Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation.

abstract：:Higher- or lower-affinity germinal center (GC) B cells are directed either to plasma cell or GC recycling, respectively; however, how commitment to the plasma cell fate takes place is unclear. We found that a population of light zone (LZ) GC cells, Bcl6loCD69hi expressing a transcription factor IRF4 and higher-affinit...

journal_title：Immunity

authors： Ise W,Fujii K,Shiroguchi K,Ito A,Kometani K,Takeda K,Kawakami E,Yamashita K,Suzuki K,Okada T,Kurosaki T

更新日期：2018-04-17 00:00:00

abstract：:The intestinal microbiota shapes and directs immune development locally and systemically, but little is known about whether commensal microbes in the stomach can impact their immunological microenvironment. Here, we report that group 2 innate lymphoid cells (ILC2s) were the predominant ILC subset in the stomach and sh...

journal_title：Immunity

authors： Satoh-Takayama N,Kato T,Motomura Y,Kageyama T,Taguchi-Atarashi N,Kinoshita-Daitoku R,Kuroda E,Di Santo JP,Mimuro H,Moro K,Ohno H

更新日期：2020-04-14 00:00:00

abstract：:Latent and activated forms of Stat1 and Stat6 have been expressed and purified, enabling biochemical experiments relating to their functional activities. Stat1 bound to a phosphotyrosine peptide derived from the IFN gamma receptor with a KD of 50 nM, whereas Stat6 bound to an IL-4 receptor peptide with a KD of 300 nM....

journal_title：Immunity

authors： Schindler U,Wu P,Rothe M,Brasseur M,McKnight SL

更新日期：1995-06-01 00:00:00

abstract：:CD8 T cells persist at high frequencies in peripheral organs after resolution of an immune response, and their presence in the periphery is important for resistance to secondary challenge. We show here that LCMV-specific T cells in peripheral tissue (peritoneal cavity, lung, fat pads) reacted much less with the apopto...

journal_title：Immunity

authors： Wang XZ,Stepp SE,Brehm MA,Chen HD,Selin LK,Welsh RM

更新日期：2003-05-01 00:00:00

abstract：:Transcriptional regulation of the Nos2 gene encoding inducible nitric oxide synthase (iNOS) requires type I interferon (IFN-I) signaling and additional signals emanating from pattern recognition receptors. Here we showed sequential and cooperative contributions of the transcription factors ISGF3 (a complex containing ...

journal_title：Immunity

authors： Farlik M,Reutterer B,Schindler C,Greten F,Vogl C,Müller M,Decker T

更新日期：2010-07-23 00:00:00

abstract：:Neonatal female mice injected with the self ZP3 peptide are not tolerant to the peptide; they develop autoimmune ovarian disease (AOD) and autoantibody response 5 weeks later. ZP3 challenge leads to severe AOD and ZP3-specific T cell and antibody responses. In contrast, neonatal tolerance to foreign ZP3 peptide is est...

journal_title：Immunity

authors： Garza KM,Griggs ND,Tung KS

更新日期：1997-01-01 00:00:00

abstract：:After antigen-driven expansion, the majority of T cells involved in an immune response die rapidly by apoptosis dependent on the Bcl-2 related proteins, Bim and Bax or Bak. The details of how these proteins are activated and interact are still unclear. The crystal structure of mouse Bcl-x(L) bound to a long helical fr...

journal_title：Immunity

authors： Liu X,Dai S,Zhu Y,Marrack P,Kappler JW

更新日期：2003-09-01 00:00:00

abstract：:During signal transduction through the B cell antigen receptor (BCR), several signaling elements are brought together by the adaptor protein SLP-65. We have investigated the role of SLP-65 in B cell maturation and function in mice deficient for SLP-65. While the mice are viable, B cell development is affected at sever...

