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The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons.

Abstract：

:The cationic polysaccharide chitosan is an attractive candidate adjuvant capable of driving potent cell-mediated immunity, but the mechanism by which it acts is not clear. We show that chitosan promotes dendritic cell maturation by inducing type I interferons (IFNs) and enhances antigen-specific T helper 1 (Th1) responses in a type I IFN receptor-dependent manner. The induction of type I IFNs, IFN-stimulated genes and dendritic cell maturation by chitosan required the cytoplasmic DNA sensor cGAS and STING, implicating this pathway in dendritic cell activation. Additionally, this process was dependent on mitochondrial reactive oxygen species and the presence of cytoplasmic DNA. Chitosan-mediated enhancement of antigen specific Th1 and immunoglobulin G2c responses following vaccination was dependent on both cGAS and STING. These findings demonstrate that a cationic polymer can engage the STING-cGAS pathway to trigger innate and adaptive immune responses.

journal_name

Immunity

journal_title

Immunity

authors

Carroll EC,Jin L,Mori A,Muñoz-Wolf N,Oleszycka E,Moran HBT,Mansouri S,McEntee CP,Lambe E,Agger EM,Andersen P,Cunningham C,Hertzog P,Fitzgerald KA,Bowie AG,Lavelle EC

doi

10.1016/j.immuni.2016.02.004

subject

Has Abstract

pub_date

2016-03-15 00:00:00

pages

597-608

issue

3

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(16)30019-X

journal_volume

44

pub_type

杂志文章

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