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Nature's TRAIL--on a path to cancer immunotherapy.

Abstract：

:The TNF-related apoptosis-inducing ligand (TRAIL) offers great promise as a cancer therapeutic. Initially, soluble recombinant versions of the TRAIL molecule have exhibited specific tumoricidal activity against a variety of tumors alone, or in combination with other cancer treatments, and much anticipation awaits the outcomes from early clinical trials. More recently, the natural role of TRAIL has been explored in tumor and allogeneic bone marrow transplantation models in the mouse. Strikingly, the TRAIL effector pathway appears a vital component of immunosurveillance of spontaneous or resident tumor cells by both T cells and NK cells, stimulating more hope that manipulating TRAIL activity is a natural path to improved cancer immunotherapy.

journal_name

Immunity

journal_title

Immunity

authors

Smyth MJ,Takeda K,Hayakawa Y,Peschon JJ,van den Brink MR,Yagita H

doi

10.1016/s1074-7613(02)00502-2

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

1-6

issue

1

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(02)00502-2

journal_volume

18

pub_type

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