A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or differentiation.

abstract：:Precise intrathymic cell migration is important for thymocyte maturation and organ architecture. The orchestration of thymocyte trafficking, however, is not well understood at a molecular level. Here, we described highly regulated plexinD1 expression on CD4+CD8+ double positive (DP) thymocytes. PlexinD1 expression was...

journal_title：Immunity

authors： Choi YI,Duke-Cohan JS,Ahmed WB,Handley MA,Mann F,Epstein JA,Clayton LK,Reinherz EL

更新日期：2008-12-19 00:00:00

abstract：:Infiltration of regulatory T (Treg) cells into many tumor types correlates with poor patient prognoses. However, mechanisms of intratumoral Treg cell function remain to be elucidated. We investigated Treg cell function in a genetically engineered mouse model of lung adenocarcinoma and found that Treg cells suppressed ...

journal_title：Immunity

authors： Joshi NS,Akama-Garren EH,Lu Y,Lee DY,Chang GP,Li A,DuPage M,Tammela T,Kerper NR,Farago AF,Robbins R,Crowley DM,Bronson RT,Jacks T

更新日期：2015-09-15 00:00:00

abstract：:The investigation of gammadelta T cells has identified a rapid lymphoid stress-surveillance response to microbial and nonmicrobial tissue perturbation. In addition to providing local protection, this response provides an immediate source of cytokines, chemokines, and other functions that can substantially affect downs...

journal_title：Immunity

authors： Hayday AC

更新日期：2009-08-21 00:00:00

abstract：:V(H)-DJ(H) recombination of the immunoglobulin heavy chain (Igh) locus is temporally and spatially controlled during early B cell development, and yet no regulatory elements other than the V(H) gene promoters have been identified throughout the entire V(H) gene cluster. Here, we discovered regulatory sequences that ar...

journal_title：Immunity

authors： Ebert A,McManus S,Tagoh H,Medvedovic J,Salvagiotto G,Novatchkova M,Tamir I,Sommer A,Jaritz M,Busslinger M

更新日期：2011-02-25 00:00:00

abstract：:To define the role of TRAF proteins in CD40-dependent isotype switching in B cells, we introduced wild-type (WT) and mutant CD40 transgenes that lacked the binding motifs for TRAF6 (CD40deltaTRAF6), TRAF2 and TRAF3 (CD40deltaTRAF2/3), or both (CD40deltaTRAFs) into B cells of CD40(-/-) mice. The in vivo isotype switch ...

journal_title：Immunity

authors： Jabara H,Laouini D,Tsitsikov E,Mizoguchi E,Bhan A,Castigli E,Dedeoglu F,Pivniouk V,Brodeur S,Geha R

更新日期：2002-09-01 00:00:00

abstract：:The Toll-like receptor 9 (TLR9) is activated by DNA presented in acidified, intracellular compartments. Previous studies suggested that signaling required unmethylated CpG dinucleotides, but in this issue of Immunity, Haas et al. (2008) challenge this view, showing that DNA can activate TLR9 in a sequence-independent ...

journal_title：Immunity

authors： Gangloff M,Gay NJ

更新日期：2008-03-01 00:00:00

abstract：:For a brief period during fetal lymph node organogenesis in mice, lymph node postcapillary high endothelial venules surprisingly express the Peyer's patch addressin MAdCAM-1. This expression allows initial seeding of this incipient structure by two unusual lymphocyte populations selectively expressing the Peyer's patc...

journal_title：Immunity

authors： Mebius RE,Rennert P,Weissman IL

更新日期：1997-10-01 00:00:00

abstract：:Why patients with chronic kidney disease have elevated cardiovascular risk remains elusive. In this issue of Immunity, Speer et al. (2013) show that natural modification of high density lipoprotein promotes hypertension through a Toll-like receptor-dependent mechanism. ...

journal_title：Immunity

authors： Moore KJ,Fisher EA

更新日期：2013-04-18 00:00:00

abstract：:Macrophage/neutrophil-specific IL-4 receptor alpha-deficient mice (LysM(Cre)IL-4Ralpha(-/flox)) were generated to understand the role of IL-4/IL-13 responsive myeloid cells during Type 2 immune responses. LysM(Cre)IL-4Ralpha(-/flox) mice developed protective immunity against Nippostrongylus brasiliensis accompanied by...

journal_title：Immunity

authors： Herbert DR,Hölscher C,Mohrs M,Arendse B,Schwegmann A,Radwanska M,Leeto M,Kirsch R,Hall P,Mossmann H,Claussen B,Förster I,Brombacher F

更新日期：2004-05-01 00:00:00

abstract：:The Foxp3+ T cell lineage is thought to arise from self-specific precursors during development. By using a unique mouse model, Pacholczyk et al. (2007) present compelling evidence that self-specific cells are exceedingly rare among Foxp3(-) and, surprisingly, Foxp3+ subsets. ...

