The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells.

abstract：:Following the fate of antigen-specific memory B cells has been difficult. In this issue of Immunity, Krishnamurty et al. (2016) use a novel B cell tetramer to define Plasmodium-specific memory B cells in parasite-infected mice and demonstrate that after re-infection, somatically mutated IgM(+) memory B cells function ...

journal_title：Immunity

authors： Stone SL,Lund FE

更新日期：2016-08-16 00:00:00

abstract：:Toll-like receptors (TLRs) sense pathogen-associated molecular patterns to activate the production of inflammatory mediators. TLR4 recognizes lipopolysaccharide (LPS) and drives the secretion of inflammatory cytokines, often contributing to sepsis. We report that transient receptor potential melastatin-like 7 (TRPM7),...

journal_title：Immunity

authors： Schappe MS,Szteyn K,Stremska ME,Mendu SK,Downs TK,Seegren PV,Mahoney MA,Dixit S,Krupa JK,Stipes EJ,Rogers JS,Adamson SE,Leitinger N,Desai BN

更新日期：2018-01-16 00:00:00

abstract：:Peptide-specific down-regulation of T cell responses may represent a powerful tool to intervene in autoimmune diseases or graft rejections. It is therefore important to know whether peptide treatment tolerizes both naive and antigen-experienced memory T lymphocytes. Here we show that a major histocompatibility complex...

journal_title：Immunity

authors： Aichele P,Brduscha-Riem K,Oehen S,Odermatt B,Zinkernagel RM,Hengartner H,Pircher H

更新日期：1997-05-01 00:00:00

abstract：:Activation of the transcription factor NF-kappa B and pre-T cell receptor (pre-TCR) expression is tightly correlated during thymocyte development. Inhibition of NF-kappa B in isolated thymocytes in vitro results in spontaneous apoptosis of cells expressing the pre-TCR, whereas inhibition of NF-kappa B in transgenic mi...

journal_title：Immunity

authors： Voll RE,Jimi E,Phillips RJ,Barber DF,Rincon M,Hayday AC,Flavell RA,Ghosh S

更新日期：2000-11-01 00:00:00

abstract：:Virus-specific memory T cell populations demonstrate plasticity in antigenic and functional phenotype, in recognition of antigen, and in their ability to accommodate new memory T cell populations. The adaptability of complex antigen-specific T cell repertoires allows the host to respond to a diverse array of pathogens...

journal_title：Immunity

authors： Selin LK,Welsh RM

更新日期：2004-01-01 00:00:00

abstract：:CD4 T cells are pivotal for effective immunity, yet their initial differentiation into effector subsets after infection remains poorly defined. We examined CD4 T cells specific for the immunodominant Leishmania major LACK antigen using MHC/peptide tetramers and IL-4 reporter mice. Comprising approximately 15 cells/lym...

journal_title：Immunity

authors： Stetson DB,Mohrs M,Mallet-Designe V,Teyton L,Locksley RM

更新日期：2002-08-01 00:00:00

abstract：:Reactive oxygen species (ROS) are generated during T cell activation and serve a signaling function but can also be damaging. In this issue of Immunity, Zhang et al. (2016) show that miR-23a prevents ROS-elicited necrosis by suppressing cyclophilin D (PPIF), a regulator of ROS escape from mitochondria. ...

journal_title：Immunity

authors： Agudo J,Brown BD

更新日期：2016-03-15 00:00:00

abstract：:Natural killer (NK) cells show some features of adaptive immunity but have not been studied at the clonal level. Here, we used retrogenic color-barcoding and single-cell adoptive transfers to track clonal immune responses to murine cytomegalovirus (MCMV) infection, derived from individual NK cells expressing activatin...

journal_title：Immunity

authors： Grassmann S,Pachmayr LO,Leube J,Mihatsch L,Andrae I,Flommersfeld S,Oduro J,Cicin-Sain L,Schiemann M,Flossdorf M,Buchholz VR

