当前位置： SCI文献检索 > IMMUNITY期刊下所有文献 > Foxp3 and natural regulatory T cells: key to a cell lineage?

Foxp3 and natural regulatory T cells: key to a cell lineage?

Abstract：

:The recent characterization of a mutant strain of mice generated five decades ago in a program to study ionizing radiation in mammals (and, ironically, derived from a nonmutagenized control animal) is helping to dissect a now resurgent area of immunology. Despite a vast literature during the 1970s, the study of suppressor T cells had been largely abandoned until the publication of several seminal papers rekindled interest in what are today generally referred to as regulatory T (TR) cells. The identification of the transcription factor Foxp3 as the gene responsible for the defect in scurfy mice, and subsequently, the demonstration of its critical involvement in the generation of TR cells, provides an important molecular insight into this essential cell lineage.

journal_name

Immunity

journal_title

Immunity

authors

Ramsdell F

doi

10.1016/s1074-7613(03)00207-3

keywords:

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

165-8

issue

2

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(03)00207-3

journal_volume

19

pub_type

杂志文章,评审

相关文献

IMMUNITY文献大全
  • Distinct Early Serological Signatures Track with SARS-CoV-2 Survival.

    abstract：:As SARS-CoV-2 infections and death counts continue to rise, it remains unclear why some individuals recover from infection, whereas others rapidly progress and die. Although the immunological mechanisms that underlie different clinical trajectories remain poorly defined, pathogen-specific antibodies often point to imm...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2020.07.020

    authors： Atyeo C,Fischinger S,Zohar T,Slein MD,Burke J,Loos C,McCulloch DJ,Newman KL,Wolf C,Yu J,Shuey K,Feldman J,Hauser BM,Caradonna T,Schmidt AG,Suscovich TJ,Linde C,Cai Y,Barouch D,Ryan ET,Charles RC,Lauffenburger D

    更新日期：2020-09-15 00:00:00

  • Positional cloning and molecular characterization of an immunodominant cytotoxic determinant of the mouse H3 minor histocompatibility complex.

    abstract：:Immune responses to minor histocompatibility antigens are poorly understood and present substantial barriers to successful solid tissue and bone marrow transplantation among MHC-matched individuals. We exploited a unique positional cloning approach relying on the potent negative selection capability of cytotoxic T cel...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80666-4

    authors： Zuberi AR,Christianson GJ,Mendoza LM,Shastri N,Roopenian DC

    更新日期：1998-11-01 00:00:00

  • Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.

    abstract：:Null mutations that cripple T cell receptor (TCR) signaling explain rare primary immunodeficiencies, but it is not understood why more common polymorphisms that lead to subtle TCR signaling defects are paradoxically associated with autoimmunity. Here we analyzed how a series of Zap70 variants with step-wise decreases ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2007.11.013

    authors： Siggs OM,Miosge LA,Yates AL,Kucharska EM,Sheahan D,Brdicka T,Weiss A,Liston A,Goodnow CC

    更新日期：2007-12-01 00:00:00

  • Loss of CD47 Makes Dendritic Cells See Red.

    abstract：:Whereas dendritic cells (DCs) can be activated in many ways to trigger immunity, hardly anything is known about the mechanisms that counterbalance DC activation. Cyster and colleagues now demonstrate that the "self" molecule CD47 on erythrocytes critically restricts splenic DC activation. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2015.09.008

    authors： van den Berg TK,van Bruggen R

    更新日期：2015-10-20 00:00:00

  • Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway.

    abstract：:Although infections with virulent pathogens often induce a strong inflammatory reaction, what drives the increased immune response to pathogens compared to nonpathogenic microbes is poorly understood. One possibility is that the immune system senses the level of threat from a microorganism and augments the response ac...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2011.08.015

    authors： Boyer L,Magoc L,Dejardin S,Cappillino M,Paquette N,Hinault C,Charriere GM,Ip WK,Fracchia S,Hennessy E,Erturk-Hasdemir D,Reichhart JM,Silverman N,Lacy-Hulbert A,Stuart LM

    更新日期：2011-10-28 00:00:00

  • Polygenic control of susceptibility to murine systemic lupus erythematosus.

