当前位置： SCI文献检索 > IMMUNITY期刊下所有文献 > Vaccine adjuvants: putting innate immunity to work.

Vaccine adjuvants: putting innate immunity to work.

Abstract：

:Adjuvants enhance immunity to vaccines and experimental antigens by a variety of mechanisms. In the past decade, many receptors and signaling pathways in the innate immune system have been defined and these innate responses strongly influence the adaptive immune response. The focus of this review is to delineate the innate mechanisms by which adjuvants mediate their effects. We highlight how adjuvants can be used to influence the magnitude and alter the quality of the adaptive response in order to provide maximum protection against specific pathogens. Despite the impressive success of currently approved adjuvants for generating immunity to viral and bacterial infections, there remains a need for improved adjuvants that enhance protective antibody responses, especially in populations that respond poorly to current vaccines. However, the larger challenge is to develop vaccines that generate strong T cell immunity with purified or recombinant vaccine antigens.

journal_name

Immunity

journal_title

Immunity

authors

Coffman RL,Sher A,Seder RA

doi

10.1016/j.immuni.2010.10.002

subject

Has Abstract

pub_date

2010-10-29 00:00:00

pages

492-503

issue

4

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(10)00362-6

journal_volume

33

pub_type

杂志文章,评审

相关文献

IMMUNITY文献大全
  • Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo.

    abstract：:CD4 T cells are pivotal for effective immunity, yet their initial differentiation into effector subsets after infection remains poorly defined. We examined CD4 T cells specific for the immunodominant Leishmania major LACK antigen using MHC/peptide tetramers and IL-4 reporter mice. Comprising approximately 15 cells/lym...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(02)00363-1

    authors： Stetson DB,Mohrs M,Mallet-Designe V,Teyton L,Locksley RM

    更新日期：2002-08-01 00:00:00

  • CD8(+) T cell differentiation: choosing a path through T-bet.

    abstract：:Activated CD8(+) T cells can differentiate into transient effector cells or long-lived memory cells. In this issue of Immunity, Joshi et al. (2007) suggest that inflammatory cytokines dictate this balance by regulating the expression of the transcription factor T-bet. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2007.08.003

    authors： Hamilton SE,Jameson SC

    更新日期：2007-08-01 00:00:00

  • Distinct roles of L-selectin and integrins alpha 4 beta 7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ: the multistep model confirmed and refined.

    abstract：:Circulating lymphocytes home to the mucosal lymphoid organs, Peyer's patches (PP), through high endothelial venules (HEV). In situ analyses revealed that transfused lymph node cells (LNCs) interact with PP-HEV in a series of overlapping adhesion events: L-selectin (CD62L) > alpha 4 beta 7 initiates interaction, L-sele...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/1074-7613(95)90162-0

    authors： Bargatze RF,Jutila MA,Butcher EC

    更新日期：1995-07-01 00:00:00

  • Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4(+) T Cells.

    abstract：:Distinct metabolic programs support the differentiation of CD4(+) T cells into separate functional subsets. In this study, we investigated metabolic mechanisms underlying the differentiation of IL-9-producing CD4(+) T cells (Th9) in allergic airway inflammation and cancerous tumors. We found that histone deacetylase S...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.05.009

    authors： Wang Y,Bi Y,Chen X,Li C,Li Y,Zhang Z,Wang J,Lu Y,Yu Q,Su H,Yang H,Liu G

    更新日期：2016-06-21 00:00:00

  • Toll signaling in flies and mammals: two sorts of MyD88.

    abstract：:The mammalian MyD88 signaling molecule participates in Toll receptor signaling within the cytoplasm. In this issue of Immunity, Marek and Kagan (2012) report that Drosophila (d)MyD88 acts instead at the plasma membrane to sort the signaling adaptor Tube. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2012.04.001

    authors： Goto A,Imler JL

    更新日期：2012-04-20 00:00:00

  • Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65.

    abstract：:During signal transduction through the B cell antigen receptor (BCR), several signaling elements are brought together by the adaptor protein SLP-65. We have investigated the role of SLP-65 in B cell maturation and function in mice deficient for SLP-65. While the mice are viable, B cell development is affected at sever...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80130-2

    authors： Jumaa H,Wollscheid B,Mitterer M,Wienands J,Reth M,Nielsen PJ

    更新日期：1999-11-01 00:00:00

  • The crystal structure of H-2Dd MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4 A resolution: implications for T cell and NK cell recognition.

