当前位置： SCI文献检索 > IMMUNITY期刊下所有文献 > Fas is required for clonal selection in germinal centers and the subsequent establishment of the memory B cell repertoire.

Fas is required for clonal selection in germinal centers and the subsequent establishment of the memory B cell repertoire.

Abstract：

:In T cell-dependent immune responses, high-affinity B cells are selected and differentiate into memory cells; however, the mechanism behind this process remains largely unknown. Here, we report that the selection of high-affinity B cells within germinal centers (GCs) is impaired in Fas-deficient lpr mice in the primary response, probably owing to inefficient negative selection. The memory compartment in control mice is mostly established by precursors generated from the early GCs, whereas the lpr defect expands the memory compartment by the increased recruitment of newly generated precursors from the late GCs, resulting in the accumulation of heavily mutated memory B cells at high frequency. These results suggest that Fas is required for clonal selection within GCs and the establishment of the memory B cell repertoire.

journal_name

Immunity

journal_title

Immunity

authors

Takahashi Y,Ohta H,Takemori T

doi

10.1016/s1074-7613(01)00100-5

keywords:

subject

Has Abstract

pub_date

2001-02-01 00:00:00

pages

181-92

issue

2

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(01)00100-5

journal_volume

14

pub_type

杂志文章

相关文献

IMMUNITY文献大全
  • Immune-cell lineage commitment: translation from mice to humans.

    abstract：:Much of the current understanding in hematopoietic stem cell differentiation into immune-cell lineages comes from mouse studies, but how well does it translate to the human system? ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2007.05.011

    authors： Payne KJ,Crooks GM

    更新日期：2007-06-01 00:00:00

  • Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.

    abstract：:T cell activation induces functional changes in cell shape and cytoskeletal architecture. To facilitate the collection of dynamic, high-resolution images of activated T cells, we plated T cells on coverslips coated with antibodies to the T cell receptor (TCR). Using these images, we were able to quantitate the morphol...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(01)00112-1

    authors： Bunnell SC,Kapoor V,Trible RP,Zhang W,Samelson LE

    更新日期：2001-03-01 00:00:00

  • Recognition of pneumococcal peptidoglycan: an expanded, pivotal role for LPS binding protein.

    abstract：:Lipopolysaccharide binding protein (LBP) has a well-established role in LPS-induced immune responses. Here, we report that LBP also plays an essential role in the innate immune response to Gram-positive pneumococci, specifically to their major inflammatory component, pneumococcal cell wall (PCW). LBP was present in th...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(03)00205-x

    authors： Weber JR,Freyer D,Alexander C,Schröder NW,Reiss A,Küster C,Pfeil D,Tuomanen EI,Schumann RR

    更新日期：2003-08-01 00:00:00

  • Targeting the function of mature dendritic cells by human cytomegalovirus: a multilayered viral defense strategy.

    abstract：:Human cytomegalovirus (HCMV) can suppress and evade the immune system. We have identified as a mechanism the ability of HCMV to infect dendritic cells (DC), which initiate the antiviral immune response. HCMV-infected DC show enhanced expression of costimulatory molecules. In contrast, MHC molecules are partially downr...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(01)00239-4

    authors： Raftery MJ,Schwab M,Eibert SM,Samstag Y,Walczak H,Schönrich G

    更新日期：2001-12-01 00:00:00

  • Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.

    abstract：:The cause of common polygenic autoimmune diseases is not understood because of genetic and cellular complexity. Here, we pinpoint the action of a subset of autoimmune susceptibility loci in the NOD mouse strain linked to D1mit181, D2mit490, D7mit101, and D15mit229, which cause a generalized resistance to thymic deleti...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2004.10.014

    authors： Liston A,Lesage S,Gray DH,O'Reilly LA,Strasser A,Fahrer AM,Boyd RL,Wilson J,Baxter AG,Gallo EM,Crabtree GR,Peng K,Wilson SR,Goodnow CC

    更新日期：2004-12-01 00:00:00

  • Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob.

    abstract：:Select humans and animals control persistent viral infections via adaptive immune responses that include production of neutralizing antibodies. The precise genetic basis for the control remains enigmatic. Here, we report positional cloning of the gene responsible for production of retrovirus-neutralizing antibodies in...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2017.07.013

    authors： Denzin LK,Khan AA,Virdis F,Wilks J,Kane M,Beilinson HA,Dikiy S,Case LK,Roopenian D,Witkowski M,Chervonsky AV,Golovkina TV

