Abstract：
:To establish whether the widely expressed regulator of Src family kinases Csk contributes to the control of acute inflammation in vivo, we inactivated csk in granulocytes by conditional mutagenesis (Cre/loxP). Mutant mice (Csk-GEcre) developed acute multifocal inflammation in skin and lung. Animals were protected from the disease in a microbiologically controlled environment, but remained hypersensitive to LPS-induced shock. Csk-deficient granulocytes showed enhanced spontaneous and ligand-induced degranulation with hyperinduction of integrins. This hyperresponsiveness was associated with hyperadhesion and impaired migratory responses in vitro. Hyperphosphorylation of key signaling proteins such as Syk and Paxillin in mutant granulocytes further supported breakdown of the activation threshold set by Csk. By enforcing the need for ligand engagement Csk thus prevents premature granulocyte recruitment while supporting the motility of stimulated cells through negative regulation of cell adhesion.
journal_name
Immunityjournal_title
Immunityauthors
Thomas RM,Schmedt C,Novelli M,Choi BK,Skok J,Tarakhovsky A,Roes Jdoi
10.1016/s1074-7613(04)00023-8keywords:
subject
Has Abstractpub_date
2004-02-01 00:00:00pages
181-91issue
2eissn
1074-7613issn
1097-4180pii
S1074-7613(04)00023-8journal_volume
20pub_type
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