    abstract：:The structure of H-2Dd complexed with the HIV-derived peptide P18-I10 (RGPGRAFVTI) has been determined by X-ray crystallography at 2.4 A resolution. This MHC class I molecule has an unusual binding motif with four anchor residues in the peptide (G2, P3, R/K/H5, and I/L/F9 or 10). The cleft architecture of H-2Dd includ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80602-0

    authors： Achour A,Persson K,Harris RA,Sundbäck J,Sentman CL,Lindqvist Y,Schneider G,Kärre K

    更新日期：1998-08-01 00:00:00

  • αβ T cell receptors come out swinging.

    abstract：:It is unclear how an effective T cell repertoire is built from a limited array of T cell receptor (TCR) genes. In this issue of Immunity, Stadinski et al. (2011) demonstrate that TCR variable (V) α chains can indirectly affect Vβ-mediated recognition of the major histocompatibility complex (MHC) molecule. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2011.11.002

    authors： Turner SJ,Rossjohn J

    更新日期：2011-11-23 00:00:00

  • T cell costimulation via the integrin VLA-4 inhibits the actin-dependent centralization of signaling microclusters containing the adaptor SLP-76.

    abstract：:Antigen-dependent T cell activation drives the formation of signaling microclusters containing the adaptor SLP-76. Costimulatory integrins regulate SLP-76 phosphorylation and could influence SLP-76 microclusters in the integrin-rich periphery of the immune synapse. We report that costimulation by the integrin VLA-4 (a...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2008.04.019

    authors： Nguyen K,Sylvain NR,Bunnell SC

    更新日期：2008-06-01 00:00:00

  • The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells.

    abstract：:Type 2 innate lymphoid cells (ILC2s) are part of a large family of ILCs that are important effectors in innate immunity, lymphoid organogenesis, and tissue remodeling. ILC2s mediate parasite expulsion but also contribute to airway inflammation, emphasizing the functional similarity between these cells and Th2 cells. C...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2012.08.015

    authors： Mjösberg J,Bernink J,Golebski K,Karrich JJ,Peters CP,Blom B,te Velde AA,Fokkens WJ,van Drunen CM,Spits H

    更新日期：2012-10-19 00:00:00

  • Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function.

    abstract：:Epithelial cells orchestrate pulmonary homeostasis and pathogen defense and play a crucial role in the initiation of allergic immune responses. Maintaining the balance between homeostasis and inappropriate immune activation and associated pathology is particularly complex at mucosal sites that are exposed to billions ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2015.10.012

    authors： Denney L,Byrne AJ,Shea TJ,Buckley JS,Pease JE,Herledan GM,Walker SA,Gregory LG,Lloyd CM

    更新日期：2015-11-17 00:00:00

  • Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme.

    abstract：:Members of the extended interleukin-1 (IL-1) cytokine family, such as IL-1, IL-18, IL-33, and IL-36, play a pivotal role in the initiation and amplification of immune responses. However, deregulated production and/or activation of these cytokines can lead to the development of multiple inflammatory disorders. IL-1 fam...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2015.06.003

    authors： Afonina IS,Müller C,Martin SJ,Beyaert R

    更新日期：2015-06-16 00:00:00

  • Plasticity of T cell memory responses to viruses.

    abstract：:Virus-specific memory T cell populations demonstrate plasticity in antigenic and functional phenotype, in recognition of antigen, and in their ability to accommodate new memory T cell populations. The adaptability of complex antigen-specific T cell repertoires allows the host to respond to a diverse array of pathogens...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/s1074-7613(03)00356-x

    authors： Selin LK,Welsh RM

    更新日期：2004-01-01 00:00:00

  • PlexinD1 glycoprotein controls migration of positively selected thymocytes into the medulla.

    abstract：:Precise intrathymic cell migration is important for thymocyte maturation and organ architecture. The orchestration of thymocyte trafficking, however, is not well understood at a molecular level. Here, we described highly regulated plexinD1 expression on CD4+CD8+ double positive (DP) thymocytes. PlexinD1 expression was...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2008.10.008

    authors： Choi YI,Duke-Cohan JS,Ahmed WB,Handley MA,Mann F,Epstein JA,Clayton LK,Reinherz EL

    更新日期：2008-12-19 00:00:00

  • Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells.

    abstract：:Chimeric antigen receptors (CARs) redirect T cell cytotoxicity against cancer cells, providing a promising approach to cancer immunotherapy. Despite extensive clinical use, the attributes of CAR co-stimulatory domains that impact persistence and resistance to exhaustion of CAR-T cells remain largely undefined. Here, w...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.01.021

    authors： Kawalekar OU,O'Connor RS,Fraietta JA,Guo L,McGettigan SE,Posey AD Jr,Patel PR,Guedan S,Scholler J,Keith B,Snyder NW,Blair IA,Milone MC,June CH

