ILC-poiesis: Making Tissue ILCs from Blood.

abstract：:In this issue of Immunity, Schweighoffer et al. (2013) report that full BAFF responsiveness in B cells requires the tyrosine kinase Syk and that BAFF may co-opt components of the B cell receptor in transmitting its survival signal. ...

journal_title：Immunity

authors： Infantino S,Tarlinton DM

更新日期：2013-03-21 00:00:00

abstract：:Description of macrophage activation is currently contentious and confusing. Like the biblical Tower of Babel, macrophage activation encompasses a panoply of descriptors used in different ways. The lack of consensus on how to define macrophage activation in experiments in vitro and in vivo impedes progress in multiple...

journal_title：Immunity

authors： Murray PJ,Allen JE,Biswas SK,Fisher EA,Gilroy DW,Goerdt S,Gordon S,Hamilton JA,Ivashkiv LB,Lawrence T,Locati M,Mantovani A,Martinez FO,Mege JL,Mosser DM,Natoli G,Saeij JP,Schultze JL,Shirey KA,Sica A,Suttles J,U

更新日期：2014-07-17 00:00:00

abstract：:Class-switch recombination (CSR) is a DNA recombination process that replaces the immunoglobulin (Ig) constant region for the isotype that can best protect against the pathogen. Dysregulation of CSR can cause self-reactive BCRs and B cell lymphomas; understanding the timing and location of CSR is therefore important. ...

journal_title：Immunity

authors： Roco JA,Mesin L,Binder SC,Nefzger C,Gonzalez-Figueroa P,Canete PF,Ellyard J,Shen Q,Robert PA,Cappello J,Vohra H,Zhang Y,Nowosad CR,Schiepers A,Corcoran LM,Toellner KM,Polo JM,Meyer-Hermann M,Victora GD,Vinuesa CG

更新日期：2019-08-20 00:00:00

abstract：:The ability of human CD1b molecules to present nonpeptide antigens is suggested by the T cell recognition of microbial lipids and lipoglycans in the presence of CD1b-expressing antigen-presenting cells. We demonstrate the high-affinity interaction of CD1b molecules with the acyl side chains of known T cell antigens, l...

journal_title：Immunity

authors： Ernst WA,Maher J,Cho S,Niazi KR,Chatterjee D,Moody DB,Besra GS,Watanabe Y,Jensen PE,Porcelli SA,Kronenberg M,Modlin RL

更新日期：1998-03-01 00:00:00

abstract：:The interferon-producing plasmacytoid dendritic cells (pDCs) share common progenitors with antigen-presenting classical dendritic cells (cDCs), yet they possess distinct morphology and molecular features resembling those of lymphocytes. It is unclear whether the unique cell fate of pDCs is actively maintained in the s...

journal_title：Immunity

authors： Ghosh HS,Cisse B,Bunin A,Lewis KL,Reizis B

更新日期：2010-12-14 00:00:00

abstract：:The Notch2 ligand DL1 is required for marginal zone B cell development. In this issue of Immunity, Tan et al. (2009) show that modification of Notch2 by Fringe enzymes is critical to maturing B cells for accessing DL1 on vascular endothelial cells. ...

journal_title：Immunity

authors： Allman D,Calamito M

更新日期：2009-02-20 00:00:00

abstract：:Activation of the transcription factor NF-kappa B and pre-T cell receptor (pre-TCR) expression is tightly correlated during thymocyte development. Inhibition of NF-kappa B in isolated thymocytes in vitro results in spontaneous apoptosis of cells expressing the pre-TCR, whereas inhibition of NF-kappa B in transgenic mi...

journal_title：Immunity

authors： Voll RE,Jimi E,Phillips RJ,Barber DF,Rincon M,Hayday AC,Flavell RA,Ghosh S

更新日期：2000-11-01 00:00:00

abstract：:While the majority of purified pluripotential hematopoietic stem cells (PHSC) express c-Kit, the receptor for steel factor, we have phenotypically and functionally separated a distinct class of PHSC that does not express c-Kit. In contrast to c-Kit-positive (c-Kit(pos)) PHSC, the c-Kit-negative (c-Kit(neg)) PHSC do no...

journal_title：Immunity

authors： Ortiz M,Wine JW,Lohrey N,Ruscetti FW,Spence SE,Keller JR

更新日期：1999-02-01 00:00:00

abstract：:Disease tolerance describes the ability of an infected host to limit disease severity without negatively impacting the causative pathogen. Bessede et al. (2014) show that the aryl hydrocarbon receptor is an essential component of disease tolerance during bacterial infection in mice. ...

journal_title：Immunity

authors： Soares MP

更新日期：2014-08-21 00:00:00

abstract：:TRAIL is a newly identified cytokine belonging to the large tumor necrosis factor (TNF) family. TRAIL is a novel molecule inducing apoptosis in a wide variety of tumor cells but not in normal cells. To help in elucidating its biological roles and designing mutants with improved therapeutic potential, we have determine...