更新日期：2019-06-18 00:00:00

abstract：:In this issue of Immunity, Campbell et al. (2014) demonstrate that hypoxia caused by the respiratory burst of infiltrating neutrophils activates hypoxia inducible factor (HIF) in epithelial cells and protects the mucosa cells in an experimental model of inflammatory bowel disease. ...

journal_title：Immunity

authors： Borregaard N

更新日期：2014-01-16 00:00:00

abstract：:Acute hepatitis A (AHA) involves severe CD8+ T cell-mediated liver injury. Here we showed during AHA, CD8+ T cells specific to unrelated viruses became activated. Hepatitis A virus (HAV)-infected cells produced IL-15 that induced T cell receptor (TCR)-independent activation of memory CD8+ T cells. TCR-independent acti...

journal_title：Immunity

authors： Kim J,Chang DY,Lee HW,Lee H,Kim JH,Sung PS,Kim KH,Hong SH,Kang W,Lee J,Shin SY,Yu HT,You S,Choi YS,Oh I,Lee DH,Lee DH,Jung MK,Suh KS,Hwang S,Kim W,Park SH,Kim HJ,Shin EC

更新日期：2018-01-16 00:00:00

abstract：:Viruses have evolved elaborate mechanisms to target many aspects of the host's immune response. The cytokine IFN-gamma plays a central role in resistance of the host to infection via direct antiviral effects as well as modulation of the immune response. In this study, we demonstrate that the Epstein-Barr virus (EBV) i...

journal_title：Immunity

authors： Morrison TE,Mauser A,Wong A,Ting JP,Kenney SC

更新日期：2001-11-01 00:00:00

abstract：:Glycolysis is linked to the rapid response of memory CD8+ T cells, but the molecular and subcellular structural elements enabling enhanced glucose metabolism in nascent activated memory CD8+ T cells are unknown. We found that rapid activation of protein kinase B (PKB or AKT) by mammalian target of rapamycin complex 2 ...

journal_title：Immunity

authors： Bantug GR,Fischer M,Grählert J,Balmer ML,Unterstab G,Develioglu L,Steiner R,Zhang L,Costa ASH,Gubser PM,Burgener AV,Sauder U,Löliger J,Belle R,Dimeloe S,Lötscher J,Jauch A,Recher M,Hönger G,Hall MN,Romero P,Frez

更新日期：2018-03-20 00:00:00

abstract：:Fc gammaRIIB is an inhibitory receptor that terminates activation signals initiated by antigen cross-linking of the BCR through the recruitment of SHIP. Fc gammaRIIB can also signal independently of BCR coligation to directly mediate an apoptotic response, requiring only an intact transmembrane domain. Failure to recr...

journal_title：Immunity

authors： Pearse RN,Kawabe T,Bolland S,Guinamard R,Kurosaki T,Ravetch JV

更新日期：1999-06-01 00:00:00

abstract：:CD8 T cells persist at high frequencies in peripheral organs after resolution of an immune response, and their presence in the periphery is important for resistance to secondary challenge. We show here that LCMV-specific T cells in peripheral tissue (peritoneal cavity, lung, fat pads) reacted much less with the apopto...

journal_title：Immunity

authors： Wang XZ,Stepp SE,Brehm MA,Chen HD,Selin LK,Welsh RM

更新日期：2003-05-01 00:00:00

abstract：:The tolerogenic microenvironment of the liver is associated with impaired hepatic T cell function. Here, we examined the contribution of liver-resident natural killer (LrNK) cells, a prominent hepatic NK cell compartment, to T cell antiviral responses in the liver. The number of virus-specific T cells increased in LrN...

journal_title：Immunity

authors： Zhou J,Peng H,Li K,Qu K,Wang B,Wu Y,Ye L,Dong Z,Wei H,Sun R,Tian Z

更新日期：2019-02-19 00:00:00

abstract：:Activation-induced cytidine deaminase (AID) is required for immunoglobulin (Ig) gene class switch recombination (CSR), somatic hypermutation (SHM), and somatic hyperconversion. In general, high AID expression is found in mature B cells that are responding to antigens. However, AID expression and SHM have also been det...

