Abstract：
:We analyzed the participation of a predominant B cell clonotype in the anti-arsonate immune response of mice in which Bcl-2 expression was enforced in B cells. Many of the antibodies expressed by the arsonate-induced memory compartment of these mice were "dual-reactive," displaying increased affinity acquired via V region somatic hypermutation for both arsonate and the autoantigen DNA. The hypermutated antibodies expressed by the anti-arsonate memory B cell compartment of normal mice have increased affinity for arsonate but lack measurable affinity for DNA. Thus, interference with apoptotic pathways allows developing memory B cells that have acquired autoreactivity to bypass a peripheral tolerance checkpoint. These data demonstrate that both positive and negative selection, working in concert with V gene somatic hypermutation, result in the "specificity maturation" of the antibody response.
journal_name
Immunityjournal_title
Immunityauthors
Hande S,Notidis E,Manser Tdoi
10.1016/s1074-7613(00)80471-9subject
Has Abstractpub_date
1998-02-01 00:00:00pages
189-98issue
2eissn
1074-7613issn
1097-4180pii
S1074-7613(00)80471-9journal_volume
8pub_type
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