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Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells.

Abstract：

:By stimulating human lymphocytes with an autologous renal carcinoma, we obtained CTL recognizing an antigen derived from a novel, ubiquitous protein. The CTL failed to lyse autologous EBV-transformed B cells, even though the latter express the protein. This is due to the presence in these cells of immunoproteasomes, which, unlike standard proteasomes, cannot produce the antigenic peptide. We show that dendritic cells also carry immunoproteasomes and fail to present this antigen. This may explain why the relevant CTL escape thymic deletion and are not regularly activated in the periphery. Lack of cleavage by the immunoproteasome was also observed for melanoma differentiation antigen Melan-A26-35/HLA-A2, currently used for antitumoral vaccination. For immunization with such antigens, proteins should be less suitable than peptides, which do not require proteasome digestion in dendritic cells.

journal_name

Immunity

journal_title

Immunity

authors

Morel S,Lévy F,Burlet-Schiltz O,Brasseur F,Probst-Kepper M,Peitrequin AL,Monsarrat B,Van Velthoven R,Cerottini JC,Boon T,Gairin JE,Van den Eynde BJ

doi

10.1016/s1074-7613(00)80163-6

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

107-17

issue

1

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(00)80163-6

journal_volume

12

pub_type

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