journal_title：Immunity

authors： Han JH,Akira S,Calame K,Beutler B,Selsing E,Imanishi-Kari T

更新日期：2007-07-01 00:00:00

abstract：:Recognition of bacterial peptidoglycan by the Drosophila IMD pathway triggers NF-κB activation and an associated immune response. In this issue of Immunity, Kleino et al. (2017) show that proteins in the IMD pathway form functional amyloids via a cryptic motif resembling the RHIM motif found in mammalian RIPK proteins...

journal_title：Immunity

authors： Shin S,Cherry S

更新日期：2017-10-17 00:00:00

abstract：:Graft-versus-host disease (GVHD) in the gastrointestinal (GI) tract is the principal determinant of lethality following allogeneic bone marrow transplantation (BMT). Here, we examined the mechanisms that initiate GVHD, including the relevant antigen-presenting cells. MHC class II was expressed on intestinal epithelial...

journal_title：Immunity

authors： Koyama M,Mukhopadhyay P,Schuster IS,Henden AS,Hülsdünker J,Varelias A,Vetizou M,Kuns RD,Robb RJ,Zhang P,Blazar BR,Thomas R,Begun J,Waddell N,Trinchieri G,Zeiser R,Clouston AD,Degli-Esposti MA,Hill GR

更新日期：2019-11-19 00:00:00

abstract：:Memory B cells (MBCs) and plasma cells (PCs) constitute the two cellular outputs of germinal center (GC) responses that together facilitate long-term humoral immunity. Although expression of the transcription factor BLIMP-1 identifies cells undergoing PC differentiation, no such marker exists for cells committed to th...

journal_title：Immunity

authors： Suan D,Kräutler NJ,Maag JLV,Butt D,Bourne K,Hermes JR,Avery DT,Young C,Statham A,Elliott M,Dinger ME,Basten A,Tangye SG,Brink R

更新日期：2017-12-19 00:00:00

abstract：:The B cell antigen receptor (BCR) functions to initiate signaling and to internalize antigen for processing from within Lyn kinase-enriched membrane lipid rafts. The signaling function of the BCR is blocked by Epstein-Barr Virus (EBV) latent membrane protein 2A (LMP2A), which is constitutively phosphorylated by Lyn. H...

journal_title：Immunity

authors： Dykstra ML,Longnecker R,Pierce SK

更新日期：2001-01-01 00:00:00

abstract：:TCR transgenic mice that express a peptide antigen in keratinocytes develop a lethal CD8 T cell-dependent autoimmune disease. We employed an adoptive transfer system to understand this disease and show that transfer of low numbers of naive CD8 T cells into peptide transgenic mice caused chronic skin disease. The antig...

journal_title：Immunity

authors： Mayerova D,Parke EA,Bursch LS,Odumade OA,Hogquist KA

更新日期：2004-09-01 00:00:00

abstract：:Eradication of a given pathogen is dependent on the selective differentiation of T helper (Th) cells into Th1 or Th2 types. We show here that T cells from mice lacking the transcription factor IRF-1 fail to mount Th1 responses and instead exclusively undergo Th2 differentiation in vitro. Compromised Th1 differentiatio...

journal_title：Immunity

authors： Taki S,Sato T,Ogasawara K,Fukuda T,Sato M,Hida S,Suzuki G,Mitsuyama M,Shin EH,Kojima S,Taniguchi T,Asano Y

更新日期：1997-06-01 00:00:00

abstract：:Major Histocompatibility Complex (MHC) class II molecules, including Human Leukocyte Antigen (HLA)-DR, present peptide fragments from proteins degraded in the endocytic pathway. HLA-DR is targeted to late-endocytic structures named MHC class II-containing Compartments (MIIC), where it interacts with HLA-DM. This chape...

journal_title：Immunity

authors： Zwart W,Griekspoor A,Kuijl C,Marsman M,van Rheenen J,Janssen H,Calafat J,van Ham M,Janssen L,van Lith M,Jalink K,Neefjes J

