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Reactive oxygen species-induced actin glutathionylation controls actin dynamics in neutrophils.

Abstract：

:The regulation of actin dynamics is pivotal for cellular processes such as cell adhesion, migration, and phagocytosis and thus is crucial for neutrophils to fulfill their roles in innate immunity. Many factors have been implicated in signal-induced actin polymerization, but the essential nature of the potential negative modulators are still poorly understood. Here we report that NADPH oxidase-dependent physiologically generated reactive oxygen species (ROS) negatively regulate actin polymerization in stimulated neutrophils via driving reversible actin glutathionylation. Disruption of glutaredoxin 1 (Grx1), an enzyme that catalyzes actin deglutathionylation, increased actin glutathionylation, attenuated actin polymerization, and consequently impaired neutrophil polarization, chemotaxis, adhesion, and phagocytosis. Consistently, Grx1-deficient murine neutrophils showed impaired in vivo recruitment to sites of inflammation and reduced bactericidal capability. Together, these results present a physiological role for glutaredoxin and ROS- induced reversible actin glutathionylation in regulation of actin dynamics in neutrophils.

journal_name

Immunity

journal_title

Immunity

authors

Sakai J,Li J,Subramanian KK,Mondal S,Bajrami B,Hattori H,Jia Y,Dickinson BC,Zhong J,Ye K,Chang CJ,Ho YS,Zhou J,Luo HR

doi

10.1016/j.immuni.2012.08.017

subject

Has Abstract

pub_date

2012-12-14 00:00:00

pages

1037-49

issue

6

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(12)00455-4

journal_volume

37

pub_type

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