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Positional cloning and molecular characterization of an immunodominant cytotoxic determinant of the mouse H3 minor histocompatibility complex.

Abstract：

:Immune responses to minor histocompatibility antigens are poorly understood and present substantial barriers to successful solid tissue and bone marrow transplantation among MHC-matched individuals. We exploited a unique positional cloning approach relying on the potent negative selection capability of cytotoxic T cells to identify the H3a gene responsible for immunodominant H2-Db-restricted determinants of the classically defined mouse autosomal H3 complex. The allelic basis for reciprocal H3a antigens is two amino acid changes within a single nonamer H2-Db-binding peptide. The H3a gene, now called Zfp106, encodes a 1888-amino acid protein with three zinc fingers and a beta-transducin domain consistent with DNA/protein binding. A region of ZFP106 is identical to a 600-amino acid sequence implicated in the insulin receptor signaling pathway.

journal_name

Immunity

journal_title

Immunity

authors

Zuberi AR,Christianson GJ,Mendoza LM,Shastri N,Roopenian DC

doi

10.1016/s1074-7613(00)80666-4

subject

Has Abstract

pub_date

1998-11-01 00:00:00

pages

687-98

issue

5

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(00)80666-4

journal_volume

9

pub_type

杂志文章

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