Abstract：
:Mast cells are tissue-resident immune cells that play a central role in allergic disease. These contributions are largely dependent on the acquisition of antigen-specific immunoglobulin E (IgE). Despite this requirement, studies of mast cell and IgE interactions have overlooked the mechanism by which mast cells acquire IgE from the blood. To address this gap, we developed reporter IgE molecules and employed imaging techniques to study mast cell function in situ. Our data demonstrate that skin mast cells exhibit selective uptake of IgE based on perivascular positioning. Furthermore, perivascular mast cells acquire IgE by extending cell processes across the vessel wall to capture luminal IgE. These data demonstrate how tissue mast cells acquire IgE and reveal a strategy by which extravascular cells monitor blood contents to capture molecules central to cellular function.
journal_name
Immunityjournal_title
Immunityauthors
Cheng LE,Hartmann K,Roers A,Krummel MF,Locksley RMdoi
10.1016/j.immuni.2012.09.022subject
Has Abstractpub_date
2013-01-24 00:00:00pages
166-75issue
1eissn
1074-7613issn
1097-4180pii
S1074-7613(12)00551-1journal_volume
38pub_type
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