    abstract：:Susceptibility to glomerulonephritis (GN) and anti-dsDNA autoantibody production was analyzed in crosses with a newly developed systemic lupus erythematosus-susceptible inbred strain, NZM/Aeg2410. The mode of inheritance and the number and location of systemic lupus erythematosus-associated susceptibility loci were an...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/1074-7613(94)90100-7

    authors： Morel L,Rudofsky UH,Longmate JA,Schiffenbauer J,Wakeland EK

    更新日期：1994-06-01 00:00:00

  • Frequencies of multiple IgL chain gene rearrangements in single normal or kappaL chain-deficient B lineage cells.

    abstract：:PCR analyses of the kappaL chain locus in single B-lineage cells of wild-type, Ckappa-, or JCkappa-deficient homozygous or heterozygous mice often detect multiple in- and out-of-frame rearrangements at the kappaL and lambdaL loci. They are most frequent in small pre-BII cells and equally so in wild-type and kappaL cha...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80107-7

    authors： Yamagami T,ten Boekel E,Andersson J,Rolink A,Melchers F

    更新日期：1999-09-01 00:00:00

  • Somatic hypermutation in the heavy chain locus correlates with transcription.

    abstract：:Three mutant immunoglobulin heavy chain (IgH) insertion mice were generated in which a targeted nonfunctional IgH passenger transgene was either devoid of promoter (pdelta) or was placed under the transcriptional control of either its own RNA polymerase II-dependent IgH promoter (pII) or a RNA polymerase I-dependent p...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80592-0

    authors： Fukita Y,Jacobs H,Rajewsky K

    更新日期：1998-07-01 00:00:00

  • Natural killer cells activated by MHC class I(low) targets prime dendritic cells to induce protective CD8 T cell responses.

    abstract：:Conserved molecular patterns derived from pathogenic microorganisms prime antigen-presenting dendritic cells (DC) to induce adaptive T cell responses. In contrast, virus-infected or tumor cells that express low levels of major histocompatibility complex (MHC) class I activate natural killer (NK) cells for direct killi...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(03)00264-4

    authors： Mocikat R,Braumüller H,Gumy A,Egeter O,Ziegler H,Reusch U,Bubeck A,Louis J,Mailhammer R,Riethmüller G,Koszinowski U,Röcken M

    更新日期：2003-10-01 00:00:00

  • Toll-like receptor 9, what o'clock is it?

    abstract：:In this issue of Immunity, Silver et al. (2012) provide evidence that murine Toll-like receptor 9 (TLR9) expression and function in innate and adaptive immunity is controlled by the circadian cycle. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2012.02.003

    authors： Obermann HL,Bauer S

    更新日期：2012-02-24 00:00:00

  • The Miami Monkey: A Sunny Alternative to the Berlin Patient.

    abstract：:Curing HIV infection has been impossible, with the exception of the "Berlin Patient." Martinez-Navio et al. (2019) in Miami herein present a rare monkey whose virus was controlled for >3 years after a single genetic intervention that led to persistent production of HIV-neutralizing antibodies in vivo. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2019.02.010

    authors： Liberatore RA,Ho DD

    更新日期：2019-03-19 00:00:00

  • At 17, in-10's passion need not inflame.

    abstract：:In this issue of Immunity, Chaudhry et al. (2011) and Huber et al. (2011) report that control of Th17 cell responses during colonic inflammation requires direct signaling by IL-10 in regulatory T cells and Th17 cells. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2011.04.004

    authors： Stewart CA,Trinchieri G

    更新日期：2011-04-22 00:00:00

  • Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.

    abstract：:Proliferation of memory-phenotype (CD44hi) CD8+ cells induced by infectious agents can be mimicked by injection of type I interferon (IFN I) and by IFN I-inducing agents such as lipopolysaccharide and Poly I:C; such proliferation does not affect naive T cells and appears to be TCR independent. Since IFN I inhibits pro...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80564-6

    authors： Zhang X,Sun S,Hwang I,Tough DF,Sprent J

    更新日期：1998-05-01 00:00:00

  • CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

    abstract：:T cell activation through the TCR can result in either cell proliferation or cell death. The role of costimulatory receptors in regulating T cell survival has not been defined. Here, we present data demonstrating that CD28 costimulation enhances the in vitro survival of activated T cells. One mechanism for this enhanc...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/1074-7613(95)90161-2

    authors： Boise LH,Minn AJ,Noel PJ,June CH,Accavitti MA,Lindsten T,Thompson CB

    更新日期：1995-07-01 00:00:00

  • Instructing B cell fates on the fringe.