journal_title：Immunity

authors： Cha SS,Kim MS,Choi YH,Sung BJ,Shin NK,Shin HC,Sung YC,Oh BH

更新日期：1999-08-01 00:00:00

abstract：:CD70 and CD27 are costimulatory molecules that provide essential signals for the expansion and differentiation of CD8(+) T cells. Here, we show that CD27-driven costimulation lowered the threshold of T cell receptor activation on CD8(+) T cells and enabled responses against low-affinity antigens. Using influenza infec...

journal_title：Immunity

authors： van Gisbergen KP,Klarenbeek PL,Kragten NA,Unger PP,Nieuwenhuis MB,Wensveen FM,ten Brinke A,Tak PP,Eldering E,Nolte MA,van Lier RA

更新日期：2011-07-22 00:00:00

abstract：:We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified six immune subtypes-wound healing, IFN-γ dominant, inflammatory, lymphocyte depleted, immunologically quiet, and TGF-β dominant-character...

journal_title：Immunity

authors： Thorsson V,Gibbs DL,Brown SD,Wolf D,Bortone DS,Ou Yang TH,Porta-Pardo E,Gao GF,Plaisier CL,Eddy JA,Ziv E,Culhane AC,Paull EO,Sivakumar IKA,Gentles AJ,Malhotra R,Farshidfar F,Colaprico A,Parker JS,Mose LE,Vo NS,L

更新日期：2018-04-17 00:00:00

abstract：:Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as such are vitally important for humoral immunity. The study of GC biology has undergone a renaissance in the past 10 years, with a succession of findings that have transformed our understanding of the cellular dynamics of aff...

journal_title：Immunity

authors： Mesin L,Ersching J,Victora GD

更新日期：2016-09-20 00:00:00

abstract：:The immunological synapse is characterized by the reorganization of membrane proteins at the immunological synapse. Active cytoskeletal mechanisms are involved in recruiting the TCR, accessory molecules, and the integrin LFA-1 to the contact area. Other molecules like CD43 are excluded from the contact area, but the m...

journal_title：Immunity

authors： Shaw AS

更新日期：2001-11-01 00:00:00

abstract：:La Crosse virus (LACV), a zoonotic Bunyavirus, is a major cause of pediatric viral encephalitis in the United States. A hallmark of neurological diseases caused by LACV and other encephalitic viruses is the induction of neuronal cell death. Innate immune responses have been implicated in neuronal damage, but no mechan...

journal_title：Immunity

authors： Mukherjee P,Woods TA,Moore RA,Peterson KE

更新日期：2013-04-18 00:00:00

abstract：:Reorganization of the actin cytoskeleton requires nucleating factors, which initiate actin fiber formation. In this issue of Immunity, the functions of two classes of actin nucleators are examined in T lymphocytes, giving insight into the regulation of T cell polarity (Gomez et al., 2007). ...

journal_title：Immunity

authors： Schwartzberg PL

更新日期：2007-02-01 00:00:00

abstract：:How is the amoeboid movement of lymphocytes in secondary lymphoid organs orchestrated? In this issue of Immunity, Bajénoff et al. (2006) demonstrate that stromal cell networks serve as guidance structures that direct and limit the migration of B and T cells in lymph nodes. ...

journal_title：Immunity

authors： Mempel TR,Junt T,von Andrian UH

更新日期：2006-12-01 00:00:00

abstract：:Gene-expression profiling has become a mainstay in immunology, but subtle changes in gene networks related to biological processes are hard to discern when comparing various datasets. For instance, conservation of the transcriptional response to sepsis in mouse models and human disease remains controversial. To improv...

journal_title：Immunity

authors： Godec J,Tan Y,Liberzon A,Tamayo P,Bhattacharya S,Butte AJ,Mesirov JP,Haining WN

更新日期：2016-01-19 00:00:00

abstract：:Cytokine regulation of B cell development was analyzed using interleukin-2 (IL-2)-induced transcription of the J chain gene as a model system. A nuclear target of the IL-2 signal was identified as the Pax5 transcription factor, BSAP, which recognizes a negative regulatory motif in the J chain promoter. Functional assa...

journal_title：Immunity

authors： Rinkenberger JL,Wallin JJ,Johnson KW,Koshland ME

更新日期：1996-10-01 00:00:00

abstract：:Little is known about the functional differences between the human skin myeloid dendritic cell (DC) subsets, epidermal CD207(+) Langerhans cells (LCs) and dermal CD14(+) DCs. We showed that CD14(+) DCs primed CD4(+) T cells into cells that induce naive B cells to switch isotype and become plasma cells. In contrast, LC...

journal_title：Immunity

authors： Klechevsky E,Morita R,Liu M,Cao Y,Coquery S,Thompson-Snipes L,Briere F,Chaussabel D,Zurawski G,Palucka AK,Reiter Y,Banchereau J,Ueno H