journal_title：Immunity

authors： Stephens GL,Shevach EM

更新日期：2007-09-01 00:00:00

abstract：:Antigen-presenting cells (APC) degrade proteins intracellularly to generate peptides, which are then bound by products of the major histocompatibility complex (MHC) and exposed on the surface of the APC for recognition by T cells. The supply of antigenic peptides and their association with MHC molecules requires the c...

journal_title：Immunity

authors： Villadangos JA,Ploegh HL

更新日期：2000-03-01 00:00:00

abstract：:Intraepithelial T lymphocytes possess a (TGF beta)-inducible integrin complex that consists of the beta 7 integrin chain in association with a novel alpha chain, murine alpha M290. Using antibodies directed against the murine alpha M290 chain, IL-3-dependent murine bone marrow-derived mast cells demonstrated positive ...

journal_title：Immunity

authors： Smith TJ,Ducharme LA,Shaw SK,Parker CM,Brenner MB,Kilshaw PJ,Weis JH

更新日期：1994-08-01 00:00:00

abstract：:Kupffer cells (KCs) are liver-resident macrophages that self-renew by proliferation in the adult independently from monocytes. However, how they are maintained during non-alcoholic steatohepatitis (NASH) remains ill defined. We found that a fraction of KCs derived from Ly-6C+ monocytes during NASH, underlying impaired...

journal_title：Immunity

authors： Tran S,Baba I,Poupel L,Dussaud S,Moreau M,Gélineau A,Marcelin G,Magréau-Davy E,Ouhachi M,Lesnik P,Boissonnas A,Le Goff W,Clausen BE,Yvan-Charvet L,Sennlaub F,Huby T,Gautier EL

更新日期：2020-09-15 00:00:00

abstract：:The skin barrier is essential for host defense, but how the skin provides protection when the barrier is breached is not well understood. In this issue of Immunity, Gallo and colleagues report that keratinocytes integrate signals from antimicrobial peptides via MAVS signaling to amplify their antiviral immune response...

journal_title：Immunity

authors： Mack MR,Kim BS

更新日期：2016-07-19 00:00:00

abstract：:Activation of the RIG-I signaling molecule is essential for antiviral immunity but mechanisms downmodulating the response are ill defined. In this issue of Immunity, Rajput et al. (2011) describe caspase-8-mediated RIP1 cleavage as a key step for restricting RIG-I signaling. ...

journal_title：Immunity

authors： Roth S,Ruland J

更新日期：2011-03-25 00:00:00

abstract：:The ETS gene Fli-1 is involved in the induction of erythroleukemia in mice by Friend murine leukemia virus and Ewings sarcoma in children. Mice with a targeted null mutation in the Fli-1 locus die at day 11.5 of embryogenesis with loss of vascular integrity leading to bleeding within the vascular plexus of the cerebra...

journal_title：Immunity

authors： Hart A,Melet F,Grossfeld P,Chien K,Jones C,Tunnacliffe A,Favier R,Bernstein A

更新日期：2000-08-01 00:00:00

abstract：:The death domain kinase RIP and the TNF receptor-associated factor 2 (TRAF2) are essential effectors in TNF signaling. To understand the mechanism by which RIP and TRAF2 regulate TNF-induced activation of the transcription factor NF-kappaB, we investigated their respective roles in TNF-R1-mediated IKK activation using...

journal_title：Immunity

authors： Devin A,Cook A,Lin Y,Rodriguez Y,Kelliher M,Liu Z

更新日期：2000-04-01 00:00:00

abstract：:Manipulation of cell death pathways has been identified as a common feature of host-microbe interactions. We examine two examples: influenza A as a representative acute infection and cytomegalovirus as an example of chronic infection. From the perspective of viral entry, replication, and transmission, we identify poin...

journal_title：Immunity

authors： Yatim N,Albert ML

更新日期：2011-10-28 00:00:00

abstract：:Inflammasomes are supramolecular organizing centers that operate to drive interleukin-1 (IL-1)-dependent inflammation. Depending on context, inflammatory caspases act upstream or downstream of inflammasome assembly, serving as the principal enzymes that control activities of these organelles. In this review, we discus...

journal_title：Immunity

authors： Evavold CL,Kagan JC

更新日期：2019-10-15 00:00:00

abstract：:Tissue macrophages arise during embryogenesis from yolk-sac (YS) progenitors that give rise to primitive YS macrophages. Until recently, it has been impossible to isolate or derive sufficient numbers of YS-derived macrophages for further study, but data now suggest that induced pluripotent stem cells (iPSCs) can be dr...

