Aiolos: an ungrateful member of the Ikaros family.

abstract：:Herpes simplex virus type 1 (HSV-1)-infected corneas can develop a blinding immunoinflammatory condition called herpes stromal keratitis (HSK), which involves the loss of corneal sensitivity due to retraction of sensory nerves and subsequent hyperinnervation with sympathetic nerves. Increased concentrations of the cyt...

journal_title：Immunity

authors： Yun H,Yee MB,Lathrop KL,Kinchington PR,Hendricks RL,St Leger AJ

更新日期：2020-11-17 00:00:00

abstract：:After acute inflammation or infection, tissue-resident macrophages are replaced by inflammatory DCs and effector macrophages that arise from circulating monocytes. In this issue of Immunity, Goldszmid et al. (2012) demonstrate a central role for NK cell-derived IFN-γ in signaling and facilitating this transition. ...

journal_title：Immunity

authors： Yap GS,Rivera A

更新日期：2012-06-29 00:00:00

abstract：:Peripheral blood monocytes are a heterogeneous population of circulating leukocytes. Using a murine adoptive transfer system to probe monocyte homing and differentiation in vivo, we identified two functional subsets among murine blood monocytes: a short-lived CX(3)CR1(lo)CCR2(+)Gr1(+) subset that is actively recruited...

journal_title：Immunity

authors： Geissmann F,Jung S,Littman DR

更新日期：2003-07-01 00:00:00

abstract：:The chemokine sink hypothesis pertaining to erythrocyte Duffy Antigen Receptor for Chemokines (DARC) during inflammation has received considerable attention, but lacks direct in vivo evidence. Here we demonstrate, using mice with a targeted deletion in CXCL5, that CXCL5 bound erythrocyte DARC and impaired its chemokin...

journal_title：Immunity

authors： Mei J,Liu Y,Dai N,Favara M,Greene T,Jeyaseelan S,Poncz M,Lee JS,Worthen GS

更新日期：2010-07-23 00:00:00

abstract：:Cytokine signaling via a restricted number of Jak-Stat pathways positively and negatively regulates all cell types involved in the initiation, propagation, and resolution of inflammation. Here, we focus on Jak-Stat signaling in three major cell types involved in inflammatory responses: T cells, neutrophils, and macrop...

journal_title：Immunity

authors： O'Shea JJ,Murray PJ

更新日期：2008-04-01 00:00:00

abstract：:As humans age, their T cell repertoire becomes dominated by cells exhibiting "memory" characteristics. In this issue of Immunity, Su et al. (2013) demonstrate that a large percentage of virus-specific CD4(+) T cells also exhibit a memory phenotype in unexposed adults. ...

journal_title：Immunity

authors： Nolz JC,Harty JT

更新日期：2013-02-21 00:00:00

abstract：:Little is known about the functional differences between the human skin myeloid dendritic cell (DC) subsets, epidermal CD207(+) Langerhans cells (LCs) and dermal CD14(+) DCs. We showed that CD14(+) DCs primed CD4(+) T cells into cells that induce naive B cells to switch isotype and become plasma cells. In contrast, LC...

journal_title：Immunity

authors： Klechevsky E,Morita R,Liu M,Cao Y,Coquery S,Thompson-Snipes L,Briere F,Chaussabel D,Zurawski G,Palucka AK,Reiter Y,Banchereau J,Ueno H

更新日期：2008-09-19 00:00:00

abstract：:Reactive oxygen species (ROS) are generated during T cell activation and serve a signaling function but can also be damaging. In this issue of Immunity, Zhang et al. (2016) show that miR-23a prevents ROS-elicited necrosis by suppressing cyclophilin D (PPIF), a regulator of ROS escape from mitochondria. ...

journal_title：Immunity

authors： Agudo J,Brown BD

更新日期：2016-03-15 00:00:00

abstract：:The peptidoglycan sensor Nod2 and the autophagy protein ATG16L1 have been linked to Crohn's disease (CD). Although Nod2 and the related sensor, Nod1, direct ATG16L1 to initiate anti-bacterial autophagy, whether ATG16L1 affects Nod-driven inflammation has not been examined. Here, we uncover an unanticipated autophagy-i...

journal_title：Immunity

authors： Sorbara MT,Ellison LK,Ramjeet M,Travassos LH,Jones NL,Girardin SE,Philpott DJ

更新日期：2013-11-14 00:00:00

abstract：:Kupffer cells (KCs) are liver-resident macrophages that self-renew by proliferation in the adult independently from monocytes. However, how they are maintained during non-alcoholic steatohepatitis (NASH) remains ill defined. We found that a fraction of KCs derived from Ly-6C+ monocytes during NASH, underlying impaired...

journal_title：Immunity

authors： Tran S,Baba I,Poupel L,Dussaud S,Moreau M,Gélineau A,Marcelin G,Magréau-Davy E,Ouhachi M,Lesnik P,Boissonnas A,Le Goff W,Clausen BE,Yvan-Charvet L,Sennlaub F,Huby T,Gautier EL