journal_title：Immunity

authors： Jumaa H,Wollscheid B,Mitterer M,Wienands J,Reth M,Nielsen PJ

更新日期：1999-11-01 00:00:00

abstract：:Vgamma9Vdelta2 T lymphocytes, a major gammadelta T lymphocyte subset in humans, display cytolytic activity against various tumor cells upon recognition of yet uncharacterized structures. Here, we show that an entity related to the mitochondrial F1-ATPase is expressed on tumor cell surface and promotes tumor recognitio...

journal_title：Immunity

authors： Scotet E,Martinez LO,Grant E,Barbaras R,Jenö P,Guiraud M,Monsarrat B,Saulquin X,Maillet S,Estève JP,Lopez F,Perret B,Collet X,Bonneville M,Champagne E

更新日期：2005-01-01 00:00:00

abstract：:The transcriptional repressor Id2 is constitutively expressed in all innate lymphoid cells (ILCs) and is required for their development. In this issue of Immunity, Mowel et al. (2017) demonstrate that Id2 expression is regulated by a cell type-specific cis-regulatory element in group 1 ILCs that is demarcated by a lon...

journal_title：Immunity

authors： Sun M,Kee BL

更新日期：2017-09-19 00:00:00

abstract：:Mycobacterium tuberculosis infection in humans triggers formation of granulomas, which are tightly organized immune cell aggregates that are the central structure of tuberculosis. Infected and uninfected macrophages interdigitate, assuming an altered, flattened appearance. Although pathologists have described these ch...

journal_title：Immunity

authors： Cronan MR,Beerman RW,Rosenberg AF,Saelens JW,Johnson MG,Oehlers SH,Sisk DM,Jurcic Smith KL,Medvitz NA,Miller SE,Trinh LA,Fraser SE,Madden JF,Turner J,Stout JE,Lee S,Tobin DM

更新日期：2016-10-18 00:00:00

abstract：:Elevated inflammation in the female genital tract is associated with increased HIV risk. Cervicovaginal bacteria modulate genital inflammation; however, their role in HIV susceptibility has not been elucidated. In a prospective cohort of young, healthy South African women, we found that individuals with diverse genita...

journal_title：Immunity

authors： Gosmann C,Anahtar MN,Handley SA,Farcasanu M,Abu-Ali G,Bowman BA,Padavattan N,Desai C,Droit L,Moodley A,Dong M,Chen Y,Ismail N,Ndung'u T,Ghebremichael MS,Wesemann DR,Mitchell C,Dong KL,Huttenhower C,Walker BD,Virgi

更新日期：2017-01-17 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1)-infected corneas can develop a blinding immunoinflammatory condition called herpes stromal keratitis (HSK), which involves the loss of corneal sensitivity due to retraction of sensory nerves and subsequent hyperinnervation with sympathetic nerves. Increased concentrations of the cyt...

journal_title：Immunity

authors： Yun H,Yee MB,Lathrop KL,Kinchington PR,Hendricks RL,St Leger AJ

更新日期：2020-11-17 00:00:00

abstract：:Stat6 is critical for IL-4-mediated Th2 cell development, but its molecular mechanism remains unclear. Here we constructed Stat6:ER, a Stat6-estrogen receptor fusion protein that can be activated by 4-hydroxy-tamoxifen, independently of IL-4 and endogenous Stat6. Retrovirus-mediated introduction of Stat6:ER into devel...

journal_title：Immunity

authors： Kurata H,Lee HJ,O'Garra A,Arai N

更新日期：1999-12-01 00:00:00

abstract：:Uric acid (UA) crystals are a potent stimulator of inflammation, but how they activate immune cells is not known. In this issue of Immunity, Ng et al. (2008) provide evidence suggesting that UA activates the Syk kinase via membrane cholesterol. ...

journal_title：Immunity

authors： DeFranco AL

更新日期：2008-11-14 00:00:00

abstract：:Precise intrathymic cell migration is important for thymocyte maturation and organ architecture. The orchestration of thymocyte trafficking, however, is not well understood at a molecular level. Here, we described highly regulated plexinD1 expression on CD4+CD8+ double positive (DP) thymocytes. PlexinD1 expression was...

