Abstract：
:The chemokine sink hypothesis pertaining to erythrocyte Duffy Antigen Receptor for Chemokines (DARC) during inflammation has received considerable attention, but lacks direct in vivo evidence. Here we demonstrate, using mice with a targeted deletion in CXCL5, that CXCL5 bound erythrocyte DARC and impaired its chemokine scavenging in blood. CXCL5 increased the plasma concentrations of CXCL1 and CXCL2 in part through inhibiting chemokine scavenging, impairing chemokine gradients and desensitizing CXCR2, which led to decreased neutrophil influx to the lung, increased lung bacterial burden and mortality in an Escherichia coli pneumonia model. In contrast, CXCL5 exerted a predominant role in mediating neutrophil influx to the lung during inflammation after LPS inhalation. Platelets and lung resident cells were the sources of homeostatic CXCL5 in blood and inflammatory CXCL5 in the lung respectively. This study presents a paradigm whereby platelets and red cells alter chemokine scavenging and neutrophil-chemokine interaction during inflammation.
journal_name
Immunityjournal_title
Immunityauthors
Mei J,Liu Y,Dai N,Favara M,Greene T,Jeyaseelan S,Poncz M,Lee JS,Worthen GSdoi
10.1016/j.immuni.2010.07.009subject
Has Abstractpub_date
2010-07-23 00:00:00pages
106-17issue
1eissn
1074-7613issn
1097-4180pii
S1074-7613(10)00251-7journal_volume
33pub_type
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