journal_title：Immunity

authors： Takata K,Kozaki T,Lee CZW,Thion MS,Otsuka M,Lim S,Utami KH,Fidan K,Park DS,Malleret B,Chakarov S,See P,Low D,Low G,Garcia-Miralles M,Zeng R,Zhang J,Goh CC,Gul A,Hubert S,Lee B,Chen J,Low I,Shadan NB,Lum J

更新日期：2017-07-18 00:00:00

abstract：:Apoptosis in response to granzyme B involves activation of caspase-dependent target cell death pathways. Herein, we show that granzyme B initiates caspase processing but cannot fully process procaspase-3 in intact Jurkat T leukemia or NT2 neuronal cells. Rather, the release from mitochondria of proapoptotic mediators ...

journal_title：Immunity

authors： Sutton VR,Wowk ME,Cancilla M,Trapani JA

更新日期：2003-03-01 00:00:00

abstract：:Promising vaccines and results from recent clinical trials of therapeutic antibodies against Ebola virus offer hope for an end to this devastating disease. We asked three investigators in the field to share their views on the remaining challenges and important future research directions as we work toward controlling E...

journal_title：Immunity

authors：

更新日期：2019-12-17 00:00:00

abstract：:Cognate interactions of naive T cells with antigen-presenting dendritic cells require physical cell-cell contacts leading to signal induction and T cell activation. Using a three-dimensional collagen matrix videomicroscopy model for ovalbumin peptide-specific activation of murine and oxidative mitogenesis of human T c...

journal_title：Immunity

authors： Gunzer M,Schäfer A,Borgmann S,Grabbe S,Zänker KS,Bröcker EB,Kämpgen E,Friedl P

更新日期：2000-09-01 00:00:00

abstract：:Ikaros family members play an important role in hematopoietic development. Thompson et al. (2007) show that pre-BCR signaling induces Aiolos expression, which in turn suppresses the expression of the pre-BCR component lambda5 and eliminates the very structure that signaled its appearance. ...

journal_title：Immunity

authors： Kioussis D

更新日期：2007-03-01 00:00:00

abstract：:Peptide-specific down-regulation of T cell responses may represent a powerful tool to intervene in autoimmune diseases or graft rejections. It is therefore important to know whether peptide treatment tolerizes both naive and antigen-experienced memory T lymphocytes. Here we show that a major histocompatibility complex...

journal_title：Immunity

authors： Aichele P,Brduscha-Riem K,Oehen S,Odermatt B,Zinkernagel RM,Hengartner H,Pircher H

更新日期：1997-05-01 00:00:00

abstract：:Aryl hydrocarbon receptor (Ahr) is crucial for the maintenance and function of group 3 innate lymphoid cells (ILCs), which are important in gut immunity. Because Ahr promotes T helper 17 (Th17) cell differentiation in vitro, it is reasonable to expect that Ahr would enhance Th17 cells in vivo. Instead, we show that Ah...

journal_title：Immunity

authors： Qiu J,Guo X,Chen ZM,He L,Sonnenberg GF,Artis D,Fu YX,Zhou L

更新日期：2013-08-22 00:00:00

abstract：:Perforation of membranes and pore formation is mediated by polymerization of proteins of the immune system, complement C9 and Perforin, which share the conserved MACPF domain. In this issue of Immunity, Baran et al. (2009) identify the molecular mechanism initiating polymerization as charge interactions in the MACPF d...

journal_title：Immunity

authors： Podack ER

更新日期：2009-05-01 00:00:00

abstract：:The structure of H-2Dd complexed with the HIV-derived peptide P18-I10 (RGPGRAFVTI) has been determined by X-ray crystallography at 2.4 A resolution. This MHC class I molecule has an unusual binding motif with four anchor residues in the peptide (G2, P3, R/K/H5, and I/L/F9 or 10). The cleft architecture of H-2Dd includ...

journal_title：Immunity

authors： Achour A,Persson K,Harris RA,Sundbäck J,Sentman CL,Lindqvist Y,Schneider G,Kärre K

更新日期：1998-08-01 00:00:00

abstract：:Successful organ transplantation requires an optimal innate immune response to avoid tissue injury. In this issue of Immunity, Braza et al. (2018) inhibit pro-inflammatory activation of infiltrating graft macrophages using nanotechnology tools to promote immune tolerance, leading to long-term transplant acceptance in ...

journal_title：Immunity

authors： Pascual-Gil S,Epelman S

更新日期：2018-11-20 00:00:00

abstract：:Invariant chain (Ii)-negative mice exhibit defects in MHC class II assembly and transport that results in reduced levels of surface class II, altered antigen presentation, and inefficient positive selection of CD4+ T cells. Many CD4+ T cells that do mature in Ii-negative mice express a cell surface phenotype consisten...

journal_title：Immunity

authors： Naujokas MF,Arneson LS,Fineschi B,Peterson ME,Sitterding S,Hammond AT,Reilly C,Lo D,Miller J

更新日期：1995-09-01 00:00:00