journal_title：Immunity

authors： Choi YI,Duke-Cohan JS,Ahmed WB,Handley MA,Mann F,Epstein JA,Clayton LK,Reinherz EL

更新日期：2008-12-19 00:00:00

abstract：:Adaptive immune responses begin when naive CD4(+) T cells engage peptide+major histocompatibility complex class II and co-stimulatory molecules on antigen-presenting cells (APCs). Notch signaling can influence effector functions in differentiated CD4(+) T helper and T regulatory cells. Whether and how ligand-induced N...

journal_title：Immunity

authors： Laky K,Evans S,Perez-Diez A,Fowlkes BJ

更新日期：2015-01-20 00:00:00

abstract：:Mutations in the NALP3/CIAS1/cryopyrin gene are linked to three autoinflammatory disorders: Muckle-Wells syndrome, familial cold autoinflammatory syndrome, and chronic infantile neurologic cutaneous and articular syndrome. NALP3, with the adaptor molecule ASC, has been proposed to form a caspase-1-activating "inflamma...

journal_title：Immunity

authors： Sutterwala FS,Ogura Y,Szczepanik M,Lara-Tejero M,Lichtenberger GS,Grant EP,Bertin J,Coyle AJ,Galán JE,Askenase PW,Flavell RA

更新日期：2006-03-01 00:00:00

abstract：:Direct and indirect cytopathic mechanisms have been proposed to account for the loss of CD4+ T cells after infection with human immunodeficiency virus type 1 (HIV-1). We report here that HIV-1 infection of the human thymus in vivo results in thymocyte depletion by at least two different mechanisms. Thymocytes within m...

journal_title：Immunity

authors： Su L,Kaneshima H,Bonyhadi M,Salimi S,Kraft D,Rabin L,McCune JM

更新日期：1995-01-01 00:00:00

abstract：:Memory T cells provide long-lasting protective immunity, and distinct subpopulations of memory T cells drive chronic inflammatory diseases such as asthma. Asthma is a chronic allergic inflammatory disease with airway remodeling including fibrotic changes. The immunological mechanisms that induce airway fibrotic change...

journal_title：Immunity

authors： Morimoto Y,Hirahara K,Kiuchi M,Wada T,Ichikawa T,Kanno T,Okano M,Kokubo K,Onodera A,Sakurai D,Okamoto Y,Nakayama T

更新日期：2018-07-17 00:00:00

abstract：:We previously reported that the mice deficient for SPA-1, a Rap1 GTPase-activating protein, developed hematopoietic stem cell disorders. Here, we demonstrate that SPA-1(-/-) mice show an age-dependent increase in B220(high) B1a cells producing anti-dsDNA antibody and lupus-like nephritis. SPA-1(-/-) peritoneal B1 cell...

journal_title：Immunity

authors： Ishida D,Su L,Tamura A,Katayama Y,Kawai Y,Wang SF,Taniwaki M,Hamazaki Y,Hattori M,Minato N

更新日期：2006-04-01 00:00:00

abstract：:The concept of an alternative pathway of macrophage activation has stimulated interest in its definition, mechanism, and functional significance in homeostasis and disease. We assess recent research in this field, argue for a restricted definition, and explore pathways by which the T helper 2 (Th2) cell cytokines inte...

journal_title：Immunity

authors： Gordon S,Martinez FO

更新日期：2010-05-28 00:00:00

abstract：:Follicular helper T (Tfh) cells are specialized providers of T cell help to B cells, and are essential for germinal center formation, affinity maturation, and the development of most high-affinity antibodies and memory B cells. Tfh cell differentiation is a multistage, multifactorial process involving B cell lymphoma ...

