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Peptide antigen treatment of naive and virus-immune mice: antigen-specific tolerance versus immunopathology.

Abstract：

:Peptide-specific down-regulation of T cell responses may represent a powerful tool to intervene in autoimmune diseases or graft rejections. It is therefore important to know whether peptide treatment tolerizes both naive and antigen-experienced memory T lymphocytes. Here we show that a major histocompatibility complex class I binding peptide, derived from the glycoprotein (GP33 peptide) of lymphocytic choriomeningitis virus (LCMV), specifically tolerized naive cytotoxic T lymphocytes (CTL) when administered three times intraperitoneally in incomplete Freund's adjuvants. However, in the presence of GP33-specific memory CTL in LCMV-primed mice, the same treatment had a general immunosuppressive effect on unrelated third-party antigen-specific T cell responses and caused severe immunopathological damage to the spleen.

journal_name

Immunity

journal_title

Immunity

authors

Aichele P,Brduscha-Riem K,Oehen S,Odermatt B,Zinkernagel RM,Hengartner H,Pircher H

doi

10.1016/s1074-7613(00)80340-4

subject

Has Abstract

pub_date

1997-05-01 00:00:00

pages

519-29

issue

5

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(00)80340-4

journal_volume

6

pub_type

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