    abstract：:The Notch2 ligand DL1 is required for marginal zone B cell development. In this issue of Immunity, Tan et al. (2009) show that modification of Notch2 by Fringe enzymes is critical to maturing B cells for accessing DL1 on vascular endothelial cells. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2009.01.003

    authors： Allman D,Calamito M

    更新日期：2009-02-20 00:00:00

  • The IRF4 Gene Regulatory Module Functions as a Read-Write Integrator to Dynamically Coordinate T Helper Cell Fate.

    abstract：:Transcriptional regulation during CD4+ T cell fate decisions enables their differentiation into distinct states, guiding immune responses toward antibody production via Tfh cells or inflammation by Teff cells. Tfh-Teff cell fate commitment is regulated by mutual antagonism between the transcription factors Bcl6 and Bl...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2017.09.001

    authors： Krishnamoorthy V,Kannanganat S,Maienschein-Cline M,Cook SL,Chen J,Bahroos N,Sievert E,Corse E,Chong A,Sciammas R

    更新日期：2017-09-19 00:00:00

  • Caspases in Cell Death, Inflammation, and Disease.

    abstract：:Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in cell death and inflammation responses. A wealth of foundational insight into the molecular mechanisms that control caspase activation has emerged in recent years. Important advancements include the identification of addi...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2019.05.020

    authors： Van Opdenbosch N,Lamkanfi M

    更新日期：2019-06-18 00:00:00

  • Down-regulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1.

    abstract：:Transcription factors of the NFAT family play a critical role in the immune response by activating the expression of cytokines and other inducible genes in antigen-stimulated cells. Here we show that a member of this family, NFAT1, is involved in down-regulating the late phase of IL-4 gene transcription, thus inhibiti...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80403-3

    authors： Kiani A,Viola JP,Lichtman AH,Rao A

    更新日期：1997-12-01 00:00:00

  • The costimulatory molecule CD27 maintains clonally diverse CD8(+) T cell responses of low antigen affinity to protect against viral variants.

    abstract：:CD70 and CD27 are costimulatory molecules that provide essential signals for the expansion and differentiation of CD8(+) T cells. Here, we show that CD27-driven costimulation lowered the threshold of T cell receptor activation on CD8(+) T cells and enabled responses against low-affinity antigens. Using influenza infec...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2011.04.020

    authors： van Gisbergen KP,Klarenbeek PL,Kragten NA,Unger PP,Nieuwenhuis MB,Wensveen FM,ten Brinke A,Tak PP,Eldering E,Nolte MA,van Lier RA

    更新日期：2011-07-22 00:00:00

  • Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2.

    abstract：:Metabolic engagement is intrinsic to immune cell function. Prostaglandin E2 (PGE2) has been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is unclear. Here, we show that PGE2 caused mitochondrial membrane potential (Δψm) to dissipate in interleukin-4-activated (M(IL-4)) macrophages. Effe...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2018.10.011

    authors： Sanin DE,Matsushita M,Klein Geltink RI,Grzes KM,van Teijlingen Bakker N,Corrado M,Kabat AM,Buck MD,Qiu J,Lawless SJ,Cameron AM,Villa M,Baixauli F,Patterson AE,Hässler F,Curtis JD,O'Neill CM,O'Sullivan D,Wu D,Mittler

    更新日期：2018-12-18 00:00:00

  • Complement is a central mediator of radiotherapy-induced tumor-specific immunity and clinical response.

    abstract：:Radiotherapy induces DNA damage and cell death, but recent data suggest that concomitant immune stimulation is an integral part of the therapeutic action of ionizing radiation. It is poorly understood how radiotherapy supports tumor-specific immunity. Here we report that radiotherapy induced tumor cell death and trans...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2015.03.009

    authors： Surace L,Lysenko V,Fontana AO,Cecconi V,Janssen H,Bicvic A,Okoniewski M,Pruschy M,Dummer R,Neefjes J,Knuth A,Gupta A,van den Broek M

    更新日期：2015-04-21 00:00:00

  • MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota.

    abstract：:Graft-versus-host disease (GVHD) in the gastrointestinal (GI) tract is the principal determinant of lethality following allogeneic bone marrow transplantation (BMT). Here, we examined the mechanisms that initiate GVHD, including the relevant antigen-presenting cells. MHC class II was expressed on intestinal epithelial...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2019.08.011

    authors： Koyama M,Mukhopadhyay P,Schuster IS,Henden AS,Hülsdünker J,Varelias A,Vetizou M,Kuns RD,Robb RJ,Zhang P,Blazar BR,Thomas R,Begun J,Waddell N,Trinchieri G,Zeiser R,Clouston AD,Degli-Esposti MA,Hill GR

