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The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation.

Abstract：

:The death domain kinase RIP and the TNF receptor-associated factor 2 (TRAF2) are essential effectors in TNF signaling. To understand the mechanism by which RIP and TRAF2 regulate TNF-induced activation of the transcription factor NF-kappaB, we investigated their respective roles in TNF-R1-mediated IKK activation using both RIP-/- and TRAF2-/- fibroblasts. We found that TNF-R1-mediated IKK activation requires both RIP and TRAF2 proteins. Although TRAF2 or RIP can be independently recruited to the TNF-R1 complex, neither one of them alone is capable of transducing the TNF signal that leads to IKK activation. Moreover, we demonstrated that IKK is recruited to the TNF-R1 complex through TRAF2 upon TNF treatment and that IKK activation requires the presence of RIP in the same complex.

journal_name

Immunity

journal_title

Immunity

authors

Devin A,Cook A,Lin Y,Rodriguez Y,Kelliher M,Liu Z

doi

10.1016/s1074-7613(00)80194-6

keywords:

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

419-29

issue

4

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(00)80194-6

journal_volume

12

pub_type

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