC maintenance remains unclear. Here we showed that the induced deletion of CXCR4, a receptor for CXC chemokine ligand ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2006.10.016

    authors： Sugiyama T,Kohara H,Noda M,Nagasawa T

    更新日期：2006-12-01 00:00:00

  • Galactocerebrosides are required postnatally for stromal-dependent bone marrow lymphopoiesis.

    abstract：:Galactocerebrosides (GCs) represent a major class of glycolipids in the nervous system. Here, we show that mice lacking the key enzyme to generate GCs, UDP-galactose:ceramide galactosyltransferase (CGT(-/-)), exhibit severe postnatal atrophy of all lymphoid organs, owing to a maturational arrest before the pro-B/T cel...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(03)00150-x

    authors： Katayama Y,Frenette PS

    更新日期：2003-06-01 00:00:00