journal_title：Immunity

authors： Crotty S

更新日期：2014-10-16 00:00:00

abstract：:Depending on the tissue microenvironment, T cells can differentiate into highly diverse subsets expressing unique trafficking receptors and cytokines. Studies of human lymphocytes have primarily focused on a limited number of parameters in blood, representing an incomplete view of the human immune system. Here, we hav...

journal_title：Immunity

authors： Wong MT,Ong DE,Lim FS,Teng KW,McGovern N,Narayanan S,Ho WQ,Cerny D,Tan HK,Anicete R,Tan BK,Lim TK,Chan CY,Cheow PC,Lee SY,Takano A,Tan EH,Tam JK,Tan EY,Chan JK,Fink K,Bertoletti A,Ginhoux F,Curotto de Lafail

更新日期：2016-08-16 00:00:00

abstract：:Notch proteins are cell surface receptors that mediate developmental cell specification events. To explore the function of murine Notch1, an essential portion of the gene was flanked with loxP sites and inactivation induced via interferon-regulated Cre recombinase. Mice with a neonatally induced loss of Notch1 functio...

journal_title：Immunity

authors： Radtke F,Wilson A,Stark G,Bauer M,van Meerwijk J,MacDonald HR,Aguet M

更新日期：1999-05-01 00:00:00

abstract：:The decline in CD4+ T cell function with aging contributes to reduced vaccine efficacy. In this commentary, we discuss the factors leading to age-related changes in T cell function and propose how they may be overcome to enhance vaccine efficacy for the elderly. ...

journal_title：Immunity

authors： Haynes L,Swain SL

更新日期：2006-06-01 00:00:00

abstract：:Aryl hydrocarbon receptor (Ahr) is crucial for the maintenance and function of group 3 innate lymphoid cells (ILCs), which are important in gut immunity. Because Ahr promotes T helper 17 (Th17) cell differentiation in vitro, it is reasonable to expect that Ahr would enhance Th17 cells in vivo. Instead, we show that Ah...

journal_title：Immunity

authors： Qiu J,Guo X,Chen ZM,He L,Sonnenberg GF,Artis D,Fu YX,Zhou L

更新日期：2013-08-22 00:00:00

abstract：:Null mutations that cripple T cell receptor (TCR) signaling explain rare primary immunodeficiencies, but it is not understood why more common polymorphisms that lead to subtle TCR signaling defects are paradoxically associated with autoimmunity. Here we analyzed how a series of Zap70 variants with step-wise decreases ...

journal_title：Immunity

authors： Siggs OM,Miosge LA,Yates AL,Kucharska EM,Sheahan D,Brdicka T,Weiss A,Liston A,Goodnow CC

更新日期：2007-12-01 00:00:00

abstract：:The tumor necrosis factor receptor superfamily member HVEM is one of the most frequently mutated surface proteins in germinal center (GC)-derived B cell lymphomas. We found that HVEM deficiency increased B cell competitiveness during pre-GC and GC responses. The immunoglobulin (Ig) superfamily protein BTLA regulated H...

journal_title：Immunity

authors： Mintz MA,Felce JH,Chou MY,Mayya V,Xu Y,Shui JW,An J,Li Z,Marson A,Okada T,Ware CF,Kronenberg M,Dustin ML,Cyster JG

更新日期：2019-08-20 00:00:00

abstract：:Polyreactivity is the ability of a single antibody to bind to multiple molecularly distinct antigens and is a common feature of antibodies induced upon pathogen exposure. However, little is known about the role of polyreactivity during anti-influenza virus antibody responses. By analyzing more than 500 monoclonal anti...

journal_title：Immunity

authors： Guthmiller JJ,Lan LY,Fernández-Quintero ML,Han J,Utset HA,Bitar DJ,Hamel NJ,Stovicek O,Li L,Tepora M,Henry C,Neu KE,Dugan HL,Borowska MT,Chen YQ,Liu STH,Stamper CT,Zheng NY,Huang M,Palm AE,García-Sastre A,Nachba

更新日期：2020-12-15 00:00:00