    更新日期：2017-08-15 00:00:00

  • Neutrophil Extracellular Traps Initiate Gallstone Formation.

    abstract：:The presence of gallstones (cholelithiasis) is a highly prevalent and severe disease and one of the leading causes of hospital admissions worldwide. Due to its substantial health impact, we investigated the biological mechanisms that lead to the formation and growth of gallstones. We show that gallstone assembly essen...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2019.07.002

    authors： Muñoz LE,Boeltz S,Bilyy R,Schauer C,Mahajan A,Widulin N,Grüneboom A,Herrmann I,Boada E,Rauh M,Krenn V,Biermann MHC,Podolska MJ,Hahn J,Knopf J,Maueröder C,Paryzhak S,Dumych T,Zhao Y,Neurath MF,Hoffmann MH,Fuchs T

    更新日期：2019-09-17 00:00:00

  • Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction.

    abstract：:CD4+ T cells orchestrate immune responses and destruction of allogeneic organ transplants, but how this process is regulated on a transcriptional level remains unclear. Here, we demonstrated that interferon regulatory factor 4 (IRF4) was a key transcriptional determinant controlling T cell responses during transplanta...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2017.11.003

    authors： Wu J,Zhang H,Shi X,Xiao X,Fan Y,Minze LJ,Wang J,Ghobrial RM,Xia J,Sciammas R,Li XC,Chen W

    更新日期：2017-12-19 00:00:00

  • We Can Still Be Friends: IFN-γ Breaks Up Macrophage Enhancers.

    abstract：:Interferon (IFN)-γ can prime macrophages for inflammatory responses by several mechanisms, including enhancer establishment and gene activation. In this issue of Immunity, Kang et al. (2017) provide insight into the mechanisms of IFN-γ-mediated gene repression as they show that IFN-γ promotes the disassembly of select...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2017.08.002

    authors： Novakovic B,Wang C,Logie C

    更新日期：2017-08-15 00:00:00

  • AMPK helps T cells survive nutrient starvation.

    abstract：:Reprogramming of cellular metabolism is crucial for T cells responding to environmental cues. Blagih et al. (2015) reveal that the kinase AMPK directs metabolic adaption of effector T cells upon nutrient limitation and contributes to immune responses in vivo. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2014.12.029

    authors： Yang K,Chi H

    更新日期：2015-01-20 00:00:00

  • Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus.

    abstract：:Immunity to the intestinal parasite Heligomosomoides polygyrus is dependent on the successful generation of T helper 2 (Th2) memory cells. We showed that B cells contribute to immunity against H. polygyrus by producing antibody (Ab) and by promoting expansion and differentiation of primary and memory Th2 cells. We als...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2009.01.006

    authors： Wojciechowski W,Harris DP,Sprague F,Mousseau B,Makris M,Kusser K,Honjo T,Mohrs K,Mohrs M,Randall T,Lund FE

    更新日期：2009-03-20 00:00:00

  • A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis.

    abstract：:T cell receptor (TCR) transgenic mice specific for hen egg lysozyme (HEL) were crossed with mice expressing HEL on the thyroid epithelium, on pancreatic islet beta cells, or systemically. Depending on the pattern of HEL expression, deletion of double-positive thymocytes ranged from minimal to complete, and peripheral ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80528-2

    authors： Akkaraju S,Ho WY,Leong D,Canaan K,Davis MM,Goodnow CC

    更新日期：1997-08-01 00:00:00

  • Plasticity of T cell memory responses to viruses.

    abstract：:Virus-specific memory T cell populations demonstrate plasticity in antigenic and functional phenotype, in recognition of antigen, and in their ability to accommodate new memory T cell populations. The adaptability of complex antigen-specific T cell repertoires allows the host to respond to a diverse array of pathogens...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/s1074-7613(03)00356-x

    authors： Selin LK,Welsh RM

    更新日期：2004-01-01 00:00:00

  • A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or differentiation.

