Abstract:
:Memory T cells provide long-lasting protective immunity, and distinct subpopulations of memory T cells drive chronic inflammatory diseases such as asthma. Asthma is a chronic allergic inflammatory disease with airway remodeling including fibrotic changes. The immunological mechanisms that induce airway fibrotic changes remain unknown. We found that interleukin-33 (IL-33) enhanced amphiregulin production by the IL-33 receptor, ST2hi memory T helper 2 (Th2) cells. Amphiregulin-epidermal growth factor receptor (EGFR)-mediated signaling directly reprogramed eosinophils to an inflammatory state with enhanced production of osteopontin, a key profibrotic immunomodulatory protein. IL-5-producing memory Th2 cells and amphiregulin-producing memory Th2 cells appeared to cooperate to establish lung fibrosis. The analysis of polyps from patients with eosinophilic chronic rhinosinusitis revealed fibrosis with accumulation of amphiregulin-producing CRTH2hiCD161hiCD45RO+CD4+ Th2 cells and osteopontin-producing eosinophils. Thus, the IL-33-amphiregulin-osteopontin axis directs fibrotic responses in eosinophilic airway inflammation and is a potential target for the treatment of fibrosis induced by chronic allergic disorders.
journal_name
Immunityjournal_title
Immunityauthors
Morimoto Y,Hirahara K,Kiuchi M,Wada T,Ichikawa T,Kanno T,Okano M,Kokubo K,Onodera A,Sakurai D,Okamoto Y,Nakayama Tdoi
10.1016/j.immuni.2018.04.023subject
Has Abstractpub_date
2018-07-17 00:00:00pages
134-150.e6issue
1eissn
1074-7613issn
1097-4180pii
S1074-7613(18)30192-4journal_volume
49pub_type
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