Abstract:
:Fas receptor-induced apoptosis plays critical roles in immune homeostasis. However, most of the signal transduction events distal to Fas ligation have not been elucidated. Here, we show that Ras is activated following ligation of Fas on lymphoid lines. The activation of Ras is a critical component of this apoptotic pathway, since inhibition of Ras by neutralizing antibody or a dominant-negative Ras mutant interfered with Fas-induced apoptosis. Furthermore, ligation of Fas also resulted in stimulation of the sphingomyelin signalling pathway to produce ceramides, which, in turn, are capable of inducing both Ras activation and apoptosis. This suggests that ceramides acts as second messengers in Fas signaling via Ras. Thus, ligation of the Fas molecule on lymphocyte lines induces activation of Ras via the action of ceramide, and this activation is necessary, but not sufficient, for subsequent apoptosis.
journal_name
Immunityjournal_title
Immunityauthors
Gulbins E,Bissonnette R,Mahboubi A,Martin S,Nishioka W,Brunner T,Baier G,Baier-Bitterlich G,Byrd C,Lang Fdoi
10.1016/1074-7613(95)90142-6subject
Has Abstract,Author List Incompletepub_date
1995-04-01 00:00:00pages
341-51issue
4eissn
1074-7613issn
1097-4180pii
1074-7613(95)90142-6journal_volume
2pub_type
杂志文章相关文献
IMMUNITY文献大全abstract::Cytokine regulation of B cell development was analyzed using interleukin-2 (IL-2)-induced transcription of the J chain gene as a model system. A nuclear target of the IL-2 signal was identified as the Pax5 transcription factor, BSAP, which recognizes a negative regulatory motif in the J chain promoter. Functional assa...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80263-0
更新日期:1996-10-01 00:00:00
abstract::Acute lung injury (ALI) remains a serious health issue with little improvement in our understanding of the pathophysiology and therapeutic approaches. We investigated the mechanism that lipopolysaccharide (LPS) induces early neutrophil recruitment to lungs and increases pulmonary vascular permeability during ALI. Intr...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.03.007
更新日期:2015-04-21 00:00:00
abstract::Using a transgenic approach, we examined distal regulatory elements located in the IL-4 locus and the role of GATA-3 at these elements. The intergenic DNase I hypersensitive sites (HSS) showed strong enhancement, and the intronic enhancer (IE) and HS5/HS5a sites showed weaker enhancement of the IL-4 promoter. Elements...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(01)00125-x
更新日期:2001-04-01 00:00:00
abstract::Transcription factors of the NFAT family play a critical role in the immune response by activating the expression of cytokines and other inducible genes in antigen-stimulated cells. Here we show that a member of this family, NFAT1, is involved in down-regulating the late phase of IL-4 gene transcription, thus inhibiti...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80403-3
更新日期:1997-12-01 00:00:00
abstract::Aire promotes the tolerization of thymocytes by inducing the expression of a battery of peripheral-tissue antigens in thymic medullary epithelial cells. We demonstrate that the cellular mechanism by which Aire exerts its tolerance-promoting function is not primarily positive selection of regulatory T cells, but rather...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2005.07.005
更新日期:2005-08-01 00:00:00
abstract::The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) family of pattern-recognition molecules mediate host immunity to various pathogenic stimuli. However, in vivo evidence for the involvement of NLR proteins in viral sensing has not been widely investigated and remains controversial. As a test of the...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2009.02.005
更新日期:2009-04-17 00:00:00
abstract::MicroRNA (miRNA)-deficient helper T cells exhibit abnormal IFN-γ production and decreased proliferation. However, the contributions of individual miRNAs to this phenotype remain poorly understood. We conducted a screen for miRNA function in primary T cells and identified individual miRNAs that rescue the defects assoc...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2011.07.009
更新日期:2011-08-26 00:00:00
abstract::In T cell-dependent immune responses, high-affinity B cells are selected and differentiate into memory cells; however, the mechanism behind this process remains largely unknown. Here, we report that the selection of high-affinity B cells within germinal centers (GCs) is impaired in Fas-deficient lpr mice in the primar...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(01)00100-5
更新日期:2001-02-01 00:00:00
abstract::Active research at the frontiers of immunology and neuroscience has identified multiple points of interaction and communication between the immune system and the nervous system. Immune cell activation stimulates neuronal circuits that regulate innate and adaptive immunity. Molecular mechanistic insights into the infla...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2017.06.008
更新日期:2017-06-20 00:00:00
abstract::Assembly of inflammasomes after infection or injury leads to the release of interleukin-1β (IL-1β) and to pyroptosis. After inflammasome activation, cells either pyroptose or enter a hyperactivated state defined by IL-1β secretion without cell death, but what controls these different outcomes is unknown. Here, we show...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2019.04.005
更新日期:2019-06-18 00:00:00
abstract::Promising vaccines and results from recent clinical trials of therapeutic antibodies against Ebola virus offer hope for an end to this devastating disease. We asked three investigators in the field to share their views on the remaining challenges and important future research directions as we work toward controlling E...
