Instructing B cell fates on the fringe.

abstract：:Crosspresentation of exogenous antigens (Ags) to CD8(+) T cells by dendritic cells generally requires their entry into the cytosol. Here we show that both soluble and phagocytosed extracellular Ags accessed the cytosol via molecular components required for endoplasmic reticulum (ER)-associated degradation (ERAD). Exog...

journal_title：Immunity

authors： Ackerman AL,Giodini A,Cresswell P

更新日期：2006-10-01 00:00:00

abstract：:Aryl hydrocarbon receptor (Ahr) is crucial for the maintenance and function of group 3 innate lymphoid cells (ILCs), which are important in gut immunity. Because Ahr promotes T helper 17 (Th17) cell differentiation in vitro, it is reasonable to expect that Ahr would enhance Th17 cells in vivo. Instead, we show that Ah...

journal_title：Immunity

authors： Qiu J,Guo X,Chen ZM,He L,Sonnenberg GF,Artis D,Fu YX,Zhou L

更新日期：2013-08-22 00:00:00

abstract：:We have investigated the lymphohematopoietic potentials of endothelial cells (EC) and hematopoietic cells (HPC) sorted from embryos. Expression of VE-cadherin, CD45, and Ter119 was used to distinguish EC (VE-cadherin+CD45-Ter119-) from HPC (VE-cadherin-CD45+). Thus defined, EC population takes up acetylated LDL and co...

journal_title：Immunity

authors： Nishikawa SI,Nishikawa S,Kawamoto H,Yoshida H,Kizumoto M,Kataoka H,Katsura Y

更新日期：1998-06-01 00:00:00

abstract：:The classical model of hematopoiesis established in the mouse postulates that lymphoid cells originate from a founder population of common lymphoid progenitors. Here, using a modeling approach in humanized mice, we showed that human lymphoid development stemmed from distinct populations of CD127- and CD127+ early lymp...

journal_title：Immunity

authors： Alhaj Hussen K,Vu Manh TP,Guimiot F,Nelson E,Chabaane E,Delord M,Barbier M,Berthault C,Dulphy N,Alberdi AJ,Burlen-Defranoux O,Socié G,Bories JC,Larghero J,Vanneaux V,Verhoeyen E,Wirth T,Dalod M,Gluckman JC,Cumano A

更新日期：2017-10-17 00:00:00

abstract：:CD4 T cells are pivotal for effective immunity, yet their initial differentiation into effector subsets after infection remains poorly defined. We examined CD4 T cells specific for the immunodominant Leishmania major LACK antigen using MHC/peptide tetramers and IL-4 reporter mice. Comprising approximately 15 cells/lym...

journal_title：Immunity

authors： Stetson DB,Mohrs M,Mallet-Designe V,Teyton L,Locksley RM

更新日期：2002-08-01 00:00:00

abstract：:The mammalian gut microbiota provides essential metabolites to the host and promotes the differentiation and accumulation of extrathymically generated regulatory T (pTreg) cells. To explore the impact of these cells on intestinal microbial communities, we assessed the composition of the microbiota in pTreg cell-defici...

journal_title：Immunity

authors： Campbell C,Dikiy S,Bhattarai SK,Chinen T,Matheis F,Calafiore M,Hoyos B,Hanash A,Mucida D,Bucci V,Rudensky AY

更新日期：2018-06-19 00:00:00

abstract：:MicroRNAs have been shown to be critical for a number of aspects of immune system regulation and function. Here, we have examined the role of microRNAs in terminal B cell differentiation by analyzing Cd19-Cre(ki/+) Dicer1(fl/fl) mice. We found that in the absence of Dicer, the transitional and marginal zone (MZ) B cel...

journal_title：Immunity

authors： Belver L,de Yébenes VG,Ramiro AR

更新日期：2010-11-24 00:00:00

abstract：:NOD-like receptors (NLRs) are increasingly implicated in regulating pathogen-sensing pathways. In this issue of Immunity, Zhang et al. (2014) describe a role for NLRC3 in regulating STING and the inflammatory response to cytosolic DNA. ...

journal_title：Immunity

authors： Mangan MS,Latz E

更新日期：2014-03-20 00:00:00

abstract：:The ability of human CD1b molecules to present nonpeptide antigens is suggested by the T cell recognition of microbial lipids and lipoglycans in the presence of CD1b-expressing antigen-presenting cells. We demonstrate the high-affinity interaction of CD1b molecules with the acyl side chains of known T cell antigens, l...

journal_title：Immunity

authors： Ernst WA,Maher J,Cho S,Niazi KR,Chatterjee D,Moody DB,Besra GS,Watanabe Y,Jensen PE,Porcelli SA,Kronenberg M,Modlin RL

更新日期：1998-03-01 00:00:00

abstract：:Shigella pathogenesis has confounded researchers for years because of its narrow host selectivity and extraordinary infectious capability. In this issue of Immunity, Xu et al. (2018) identify a cunning mechanism whereby Shigella hijacks human α-defensin 5 to enhance its adhesion and subsequent invasion. ...