    abstract：:To investigate the specificity of cytokine signals in hematopoietic differentiation, we generated mice with a targeted mutation of their G-CSF receptor (G-CSFR) such that the cytoplasmic (signaling) domain of the G-CSFR is replaced with the cytoplasmic domain of the erythropoietin receptor. In homozygous mutant mice, ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80090-4

    authors： Semerad CL,Poursine-Laurent J,Liu F,Link DC

    更新日期：1999-08-01 00:00:00

  • Bon EPOtit! S1P-Mediated EPO Signaling Whets a Macrophage's Appetite for Apoptotic Cells.

    abstract：:Phagocytes clear dying cells within an organism to prevent damaging inflammation and autoimmunity. In this issue of Immunity, Luo et al. (2016) describe how "find-me" signals from apoptotic cells induce erythropoietin signaling within macrophages to prime them for efferocytosis. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2016.01.023

    authors： Kolb JP,Martinez J

    更新日期：2016-02-16 00:00:00

  • The Birds, the Bees, and Innate Immunity.

    abstract：:The cytoplasm is usually a DNA-free zone, but during fertilization, sperm DNA enters oocyte cytoplasm and could potentially trigger a response. Abe et al. (2017) identify NLRP14 as a germ-cell-specific negative regulator of DNA sensing that may be of particular importance during fertilization. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2017.04.002

    authors： Barber GN

    更新日期：2017-04-18 00:00:00

  • Unexpected steps in plasma-cell differentiation.

    abstract：:The transcriptional repressor Blimp-1 is considered the master regulator of plasma-cell differentiation. In this issue of Immunity, Kallies et al. (2007) identify a Blimp-1-independent stage of differentiation, followed by Blimp-1-dependent terminal differentiation. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2007.05.005

    authors： Klein U,Dalla-Favera R

    更新日期：2007-05-01 00:00:00

  • Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function.

    abstract：:Tissue macrophages arise during embryogenesis from yolk-sac (YS) progenitors that give rise to primitive YS macrophages. Until recently, it has been impossible to isolate or derive sufficient numbers of YS-derived macrophages for further study, but data now suggest that induced pluripotent stem cells (iPSCs) can be dr...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2017.06.017

    authors： Takata K,Kozaki T,Lee CZW,Thion MS,Otsuka M,Lim S,Utami KH,Fidan K,Park DS,Malleret B,Chakarov S,See P,Low D,Low G,Garcia-Miralles M,Zeng R,Zhang J,Goh CC,Gul A,Hubert S,Lee B,Chen J,Low I,Shadan NB,Lum J

    更新日期：2017-07-18 00:00:00

  • microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells.

    abstract：:microRNA-155 (miR-155) is expressed by cells of the immune system after activation and has been shown to be required for antibody production after vaccination with attenuated Salmonella. Here we show the intrinsic requirement for miR-155 in B cell responses to thymus-dependent and -independent antigens. B cells lackin...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2007.10.009

    authors： Vigorito E,Perks KL,Abreu-Goodger C,Bunting S,Xiang Z,Kohlhaas S,Das PP,Miska EA,Rodriguez A,Bradley A,Smith KG,Rada C,Enright AJ,Toellner KM,Maclennan IC,Turner M

    更新日期：2007-12-01 00:00:00

  • Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells.

    abstract：:Fever, an evolutionarily conserved physiological response to infection, is also commonly associated with many autoimmune diseases, but its role in T cell differentiation and autoimmunity remains largely unclear. T helper 17 (Th17) cells are critical in host defense and autoinflammatory diseases, with distinct phenotyp...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2020.01.006

    authors： Wang X,Ni L,Wan S,Zhao X,Ding X,Dejean A,Dong C

    更新日期：2020-02-18 00:00:00

  • T follicular helper cell differentiation, function, and roles in disease.

    abstract：:Follicular helper T (Tfh) cells are specialized providers of T cell help to B cells, and are essential for germinal center formation, affinity maturation, and the development of most high-affinity antibodies and memory B cells. Tfh cell differentiation is a multistage, multifactorial process involving B cell lymphoma ...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2014.10.004

    authors： Crotty S

    更新日期：2014-10-16 00:00:00

  • Not All Lymph Nodes Are Created Equal.