journal_title:Immunity
pub_type: 社论
doi:10.1016/j.immuni.2019.11.010
更新日期:2019-12-17 00:00:00
abstract::The transcriptional repressor Id2 is constitutively expressed in all innate lymphoid cells (ILCs) and is required for their development. In this issue of Immunity, Mowel et al. (2017) demonstrate that Id2 expression is regulated by a cell type-specific cis-regulatory element in group 1 ILCs that is demarcated by a lon...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2017.08.019
更新日期:2017-09-19 00:00:00
abstract::The tolerogenic microenvironment of the liver is associated with impaired hepatic T cell function. Here, we examined the contribution of liver-resident natural killer (LrNK) cells, a prominent hepatic NK cell compartment, to T cell antiviral responses in the liver. The number of virus-specific T cells increased in LrN...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.12.024
更新日期:2019-02-19 00:00:00
abstract::Inhibition of immune regulatory checkpoints, such as CTLA-4 and the PD-1-PD-L1 axis, is at the forefront of immunotherapy for cancers of various histological types. However, such immunotherapies fail to control neoplasia in a significant proportion of patients. Here, we review how a range of cancer-cell-autonomous cue...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2016.06.001
更新日期:2016-06-21 00:00:00
abstract::Antibodies against the NANP repeat of circumsporozoite protein (CSP), the major surface antigen of Plasmodium falciparum (Pf) sporozoites, can protect from malaria in animal models but protective humoral immunity is difficult to induce in humans. Here we cloned and characterized rare affinity-matured human NANP-reacti...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.11.007
更新日期:2017-12-19 00:00:00
abstract::The cause of common polygenic autoimmune diseases is not understood because of genetic and cellular complexity. Here, we pinpoint the action of a subset of autoimmune susceptibility loci in the NOD mouse strain linked to D1mit181, D2mit490, D7mit101, and D15mit229, which cause a generalized resistance to thymic deleti...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2004.10.014
更新日期:2004-12-01 00:00:00
abstract::Epstein-Barr virus (EBV) establishes a persistent latent infection in peripheral B lymphocytes in humans and is associated with a variety of malignancies and proliferative disorders. Latent membrane protein 2A (LMP2A) is one of only two viral proteins expressed in latently infected B lymphocytes in vivo. LMP2A blocks ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80623-8
更新日期:1998-09-01 00:00:00
abstract::Metabolic engagement is intrinsic to immune cell function. Prostaglandin E2 (PGE2) has been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is unclear. Here, we show that PGE2 caused mitochondrial membrane potential (Δψm) to dissipate in interleukin-4-activated (M(IL-4)) macrophages. Effe...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.10.011
更新日期:2018-12-18 00:00:00
abstract::Activation of the transcription factor NF-kappa B and pre-T cell receptor (pre-TCR) expression is tightly correlated during thymocyte development. Inhibition of NF-kappa B in isolated thymocytes in vitro results in spontaneous apoptosis of cells expressing the pre-TCR, whereas inhibition of NF-kappa B in transgenic mi...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)00067-4
更新日期:2000-11-01 00:00:00
abstract::How antigen valency affects B cells in vivo during immune responses is not well understood. Here, using HIV immunogens with defined valencies ranging from 1 to 60, we investigated the role of antigen valency during different phases of B cell responses in vivo. Highly multimerized immunogens preferentially rapidly acti...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2020.08.001
更新日期:2020-09-15 00:00:00
