Abstract：
:How antigen valency affects B cells in vivo during immune responses is not well understood. Here, using HIV immunogens with defined valencies ranging from 1 to 60, we investigated the role of antigen valency during different phases of B cell responses in vivo. Highly multimerized immunogens preferentially rapidly activated cognate B cells, with little affinity discrimination. This led to strong early induction of the transcription factors IRF4 (interferon regulatory factor 4) and Bcl6, driving both early extrafollicular plasma cell and germinal center responses, in a CD4+ T-cell-dependent manner, involving B cells with a broad range of affinities. Low-valency antigens induced smaller effector B cell responses, with preferential recruitment of high-affinity B cells. Thus, antigen valency has multifaceted effects on B cell responses and can dictate affinity thresholds and competitive landscapes for B cells in vivo, with implications for vaccine design.
journal_name
Immunityjournal_title
Immunityauthors
Kato Y,Abbott RK,Freeman BL,Haupt S,Groschel B,Silva M,Menis S,Irvine DJ,Schief WR,Crotty Sdoi
10.1016/j.immuni.2020.08.001subject
Has Abstractpub_date
2020-09-15 00:00:00pages
548-563.e8issue
3eissn
1074-7613issn
1097-4180pii
S1074-7613(20)30334-4journal_volume
53pub_type
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