Abstract：
:Epstein-Barr virus (EBV) establishes a persistent latent infection in peripheral B lymphocytes in humans and is associated with a variety of malignancies and proliferative disorders. Latent membrane protein 2A (LMP2A) is one of only two viral proteins expressed in latently infected B lymphocytes in vivo. LMP2A blocks B cell receptor (BCR) signal transduction in vitro by binding the Syk and Lyn protein tyrosine kinases. To analyze the significance of LMP2A expression in vivo, transgenic mice with B cell lineage expression of LMP2A were generated. LMP2A expression results in the bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs, indicating that LMP2A possesses a constitutive signaling activity in nontransformed cells.
journal_name
Immunityjournal_title
Immunityauthors
Caldwell RG,Wilson JB,Anderson SJ,Longnecker Rdoi
10.1016/s1074-7613(00)80623-8subject
Has Abstractpub_date
1998-09-01 00:00:00pages
405-11issue
3eissn
1074-7613issn
1097-4180pii
S1074-7613(00)80623-8journal_volume
9pub_type
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