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The costimulatory molecule CD27 maintains clonally diverse CD8(+) T cell responses of low antigen affinity to protect against viral variants.

Abstract：

:CD70 and CD27 are costimulatory molecules that provide essential signals for the expansion and differentiation of CD8(+) T cells. Here, we show that CD27-driven costimulation lowered the threshold of T cell receptor activation on CD8(+) T cells and enabled responses against low-affinity antigens. Using influenza infection to study in vivo consequences, we found that CD27-driven costimulation promoted a CD8(+) T cell response of overall low affinity. These qualitative effects of CD27 on T cell responses were maintained into the memory phase. On a clonal level, CD27-driven costimulation established a higher degree of variety in memory CD8(+) T cells. The benefit became apparent when mice were reinfected, given that CD27 improved CD8(+) T cell responses against reinfection with viral variants, but not with identical virus. We propose that CD27-driven costimulation is a strategy to generate memory clones that have potential reactivity to a wide array of mutable pathogens.

journal_name

Immunity

journal_title

Immunity

authors

van Gisbergen KP,Klarenbeek PL,Kragten NA,Unger PP,Nieuwenhuis MB,Wensveen FM,ten Brinke A,Tak PP,Eldering E,Nolte MA,van Lier RA

doi

10.1016/j.immuni.2011.04.020

subject

Has Abstract

pub_date

2011-07-22 00:00:00

pages

97-108

issue

1

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(11)00266-4

journal_volume

35

pub_type

杂志文章

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