更新日期：2008-09-19 00:00:00

abstract：:Successful organ transplantation requires an optimal innate immune response to avoid tissue injury. In this issue of Immunity, Braza et al. (2018) inhibit pro-inflammatory activation of infiltrating graft macrophages using nanotechnology tools to promote immune tolerance, leading to long-term transplant acceptance in ...

journal_title：Immunity

authors： Pascual-Gil S,Epelman S

更新日期：2018-11-20 00:00:00

abstract：:Invariant chain (Ii)-negative mice exhibit defects in MHC class II assembly and transport that results in reduced levels of surface class II, altered antigen presentation, and inefficient positive selection of CD4+ T cells. Many CD4+ T cells that do mature in Ii-negative mice express a cell surface phenotype consisten...

journal_title：Immunity

authors： Naujokas MF,Arneson LS,Fineschi B,Peterson ME,Sitterding S,Hammond AT,Reilly C,Lo D,Miller J

更新日期：1995-09-01 00:00:00

abstract：:The current structural model of the B cell antigen receptor (BCR) describes it as a symmetric protein complex in which one membrane-bound immunoglobulin molecule (mIg) is noncovalently bound on each side by an Ig-alpha/Ig-beta heterodimer. Using peptide-tagged Ig-alpha proteins, blue native polyacrylamide gel electrop...

journal_title：Immunity

authors： Schamel WW,Reth M

更新日期：2000-07-01 00:00:00

abstract：:SARS-CoV-2, the causal agent of COVID-19, first emerged in late 2019 in China. It has since infected more than 870,000 individuals and caused more than 43,000 deaths globally. Here, we discuss therapeutic and prophylactic interventions for SARS-CoV-2 with a focus on vaccine development and its challenges. Vaccines are...

journal_title：Immunity

authors： Amanat F,Krammer F

更新日期：2020-04-14 00:00:00

abstract：:In allergic patients, small amounts of allergen activate mast cells and trigger an immune cascade that can result in anaphylactic shock. In a recent issue of Science, Choi et al. (2018) show that dendritic cells sample the lumen of blood vessels and use microvesicles to trigger mast cell degranulation and anaphylaxis....

journal_title：Immunity

authors： Sallis BF,Fiebiger E

更新日期：2018-12-18 00:00:00

abstract：:The death domain kinase RIP and the TNF receptor-associated factor 2 (TRAF2) are essential effectors in TNF signaling. To understand the mechanism by which RIP and TRAF2 regulate TNF-induced activation of the transcription factor NF-kappaB, we investigated their respective roles in TNF-R1-mediated IKK activation using...

journal_title：Immunity

authors： Devin A,Cook A,Lin Y,Rodriguez Y,Kelliher M,Liu Z

更新日期：2000-04-01 00:00:00

abstract：:Toll-like receptor-9 (TLR9) is largely responsible for discriminating self from pathogenic DNA. However, association of host DNA with autoantibodies activates TLR9, inducing the pathogenic secretion of type I interferons (IFNs) from plasmacytoid dendritic cells (pDCs). Here, we found that in response to DNA-containing...

journal_title：Immunity

authors： Henault J,Martinez J,Riggs JM,Tian J,Mehta P,Clarke L,Sasai M,Latz E,Brinkmann MM,Iwasaki A,Coyle AJ,Kolbeck R,Green DR,Sanjuan MA

更新日期：2012-12-14 00:00:00

abstract：:A unique subpopulation of spleen dendritic cells (DCs) that express the CD8 surface marker efficiently present phagocytosed antigens to CD8(+) T lymphocytes in a process called "crosspresentation," which initiates cytotoxic immune responses. We now show that the small GTPase Rac2 plays a critical role in antigen cross...

journal_title：Immunity

authors： Savina A,Peres A,Cebrian I,Carmo N,Moita C,Hacohen N,Moita LF,Amigorena S

更新日期：2009-04-17 00:00:00

abstract：:Crosspresentation of exogenous antigens (Ags) to CD8(+) T cells by dendritic cells generally requires their entry into the cytosol. Here we show that both soluble and phagocytosed extracellular Ags accessed the cytosol via molecular components required for endoplasmic reticulum (ER)-associated degradation (ERAD). Exog...

journal_title：Immunity

authors： Ackerman AL,Giodini A,Cresswell P

更新日期：2006-10-01 00:00:00

abstract：:Elevated inflammation in the female genital tract is associated with increased HIV risk. Cervicovaginal bacteria modulate genital inflammation; however, their role in HIV susceptibility has not been elucidated. In a prospective cohort of young, healthy South African women, we found that individuals with diverse genita...

journal_title：Immunity

authors： Gosmann C,Anahtar MN,Handley SA,Farcasanu M,Abu-Ali G,Bowman BA,Padavattan N,Desai C,Droit L,Moodley A,Dong M,Chen Y,Ismail N,Ndung'u T,Ghebremichael MS,Wesemann DR,Mitchell C,Dong KL,Huttenhower C,Walker BD,Virgi

更新日期：2017-01-17 00:00:00