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We Can Still Be Friends: IFN-γ Breaks Up Macrophage Enhancers.

Abstract：

:Interferon (IFN)-γ can prime macrophages for inflammatory responses by several mechanisms, including enhancer establishment and gene activation. In this issue of Immunity, Kang et al. (2017) provide insight into the mechanisms of IFN-γ-mediated gene repression as they show that IFN-γ promotes the disassembly of select active enhancers by interfering with enhancer-binding transcription factor MAF.

journal_name

Immunity

journal_title

Immunity

authors

Novakovic B,Wang C,Logie C

doi

10.1016/j.immuni.2017.08.002

subject

Has Abstract

pub_date

2017-08-15 00:00:00

pages

209-211

issue

2

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(17)30337-0

journal_volume

47

pub_type

评论,杂志文章

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