journal_title：Immunity

authors： Murphy AG,Maloy KJ

更新日期：2018-06-19 00:00:00

abstract：:Memory lymphocytes are characterized by their ability to exhibit a rapid response to the recall antigen, in which differential transcription is important, yet the underlying mechanism is not understood. We report here a genome-wide analysis of histone methylation on two histone H3 lysine residues (H3K4me3 and H3K27me3...

journal_title：Immunity

authors： Araki Y,Wang Z,Zang C,Wood WH 3rd,Schones D,Cui K,Roh TY,Lhotsky B,Wersto RP,Peng W,Becker KG,Zhao K,Weng NP

更新日期：2009-06-19 00:00:00

abstract：:Indoleamine 2,3 dioxygenase (IDO) catabolizes the amino acid tryptophan. IDO-expressing immunoregulatory dendritic cells (DCs) have been implicated in settings including tumors, autoimmunity, and transplant tolerance. However, the downstream molecular mechanisms by which IDO functions to regulate T cell responses rema...

journal_title：Immunity

authors： Munn DH,Sharma MD,Baban B,Harding HP,Zhang Y,Ron D,Mellor AL

更新日期：2005-05-01 00:00:00

abstract：:Three mutant immunoglobulin heavy chain (IgH) insertion mice were generated in which a targeted nonfunctional IgH passenger transgene was either devoid of promoter (pdelta) or was placed under the transcriptional control of either its own RNA polymerase II-dependent IgH promoter (pII) or a RNA polymerase I-dependent p...

journal_title：Immunity

authors： Fukita Y,Jacobs H,Rajewsky K

更新日期：1998-07-01 00:00:00

abstract：:Inflammasomes are supramolecular organizing centers that operate to drive interleukin-1 (IL-1)-dependent inflammation. Depending on context, inflammatory caspases act upstream or downstream of inflammasome assembly, serving as the principal enzymes that control activities of these organelles. In this review, we discus...

journal_title：Immunity

authors： Evavold CL,Kagan JC

更新日期：2019-10-15 00:00:00

abstract：:SARS-CoV-2, the causal agent of COVID-19, first emerged in late 2019 in China. It has since infected more than 870,000 individuals and caused more than 43,000 deaths globally. Here, we discuss therapeutic and prophylactic interventions for SARS-CoV-2 with a focus on vaccine development and its challenges. Vaccines are...

journal_title：Immunity

authors： Amanat F,Krammer F

更新日期：2020-04-14 00:00:00

abstract：:Commensal microbiota confers a goldilocks state of alertness to pathogens, yet restrains deleterious inflammation. In this issue of Immunity, Geuking et al. (2011) demonstrate that a minimal bacterial community of the Schaedler flora establishes a balance between pro- and anti-inflammatory T cells in the gut. ...

journal_title：Immunity

authors： Rudensky AY,Chervonsky AV

更新日期：2011-05-27 00:00:00

abstract：:Immunoglobulin A (IgA) is prominently secreted at mucosal surfaces and coats a fraction of the intestinal microbiota. However, the commensal bacteria bound by IgA are poorly characterized and the type of humoral immunity they elicit remains elusive. We used bacterial flow cytometry coupled with 16S rRNA gene sequencin...

journal_title：Immunity

authors： Bunker JJ,Flynn TM,Koval JC,Shaw DG,Meisel M,McDonald BD,Ishizuka IE,Dent AL,Wilson PC,Jabri B,Antonopoulos DA,Bendelac A

更新日期：2015-09-15 00:00:00

abstract：:Mutations affecting the Tec kinases Itk and Rlk decrease T cell receptor-induced Ca(2+) mobilization and Erk kinase activation and impair both positive and negative thymic selection. Itk(-/-) and Rlk(-/-)Itk(-/-) mice also have decreased CD4:8 T cell ratios, suggestive of altered CD4:8 lineage commitment. Nonetheless,...

journal_title：Immunity

authors： Broussard C,Fleischacker C,Horai R,Chetana M,Venegas AM,Sharp LL,Hedrick SM,Fowlkes BJ,Schwartzberg PL

更新日期：2006-07-01 00:00:00

abstract：:Stimulator of interferon genes (STING, also named MITA, MYPS, or ERIS) is an intracellular DNA sensor that induces type I interferon through its interaction with TANK-binding kinase 1 (TBK1). Here we found that the nucleotide-binding, leucine-rich-repeat-containing protein, NLRC3, reduced STING-dependent innate immune...

journal_title：Immunity

authors： Zhang L,Mo J,Swanson KV,Wen H,Petrucelli A,Gregory SM,Zhang Z,Schneider M,Jiang Y,Fitzgerald KA,Ouyang S,Liu ZJ,Damania B,Shu HB,Duncan JA,Ting JP