更新日期：2005-02-01 00:00:00

abstract：:Neutrophil accumulation is a hallmark of immune complex-mediated inflammatory disorders. Current models of neutrophil recruitment envision the capture of circulating neutrophils by activated endothelial cells. We now demonstrate that immobilized immune complexes alone support the rapid attachment of neutrophils, under...

journal_title：Immunity

authors： Coxon A,Cullere X,Knight S,Sethi S,Wakelin MW,Stavrakis G,Luscinskas FW,Mayadas TN

更新日期：2001-06-01 00:00:00

abstract：:As SARS-CoV-2 infections and death counts continue to rise, it remains unclear why some individuals recover from infection, whereas others rapidly progress and die. Although the immunological mechanisms that underlie different clinical trajectories remain poorly defined, pathogen-specific antibodies often point to imm...

journal_title：Immunity

authors： Atyeo C,Fischinger S,Zohar T,Slein MD,Burke J,Loos C,McCulloch DJ,Newman KL,Wolf C,Yu J,Shuey K,Feldman J,Hauser BM,Caradonna T,Schmidt AG,Suscovich TJ,Linde C,Cai Y,Barouch D,Ryan ET,Charles RC,Lauffenburger D

更新日期：2020-09-15 00:00:00

abstract：:The humoral immune response to protein antigens is composed of a rapid low-affinity IgM antibody response followed by an IgG response exhibiting higher affinity. Here, we demonstrate that Lsc, a protein that regulates G protein-coupled-receptor signaling and RhoA activation, is required by B lymphocytes for the antige...

journal_title：Immunity

authors： Rubtsov A,Strauch P,Digiacomo A,Hu J,Pelanda R,Torres RM

更新日期：2005-11-01 00:00:00

abstract：:The c-Myb transcription factor is crucial during definitive hematopoiesis. However, the embryonic lethality of Myb traditional null mutations has precluded analysis of c-Myb function in lymphocytes. Using tissue-specific inactivation at the Myb locus, we demonstrate that loss of Myb causes a partial block during B cel...

journal_title：Immunity

authors： Thomas MD,Kremer CS,Ravichandran KS,Rajewsky K,Bender TP

更新日期：2005-09-01 00:00:00

abstract：:Although infections with virulent pathogens often induce a strong inflammatory reaction, what drives the increased immune response to pathogens compared to nonpathogenic microbes is poorly understood. One possibility is that the immune system senses the level of threat from a microorganism and augments the response ac...

journal_title：Immunity

authors： Boyer L,Magoc L,Dejardin S,Cappillino M,Paquette N,Hinault C,Charriere GM,Ip WK,Fracchia S,Hennessy E,Erturk-Hasdemir D,Reichhart JM,Silverman N,Lacy-Hulbert A,Stuart LM

更新日期：2011-10-28 00:00:00

abstract：:EBF1 is a pioneer transcription factor involved in B lymphocyte specification. In this issue of Immunity, Wang et al. localize EBF1's pioneering activity to a prion-like domain that mediates recruitment of the nucleosome remodeler Brg1 and FUS-assisted liquid-liquid phase separation. ...

journal_title：Immunity

authors： Kee BL

更新日期：2020-12-15 00:00:00

abstract：:Class-switch recombination (CSR) is a DNA recombination process that replaces the immunoglobulin (Ig) constant region for the isotype that can best protect against the pathogen. Dysregulation of CSR can cause self-reactive BCRs and B cell lymphomas; understanding the timing and location of CSR is therefore important. ...

journal_title：Immunity

authors： Roco JA,Mesin L,Binder SC,Nefzger C,Gonzalez-Figueroa P,Canete PF,Ellyard J,Shen Q,Robert PA,Cappello J,Vohra H,Zhang Y,Nowosad CR,Schiepers A,Corcoran LM,Toellner KM,Polo JM,Meyer-Hermann M,Victora GD,Vinuesa CG

更新日期：2019-08-20 00:00:00