更新日期：2020-09-15 00:00:00

abstract：:The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune responses, especially adaptive immune responses to SARS-CoV-2 infection. Here, we collected blood from COVID-19 patients who have recently become virus-free, and therefo...

journal_title：Immunity

authors： Ni L,Ye F,Cheng ML,Feng Y,Deng YQ,Zhao H,Wei P,Ge J,Gou M,Li X,Sun L,Cao T,Wang P,Zhou C,Zhang R,Liang P,Guo H,Wang X,Qin CF,Chen F,Dong C

更新日期：2020-06-16 00:00:00

abstract：:Genetic studies and other experimental data have linked inflammatory bowel diseases with inflammasome activation. In this issue of Immunity, Zaki et al. (2010) and Dupaul-Chicoine et al. (2010) provide a detailed characterization of the regulatory task of the inflammasome in intestinal epithelial cells. ...

journal_title：Immunity

authors： Siegmund B

更新日期：2010-03-26 00:00:00

abstract：:Mouse NK cells express at least seven inhibitory Ly49 receptors. Here we employ a semiquantitative cell-cell adhesion assay as well as class I/peptide tetramers to provide a comprehensive analysis of specificities of Ly49 receptors for class I MHC molecules in eight MHC haplotypes. Different Ly49 receptors exhibited d...

journal_title：Immunity

authors： Hanke T,Takizawa H,McMahon CW,Busch DH,Pamer EG,Miller JD,Altman JD,Liu Y,Cado D,Lemonnier FA,Bjorkman PJ,Raulet DH

更新日期：1999-07-01 00:00:00

abstract：:Following the fate of antigen-specific memory B cells has been difficult. In this issue of Immunity, Krishnamurty et al. (2016) use a novel B cell tetramer to define Plasmodium-specific memory B cells in parasite-infected mice and demonstrate that after re-infection, somatically mutated IgM(+) memory B cells function ...

journal_title：Immunity

authors： Stone SL,Lund FE

更新日期：2016-08-16 00:00:00

abstract：:The ability of human CD1b molecules to present nonpeptide antigens is suggested by the T cell recognition of microbial lipids and lipoglycans in the presence of CD1b-expressing antigen-presenting cells. We demonstrate the high-affinity interaction of CD1b molecules with the acyl side chains of known T cell antigens, l...

journal_title：Immunity

authors： Ernst WA,Maher J,Cho S,Niazi KR,Chatterjee D,Moody DB,Besra GS,Watanabe Y,Jensen PE,Porcelli SA,Kronenberg M,Modlin RL

更新日期：1998-03-01 00:00:00

abstract：:B-lymphoid and myeloid development are markedly perturbed in a unique transgenic mouse strain, max 41. Pro-B, pre-B, and B lymphocytes were severely reduced but granulocytes were greatly elevated. This phenotype could be adoptively transferred with bone marrow cells. It was not alleviated by bcl-2 or myc transgenes th...

journal_title：Immunity

authors： Lindeman GJ,Adams JM,Cory S,Harris AW

更新日期：1994-09-01 00:00:00

abstract：:Multipotential naive CD4(+) T cells differentiate into distinct lineages including T helper 1 (Th1), Th2, Th17, and inducible T regulatory (iTreg) cells. The remarkable diversity of CD4(+) T cells begs the question whether the observed changes reflect terminal differentiation with heritable epigenetic modifications or...

journal_title：Immunity

authors： Wei G,Wei L,Zhu J,Zang C,Hu-Li J,Yao Z,Cui K,Kanno Y,Roh TY,Watford WT,Schones DE,Peng W,Sun HW,Paul WE,O'Shea JJ,Zhao K

更新日期：2009-01-16 00:00:00

abstract：:Chronic inflammatory diseases represent an increasing medical burden, yet neither tools to predict the individual disease course nor causal cures are at hand. We discuss opportunities for systems medicine to derive precise, individualized disease models and outline the European consortium SYSCID as part of the roadmap...

journal_title：Immunity

authors： Schultze JL,SYSCID consortium.,Rosenstiel P

更新日期：2018-04-17 00:00:00

abstract：:Memory CD8+ T cell quantity and quality determine protective efficacy against reinfection. Heterologous prime boost vaccination minimizes contraction of anamnestic effectors and maximizes memory CD8+ T cell quantity but reportedly erodes proliferative potential and protective efficacy. This study exploited heterologou...

journal_title：Immunity

authors： Fraser KA,Schenkel JM,Jameson SC,Vezys V,Masopust D

更新日期：2013-07-25 00:00:00

abstract：:Antigen-dependent T cell activation drives the formation of signaling microclusters containing the adaptor SLP-76. Costimulatory integrins regulate SLP-76 phosphorylation and could influence SLP-76 microclusters in the integrin-rich periphery of the immune synapse. We report that costimulation by the integrin VLA-4 (a...