abstract::The investigation of gammadelta T cells has identified a rapid lymphoid stress-surveillance response to microbial and nonmicrobial tissue perturbation. In addition to providing local protection, this response provides an immediate source of cytokines, chemokines, and other functions that can substantially affect downs...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2009.08.006
更新日期:2009-08-21 00:00:00
abstract::Specification of the T helper 17 (Th17) cell lineage requires a well-defined set of transcription factors, but how these integrate with posttranscriptional and epigenetic programs to regulate gene expression is poorly understood. Here we found defective Th17 cell cytokine expression in miR-155-deficient CD4+ T cells i...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2014.03.014
更新日期:2014-06-19 00:00:00
abstract::Indoleamine 2,3 dioxygenase (IDO) catabolizes the amino acid tryptophan. IDO-expressing immunoregulatory dendritic cells (DCs) have been implicated in settings including tumors, autoimmunity, and transplant tolerance. However, the downstream molecular mechanisms by which IDO functions to regulate T cell responses rema...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2005.03.013
更新日期:2005-05-01 00:00:00
abstract::EBF1 is a pioneer transcription factor involved in B lymphocyte specification. In this issue of Immunity, Wang et al. localize EBF1's pioneering activity to a prion-like domain that mediates recruitment of the nucleosome remodeler Brg1 and FUS-assisted liquid-liquid phase separation. ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2020.11.013
更新日期:2020-12-15 00:00:00
abstract::In this issue of Immunity, Mrdjen et al. (2018) use high-dimensional single-cell proteomics and high parametric mass cytometry to provide insight into the long-lasting issue of how to identify and characterize both resident and recruited leukocyte populations in healthy, aged, and diseased CNS. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2018.02.009
更新日期:2018-02-20 00:00:00
abstract::Memory lymphocytes are characterized by their ability to exhibit a rapid response to the recall antigen, in which differential transcription is important, yet the underlying mechanism is not understood. We report here a genome-wide analysis of histone methylation on two histone H3 lysine residues (H3K4me3 and H3K27me3...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2009.05.006
更新日期:2009-06-19 00:00:00
abstract::We examined the relationship between cell death and tolerance induction following antigen injection into the anterior chamber of the eye. Our data show that when inflammatory cells undergo apoptosis following infection with HSV-1, tolerance to the virus was observed. In contrast, when cell death was absent due to defe...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80305-2
更新日期:1996-07-01 00:00:00
abstract::Cdc42 and WASP are critical regulators of actin polymerization whose function during T cell signaling is poorly understood. Using a novel reagent that specifically detects Cdc42-GTP in fixed cells, we found that activated Cdc42 localizes to the T cell:APC contact site in an antigen-dependent manner. TCR signaling alon...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(01)00178-9
更新日期:2001-08-01 00:00:00
abstract::The mammalian gut microbiota provides essential metabolites to the host and promotes the differentiation and accumulation of extrathymically generated regulatory T (pTreg) cells. To explore the impact of these cells on intestinal microbial communities, we assessed the composition of the microbiota in pTreg cell-defici...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.04.013
更新日期:2018-06-19 00:00:00
abstract::Asthma is a chronic inflammatory airway disease associated with type 2 cytokines interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus overproduction, bronchial hyperresponsiveness (BHR), and immunogloubulin E (IgE) synthesis. However, only half of asthma patients exhibit signs of an exacerba...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2019.03.018
更新日期:2019-04-16 00:00:00