    更新日期：2016-02-16 00:00:00

  • mel-18 negatively regulates cell cycle progression upon B cell antigen receptor stimulation through a cascade leading to c-myc/cdc25.

    abstract：:mel-18 is a mammalian Polycomb group gene encoding a transcriptional repressor with tumor suppressive activity. Overexpression of mel-18 in mice results in cell cycle arrest of B cells upon B cell receptor stimulation with downregulation of c-myc. This phenotype is rescued in mel-18/c-myc double-transgenic mice, sugge...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80627-5

    authors： Tetsu O,Ishihara H,Kanno R,Kamiyasu M,Inoue H,Tokuhisa T,Taniguchi M,Kanno M

    更新日期：1998-10-01 00:00:00

  • Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling.

    abstract：:Lentiviral Nef increases T cell signaling activity, but the molecular nature of the stimulus involved is incompletely described. We explored CD4 T cell lipid raft composition in the presence and absence of Nef. Here, the E2 ubiquitin-conjugating enzyme UbcH7, which acts in conjunction with c-Cbl, is absent from lipid ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2005.11.003

    authors： Simmons A,Gangadharan B,Hodges A,Sharrocks K,Prabhakar S,García A,Dwek R,Zitzmann N,McMichael A

    更新日期：2005-12-01 00:00:00

  • The COVID-19 Serology Studies Workshop: Recommendations and Challenges.

    abstract：:The development, validation, and appropriate application of serological assays to detect antibodies to SARS-CoV-2 are essential to determining seroprevalence of this virus in the United States and globally and in guiding government leadership and the private sector on back-to-work policies. An interagency working grou...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2020.06.012

    authors： Lerner AM,Eisinger RW,Lowy DR,Petersen LR,Humes R,Hepburn M,Cassetti MC

    更新日期：2020-07-14 00:00:00

  • Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo.

    abstract：:How antigen valency affects B cells in vivo during immune responses is not well understood. Here, using HIV immunogens with defined valencies ranging from 1 to 60, we investigated the role of antigen valency during different phases of B cell responses in vivo. Highly multimerized immunogens preferentially rapidly acti...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2020.08.001

    authors： Kato Y,Abbott RK,Freeman BL,Haupt S,Groschel B,Silva M,Menis S,Irvine DJ,Schief WR,Crotty S

    更新日期：2020-09-15 00:00:00

  • Infection, autoimmunity, and glycolipids: T cells detect microbes through self-recognition.

    abstract：:De Libero et al. (2005) demonstrate in this issue of Immunity that bacterial infection leads to increased synthesis of autologous glycolipids that are recognized by CD1-restricted human T cells, indicating that recognition of inducible self-glycolipids could be a mechanism for microbial detection. This mechanism also ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2005.06.001

    authors： Kronenberg M,Kinjo Y

    更新日期：2005-06-01 00:00:00

  • Monocyte-Derived Macrophages: The Missing Link in Organ Transplantation.

    abstract：:Successful organ transplantation requires an optimal innate immune response to avoid tissue injury. In this issue of Immunity, Braza et al. (2018) inhibit pro-inflammatory activation of infiltrating graft macrophages using nanotechnology tools to promote immune tolerance, leading to long-term transplant acceptance in ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2018.11.005

    authors： Pascual-Gil S,Epelman S

    更新日期：2018-11-20 00:00:00

  • Macrophage activation and polarization: nomenclature and experimental guidelines.

    abstract：:Description of macrophage activation is currently contentious and confusing. Like the biblical Tower of Babel, macrophage activation encompasses a panoply of descriptors used in different ways. The lack of consensus on how to define macrophage activation in experiments in vitro and in vivo impedes progress in multiple...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2014.06.008

    authors： Murray PJ,Allen JE,Biswas SK,Fisher EA,Gilroy DW,Goerdt S,Gordon S,Hamilton JA,Ivashkiv LB,Lawrence T,Locati M,Mantovani A,Martinez FO,Mege JL,Mosser DM,Natoli G,Saeij JP,Schultze JL,Shirey KA,Sica A,Suttles J,U

    更新日期：2014-07-17 00:00:00

  • A molecular basis for NKT cell recognition of CD1d-self-antigen.

    abstract：:The antigen receptor for natural killer T cells (NKT TCR) binds CD1d-restricted microbial and self-lipid antigens, although the molecular basis of self-CD1d recognition is unclear. Here, we have characterized NKT TCR recognition of CD1d molecules loaded with natural self-antigens (Ags) and report the 2.3 Å resolution ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2011.01.013

    authors： Mallevaey T,Clarke AJ,Scott-Browne JP,Young MH,Roisman LC,Pellicci DG,Patel O,Vivian JP,Matsuda JL,McCluskey J,Godfrey DI,Marrack P,Rossjohn J,Gapin L