    更新日期：2019-11-19 00:00:00

  • Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2.

    abstract：:Myeloid-derived suppressor cells (MDSCs) and cancer stem cells (CSCs) are important cellular components in the cancer microenvironment and may affect cancer phenotype and patient outcome. The nature of MDSCs and their interaction with CSCs in ovarian carcinoma are unclear. We examined the interaction between MDSCs and...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2013.08.025

    authors： Cui TX,Kryczek I,Zhao L,Zhao E,Kuick R,Roh MH,Vatan L,Szeliga W,Mao Y,Thomas DG,Kotarski J,Tarkowski R,Wicha M,Cho K,Giordano T,Liu R,Zou W

    更新日期：2013-09-19 00:00:00

  • Clec2d Joins the Cell Death Sensor Ranks.

    abstract：:Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. In this issue of Immunity, Lai et al. (2020) uncover a role for the C-type lectin receptor Clec2d as a sensor of cell death, which directly detects histones released during necro...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2019.12.015

    authors： Del Fresno C,Sancho D

    更新日期：2020-01-14 00:00:00

  • FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production.

    abstract：:The mechanistic links between genetic variation and autoantibody production in autoimmune disease remain obscure. Autoimmune lymphoproliferative syndrome (ALPS) is caused by inactivating mutations in FAS or FASL, with autoantibodies thought to arise through failure of FAS-mediated removal of self-reactive germinal cen...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2015.04.010

    authors： Butt D,Chan TD,Bourne K,Hermes JR,Nguyen A,Statham A,O'Reilly LA,Strasser A,Price S,Schofield P,Christ D,Basten A,Ma CS,Tangye SG,Phan TG,Rao VK,Brink R

    更新日期：2015-05-19 00:00:00

  • CD95-induced apoptosis of lymphocytes in an immune privileged site induces immunological tolerance.

    abstract：:We examined the relationship between cell death and tolerance induction following antigen injection into the anterior chamber of the eye. Our data show that when inflammatory cells undergo apoptosis following infection with HSV-1, tolerance to the virus was observed. In contrast, when cell death was absent due to defe...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80305-2

    authors： Griffith TS,Yu X,Herndon JM,Green DR,Ferguson TA

    更新日期：1996-07-01 00:00:00

  • Notch signaling regulates antigen sensitivity of naive CD4+ T cells by tuning co-stimulation.

    abstract：:Adaptive immune responses begin when naive CD4(+) T cells engage peptide+major histocompatibility complex class II and co-stimulatory molecules on antigen-presenting cells (APCs). Notch signaling can influence effector functions in differentiated CD4(+) T helper and T regulatory cells. Whether and how ligand-induced N...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2014.12.027

    authors： Laky K,Evans S,Perez-Diez A,Fowlkes BJ

    更新日期：2015-01-20 00:00:00

  • Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals.

    abstract：:Inflammation can activate self-reactive CD8(+) T cells and induce autoimmunity. Here we show in a CD8(+) T cell-mediated model of type 1 diabetes that CD4(+)CD25(+) Treg cells prevent beta cell destruction following localized inflammation in the islets of Langerhans. These Treg cells accumulate preferentially in the p...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(02)00279-0

    authors： Green EA,Choi Y,Flavell RA

    更新日期：2002-02-01 00:00:00

  • Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2.

    abstract：:Human memory B cells that carry mutated IgV region genes were isolated from tonsils by negative selection of IgD+ naive B cells and CD38+ germinal center B cells and plasma cells. They were mainly found within the intraepithelial areas, but not in the B cell follicles of human tonsils. Memory B cells but not naive B c...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/1074-7613(95)90048-9

    authors： Liu YJ,Barthélémy C,de Bouteiller O,Arpin C,Durand I,Banchereau J

    更新日期：1995-03-01 00:00:00

  • Monocyte-Derived Macrophages: The Missing Link in Organ Transplantation.

    abstract：:Successful organ transplantation requires an optimal innate immune response to avoid tissue injury. In this issue of Immunity, Braza et al. (2018) inhibit pro-inflammatory activation of infiltrating graft macrophages using nanotechnology tools to promote immune tolerance, leading to long-term transplant acceptance in ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2018.11.005

    authors： Pascual-Gil S,Epelman S

    更新日期：2018-11-20 00:00:00