journal_title：Immunity

authors： Nguyen K,Sylvain NR,Bunnell SC

更新日期：2008-06-01 00:00:00

abstract：:Immunological functions of mast cells are currently considered to be much broader than the original role of mast cells in IgE-driven allergic disease. The spectrum of proposed mast cell functions includes areas as diverse as the regulation of innate and adaptive immune responses, protective immunity against viral, mic...

journal_title：Immunity

authors： Rodewald HR,Feyerabend TB

更新日期：2012-07-27 00:00:00

abstract：:In a recent issue of Nature, Borges da Silva et al. (2018) reveal that P2RX7, a receptor for extracellular ATP, promotes CD8 T cell memory by enhancing metabolic fitness. This work links an ancient "danger" signal with long-term immunity. ...

journal_title：Immunity

authors： Greene TT,Labarta-Bajo L,Zuñiga EI

更新日期：2018-08-21 00:00:00

abstract：:CD4 T cells are pivotal for effective immunity, yet their initial differentiation into effector subsets after infection remains poorly defined. We examined CD4 T cells specific for the immunodominant Leishmania major LACK antigen using MHC/peptide tetramers and IL-4 reporter mice. Comprising approximately 15 cells/lym...

journal_title：Immunity

authors： Stetson DB,Mohrs M,Mallet-Designe V,Teyton L,Locksley RM

更新日期：2002-08-01 00:00:00

abstract：:Glycolysis is linked to the rapid response of memory CD8+ T cells, but the molecular and subcellular structural elements enabling enhanced glucose metabolism in nascent activated memory CD8+ T cells are unknown. We found that rapid activation of protein kinase B (PKB or AKT) by mammalian target of rapamycin complex 2 ...

journal_title：Immunity

authors： Bantug GR,Fischer M,Grählert J,Balmer ML,Unterstab G,Develioglu L,Steiner R,Zhang L,Costa ASH,Gubser PM,Burgener AV,Sauder U,Löliger J,Belle R,Dimeloe S,Lötscher J,Jauch A,Recher M,Hönger G,Hall MN,Romero P,Frez

更新日期：2018-03-20 00:00:00

abstract：:The ETS gene Fli-1 is involved in the induction of erythroleukemia in mice by Friend murine leukemia virus and Ewings sarcoma in children. Mice with a targeted null mutation in the Fli-1 locus die at day 11.5 of embryogenesis with loss of vascular integrity leading to bleeding within the vascular plexus of the cerebra...

journal_title：Immunity

authors： Hart A,Melet F,Grossfeld P,Chien K,Jones C,Tunnacliffe A,Favier R,Bernstein A

更新日期：2000-08-01 00:00:00

abstract：:EBF1 is a pioneer transcription factor involved in B lymphocyte specification. In this issue of Immunity, Wang et al. localize EBF1's pioneering activity to a prion-like domain that mediates recruitment of the nucleosome remodeler Brg1 and FUS-assisted liquid-liquid phase separation. ...

journal_title：Immunity

authors： Kee BL

更新日期：2020-12-15 00:00:00

abstract：:Regulatory T cell-mediated dominant tolerance has been demonstrated to play an important role in the prevention of autoimmunity. Here, we present data arguing that the forkhead transcription factor Foxp3 acts as the regulatory T cell lineage specification factor and mediator of the genetic mechanism of dominant tolera...

journal_title：Immunity

authors： Fontenot JD,Rasmussen JP,Williams LM,Dooley JL,Farr AG,Rudensky AY

更新日期：2005-03-01 00:00:00

abstract：:Phenotypic plasticity of T helper 17 (Th17) cells suggests instability of chromatin structure of key genes of this lineage. We identified epigenetic modifications across the clustered Il17a and Il17f and the Ifng loci before and after differential IL-12 or TGF-beta cytokine signaling, which induce divergent fates of T...

journal_title：Immunity

authors： Mukasa R,Balasubramani A,Lee YK,Whitley SK,Weaver BT,Shibata Y,Crawford GE,Hatton RD,Weaver CT

更新日期：2010-05-28 00:00:00

abstract：:In this issue of Immunity, Schweighoffer et al. (2013) report that full BAFF responsiveness in B cells requires the tyrosine kinase Syk and that BAFF may co-opt components of the B cell receptor in transmitting its survival signal. ...

journal_title：Immunity

authors： Infantino S,Tarlinton DM

更新日期：2013-03-21 00:00:00

abstract：:T follicular helper (Tfh) cells are essential in the induction of high-affinity, class-switched antibodies. The differentiation of Tfh cells is a multi-step process that depends upon the co-receptor ICOS and the activation of phosphoinositide-3 kinase leading to the expression of key Tfh cell genes. We report that ICO...

journal_title：Immunity

authors： Stone EL,Pepper M,Katayama CD,Kerdiles YM,Lai CY,Emslie E,Lin YC,Yang E,Goldrath AW,Li MO,Cantrell DA,Hedrick SM

更新日期：2015-02-17 00:00:00