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PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones.

Abstract：

:Phosphatidylinositol 3' OH kinase (PI3K) signaling and FOXO transcription factors play opposing roles at several B cell developmental stages. We show here abundant nuclear FOXO1 expression in the proliferative compartment of the germinal center (GC), its dark zone (DZ), and PI3K activity, downregulating FOXO1, in the light zone (LZ), where cells are selected for further differentiation. In the LZ, however, FOXO1 was expressed in a fraction of cells destined for DZ reentry. Upon FOXO1 ablation or induction of PI3K activity, GCs lost their DZ, owing at least partly to downregulation of the chemokine receptor CXCR4. Although this prevented proper cyclic selection of cells in GCs, somatic hypermutation and proliferation were maintained. Class switch recombination was partly lost due to a failure of switch region targeting by activation-induced deaminase (AID).

journal_name

Immunity

journal_title

Immunity

authors

Sander S,Chu VT,Yasuda T,Franklin A,Graf R,Calado DP,Li S,Imami K,Selbach M,Di Virgilio M,Bullinger L,Rajewsky K

doi

10.1016/j.immuni.2015.10.021

subject

Has Abstract

pub_date

2015-12-15 00:00:00

pages

1075-86

issue

6

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(15)00446-X

journal_volume

43

pub_type

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