    更新日期：2011-03-25 00:00:00

  • A Tumor Cell-Intrinsic Yin-Yang Determining Immune Evasion.

    abstract：:Pancreatic adenocarcinoma (PDAC) is mostly refractory to immunotherapies. In this issue of Immunity, Li et al. (2018) generate a library of clonal PDAC tumors to examine the tumor-intrinsic features shaping the anti-tumor immune response and find that tumor cell-derived CXCL1 directly blunts T cell infiltration and re...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2018.07.001

    authors： Horton B,Spranger S

    更新日期：2018-07-17 00:00:00

  • Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cells.

    abstract：:Memory lymphocytes are characterized by their ability to exhibit a rapid response to the recall antigen, in which differential transcription is important, yet the underlying mechanism is not understood. We report here a genome-wide analysis of histone methylation on two histone H3 lysine residues (H3K4me3 and H3K27me3...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2009.05.006

    authors： Araki Y,Wang Z,Zang C,Wood WH 3rd,Schones D,Cui K,Roh TY,Lhotsky B,Wersto RP,Peng W,Becker KG,Zhao K,Weng NP

    更新日期：2009-06-19 00:00:00

  • Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes.

    abstract：:For several days after antigenic stimulation, human cytolytic T lymphocyte (CTL) clones exhibit a decrease in their effector activity and in their binding to human leukocyte antigen (HLA)-peptide tetramers. We observed that, when in this state, CTLs lose the colocalization of the T cell receptor (TCR) and CD8. Effecto...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2008.01.011

    authors： Demotte N,Stroobant V,Courtoy PJ,Van Der Smissen P,Colau D,Luescher IF,Hivroz C,Nicaise J,Squifflet JL,Mourad M,Godelaine D,Boon T,van der Bruggen P

    更新日期：2008-03-01 00:00:00

  • Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation.

    abstract：:Particulate pollution is thought to function as an adjuvant that can induce allergic responses. However, the exact cell types and immunological factors that initiate the lung-specific immune responses are unclear. We found that upon intratracheal instillation, particulates such as aluminum salts and silica killed alve...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.11.010

    authors： Kuroda E,Ozasa K,Temizoz B,Ohata K,Koo CX,Kanuma T,Kusakabe T,Kobari S,Horie M,Morimoto Y,Nakajima S,Kabashima K,Ziegler SF,Iwakura Y,Ise W,Kurosaki T,Nagatake T,Kunisawa J,Takemura N,Uematsu S,Hayashi M,Aoshi T

    更新日期：2016-12-20 00:00:00

  • Multistage regulation of Th1-type immune responses by the transcription factor IRF-1.

    abstract：:Eradication of a given pathogen is dependent on the selective differentiation of T helper (Th) cells into Th1 or Th2 types. We show here that T cells from mice lacking the transcription factor IRF-1 fail to mount Th1 responses and instead exclusively undergo Th2 differentiation in vitro. Compromised Th1 differentiatio...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80443-4

    authors： Taki S,Sato T,Ogasawara K,Fukuda T,Sato M,Hida S,Suzuki G,Mitsuyama M,Shin EH,Kojima S,Taniguchi T,Asano Y

    更新日期：1997-06-01 00:00:00

  • CD40, but not CD40L, is required for the optimal priming of T cells and control of aerosol M. tuberculosis infection.

    abstract：:CD40(-/-) mice succumbed to low-dose aerosol infection with M. tuberculosis due to deficient IL-12 production leading to impaired priming of IFN-gamma T cell responses. In contrast, CD40L(-/-) mice were resistant to M. tuberculosis. This asymmetry in outcome of infection between the two knockout strains is likely due ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(03)00324-8

    authors： Lazarevic V,Myers AJ,Scanga CA,Flynn JL

    更新日期：2003-12-01 00:00:00

  • Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A.

    abstract：:Immunoglobulin A (IgA) is prominently secreted at mucosal surfaces and coats a fraction of the intestinal microbiota. However, the commensal bacteria bound by IgA are poorly characterized and the type of humoral immunity they elicit remains elusive. We used bacterial flow cytometry coupled with 16S rRNA gene sequencin...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2015.08.007

    authors： Bunker JJ,Flynn TM,Koval JC,Shaw DG,Meisel M,McDonald BD,Ishizuka IE,Dent AL,Wilson PC,Jabri B,Antonopoulos DA,Bendelac A

    更新日期：2015-09-15 00:00:00