    abstract：:Appropriate priming of tolerogenic or effector immune responses is crucial for intestinal homeostasis. Recently in Nature, Esterházy et al. (2019) reveal how compartmentalization of lymphatic drainage to functionally distinct lymph nodes facilitates the simultaneous induction of tolerogenic and effector responses. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2019.06.018

    authors： Thomson CA,McCoy KD

    更新日期：2019-07-16 00:00:00

  • One bug or another: promiscuous T cells form lifelong memory.

    abstract：:As humans age, their T cell repertoire becomes dominated by cells exhibiting "memory" characteristics. In this issue of Immunity, Su et al. (2013) demonstrate that a large percentage of virus-specific CD4(+) T cells also exhibit a memory phenotype in unexposed adults. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2013.02.002

    authors： Nolz JC,Harty JT

    更新日期：2013-02-21 00:00:00

  • How do adjuvants work? Important considerations for new generation adjuvants.

    abstract：:In this Commentary, McKee et al. highlight the properties of extrinsic vaccine adjuvants that must be considered to achieve the most protective immune response, as occurs naturally with many intrinsic pathogen-derived adjuvants. ...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2007.11.003

    authors： McKee AS,Munks MW,Marrack P

    更新日期：2007-11-01 00:00:00

  • Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches.

    abstract：:In the bone marrow, the special microenvironment niches nurture a pool of hematopoietic stem cells (HSCs). Many HSCs reside near the vasculature, but the molecular regulatory mechanism of niches for HSC maintenance remains unclear. Here we showed that the induced deletion of CXCR4, a receptor for CXC chemokine ligand ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2006.10.016

    authors： Sugiyama T,Kohara H,Noda M,Nagasawa T

    更新日期：2006-12-01 00:00:00

  • Treg cells and CTLA-4: the ball and chain of the germinal center response.

    abstract：:The mechanism by which regulatory T cells control the germinal center response is unknown. In this issue of Immunity, Wing et al. (2014) and Sage et al. (2014) demonstrate that CTLA-4 is a critical effector molecule used by regulatory T cells to control the germinal center. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2014.12.009

    authors： Linterman MA,Denton AE

    更新日期：2014-12-18 00:00:00

  • Toll-like receptor 9, what o'clock is it?

    abstract：:In this issue of Immunity, Silver et al. (2012) provide evidence that murine Toll-like receptor 9 (TLR9) expression and function in innate and adaptive immunity is controlled by the circadian cycle. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2012.02.003

    authors： Obermann HL,Bauer S

    更新日期：2012-02-24 00:00:00

  • The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans.

    abstract：:B cell subsets expressing the transcription factor T-bet are associated with humoral immune responses and autoimmunity. Here, we examined the anatomic distribution, clonal relationships, and functional properties of T-bet+ and T-bet- memory B cells (MBCs) in the context of the influenza-specific immune response. In mi...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2020.03.020

    authors： Johnson JL,Rosenthal RL,Knox JJ,Myles A,Naradikian MS,Madej J,Kostiv M,Rosenfeld AM,Meng W,Christensen SR,Hensley SE,Yewdell J,Canaday DH,Zhu J,McDermott AB,Dori Y,Itkin M,Wherry EJ,Pardi N,Weissman D,Naji A,Pra

    更新日期：2020-05-19 00:00:00

  • A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation.

    abstract：:The epidermal growth factor receptor ligand Amphiregulin has a well-documented role in the restoration of tissue homeostasis after injury; however, the mechanism by which Amphiregulin contributes to wound repair remains unknown. Here we show that Amphiregulin functioned by releasing bioactive transforming growth facto...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2019.01.008

    authors： Minutti CM,Modak RV,Macdonald F,Li F,Smyth DJ,Dorward DA,Blair N,Husovsky C,Muir A,Giampazolias E,Dobie R,Maizels RM,Kendall TJ,Griggs DW,Kopf M,Henderson NC,Zaiss DM

    更新日期：2019-03-19 00:00:00

  • Alternative activation of macrophages: mechanism and functions.

    abstract：:The concept of an alternative pathway of macrophage activation has stimulated interest in its definition, mechanism, and functional significance in homeostasis and disease. We assess recent research in this field, argue for a restricted definition, and explore pathways by which the T helper 2 (Th2) cell cytokines inte...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2010.05.007

    authors： Gordon S,Martinez FO

    更新日期：2010-05-28 00:00:00