更新日期：2014-03-20 00:00:00

abstract：:The cytokine TNF is thought to play a major role in the immunopathogenesis of ulcerative colitis, and anti-TNF antibodies are considered as cornerstones of clinical therapy. Two clinical trials published in The New England Journal of Medicine now challenge this paradigm and suggest new avenues for research. ...

journal_title：Immunity

authors： Neurath MF,Chiriac MT

更新日期：2019-11-19 00:00:00

abstract：:Production of immunoglobulin heavy chain (IgH) protein feeds back to terminate further V(H) gene recombination, a phenomenon also referred to as allelic exclusion. Here we provide evidence to support the proposition that allelic exclusion is the consequence of terminating signals that activate V(H) genes for recombina...

journal_title：Immunity

authors： Chowdhury D,Sen R

更新日期：2003-02-01 00:00:00

abstract：:Secondary diversification of the B cell repertoire by immunoglobulin gene somatic hypermutation in the germinal center (GC) is essential for providing the high-affinity antibody specificities required for long-term humoral immunity. While the risk to self-tolerance posed by inadvertent generation of self-reactive GC B...

journal_title：Immunity

authors： Chan TD,Wood K,Hermes JR,Butt D,Jolly CJ,Basten A,Brink R

更新日期：2012-11-16 00:00:00

abstract：:We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified six immune subtypes-wound healing, IFN-γ dominant, inflammatory, lymphocyte depleted, immunologically quiet, and TGF-β dominant-character...

journal_title：Immunity

authors： Thorsson V,Gibbs DL,Brown SD,Wolf D,Bortone DS,Ou Yang TH,Porta-Pardo E,Gao GF,Plaisier CL,Eddy JA,Ziv E,Culhane AC,Paull EO,Sivakumar IKA,Gentles AJ,Malhotra R,Farshidfar F,Colaprico A,Parker JS,Mose LE,Vo NS,L

更新日期：2018-04-17 00:00:00

abstract：:The mechanism by which regulatory T cells control the germinal center response is unknown. In this issue of Immunity, Wing et al. (2014) and Sage et al. (2014) demonstrate that CTLA-4 is a critical effector molecule used by regulatory T cells to control the germinal center. ...

journal_title：Immunity

authors： Linterman MA,Denton AE

更新日期：2014-12-18 00:00:00

abstract：:Innate immune sensors that detect nucleic acids are attractive targets for therapeutic intervention because of their diverse roles in many disease processes. In detecting RNA and DNA from either self or non-self, nucleic acid sensors mediate the pathogenesis of many autoimmune and inflammatory conditions. Despite prom...

journal_title：Immunity

authors： McWhirter SM,Jefferies CA

更新日期：2020-07-14 00:00:00

abstract：:Mutant RAS is a major oncoprotein in human cancer and PD-L1 is a key driver of cancer immune evasion. In this issue of Immunity, Coelho et al. (2017) demonstrate that oncogenic RAS signaling promotes tumor immune escape by stabilizing PD-L1 mRNA. ...

journal_title：Immunity

authors： Glodde N,Hölzel M

更新日期：2017-12-19 00:00:00

abstract：:Recent experiments have suggested that tumor necrosis factor alpha (TNFalpha) can down-regulate islet-specific T cells and prevent the development of autoimmune diabetes. Here we demonstrate that transgenic mice expressing both TNFalpha and the Leishmania major LACK antigen in the pancreas (RIP-TNFalpha/RIP-LACK) exhi...

journal_title：Immunity

authors： McSorley SJ,Soldera S,Malherbe L,Carnaud C,Locksley RM,Flavell RA,Glaichenhaus N

更新日期：1997-09-01 00:00:00

abstract：:Activated T cells must mediate effector responses sufficiently to clear pathogens while avoiding excessive tissue damage. Here we have combined dynamic intravital microscopy with ex vivo assessments of T cell cytokine responses to generate a detailed spatiotemporal picture of CD4(+) T cell effector regulation in the s...

journal_title：Immunity

authors： Honda T,Egen JG,Lämmermann T,Kastenmüller W,Torabi-Parizi P,Germain RN

更新日期：2014-02-20 00:00:00

abstract：:In the bone marrow, the special microenvironment niches nurture a pool of hematopoietic stem cells (HSCs). Many HSCs reside near the vasculature, but the molecular regulatory mechanism of niches for HSC maintenance remains unclear. Here we showed that the induced deletion of CXCR4, a receptor for CXC chemokine ligand ...

journal_title：Immunity

authors： Sugiyama T,Kohara H,Noda M,Nagasawa T

更新日期：2006-12-01 00:00:00

abstract：:Using a transgenic approach, we examined distal regulatory elements located in the IL-4 locus and the role of GATA-3 at these elements. The intergenic DNase I hypersensitive sites (HSS) showed strong enhancement, and the intronic enhancer (IE) and HS5/HS5a sites showed weaker enhancement of the IL-4 promoter. Elements...

journal_title：Immunity

authors： Lee GR,Fields PE,Flavell RA

更新日期：2001-04-01 00:00:00