Abstract:
:Production of immunoglobulin heavy chain (IgH) protein feeds back to terminate further V(H) gene recombination, a phenomenon also referred to as allelic exclusion. Here we provide evidence to support the proposition that allelic exclusion is the consequence of terminating signals that activate V(H) genes for recombination. For the largest V(H)J558 family of genes, this occurs by attenuating IL-7/IL-7R signals in pre-B cells. Loss of these signals reverts the V(H) locus to a chromatin state that is associated with hypoacetylated histones and is less accessible to nucleases. Furthermore, hyperacetylation and accessibility of unrearranged V(H) genes can be restored in allelically excluded splenic B cells by activating this pathway. Thus, transient signals mediate V(H) gene activation and inactivation during development.
journal_name
Immunityjournal_title
Immunityauthors
Chowdhury D,Sen Rdoi
10.1016/s1074-7613(03)00030-xkeywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
229-41issue
2eissn
1074-7613issn
1097-4180pii
S1074-7613(03)00030-Xjournal_volume
18pub_type
杂志文章相关文献
IMMUNITY文献大全abstract::The c-Myb transcription factor is crucial during definitive hematopoiesis. However, the embryonic lethality of Myb traditional null mutations has precluded analysis of c-Myb function in lymphocytes. Using tissue-specific inactivation at the Myb locus, we demonstrate that loss of Myb causes a partial block during B cel...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2005.08.005
更新日期:2005-09-01 00:00:00
abstract::CD4⁺ T cell differentiation is regulated by specialized antigen-presenting cells. Dendritic cells (DCs) produce cytokines that promote naive CD4⁺ T cell differentiation into T helper 1 (Th1), Th17, and inducible T regulatory (iTreg) cells. However, the initiation of Th2 cell responses remains poorly understood, althou...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2013.08.028
更新日期:2013-10-17 00:00:00
abstract::Previously, we described AGM-derived endothelial cell lines that either inhibited or permitted the development of erythroid or B cells. We utilized a differential gene expression method to isolate a chemokine, termed WECHE, from one of these cell lines. WECHE inhibited the formation of erythroid cells but had no effec...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80167-3
更新日期:2000-02-01 00:00:00
abstract::The peptidoglycan sensor Nod2 and the autophagy protein ATG16L1 have been linked to Crohn's disease (CD). Although Nod2 and the related sensor, Nod1, direct ATG16L1 to initiate anti-bacterial autophagy, whether ATG16L1 affects Nod-driven inflammation has not been examined. Here, we uncover an unanticipated autophagy-i...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2013.10.013
更新日期:2013-11-14 00:00:00
abstract::Destruction of li by proteolysis is required for MHC class II molecules to bind antigenic peptides, and for transport of the resulting complexes to the cell surface. The cysteine protease cathepsin S is highly expressed in spleen, lymphocytes, monocytes, and other class II-positive cells, and is inducible with interfe...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80249-6
更新日期:1996-04-01 00:00:00
abstract::In this issue of Immunity, Nagashima et al., Wallrapp et al., and Xu et al. demonstrate that the neuropeptide calcitonin gene-related peptide (CGRP) fine tunes type 2 innate immune response via suppressing group 2 innate lymphoid cells (ILC2s). ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2019.09.015
更新日期:2019-10-15 00:00:00
abstract::To explain why solid cancers grow or are rejected, we examined how the tumor stroma affected the level of antigen expression necessary to induce an immune response. We applied a tamoxifen-regulated Cre-loxP system to induce a model SIYRYYGL antigen recognized by the 2C T cell receptor. Solid tumors expressing the anti...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(02)00480-6
更新日期:2002-12-01 00:00:00
abstract::Knowledge of the regional tissue distribution of T cell subsets is a prerequisite for understanding protective immunity and the pathophysiology of T cell-mediated diseases. In this issue of Immunity, Sathaliyawala et al. (2012) present a comprehensive human tissue T cell analysis. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2013.01.006
更新日期:2013-01-24 00:00:00
abstract::In this issue of Immunity, Trompette et al. (2018) show that dietary fiber and short chain fatty acids reduce influenza A virus-associated immunopathology by enhancing CD8+ T cell effector function and by promoting the differentiation of alternatively activated macrophages. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2018.05.001
更新日期:2018-05-15 00:00:00
abstract::Direct and indirect cytopathic mechanisms have been proposed to account for the loss of CD4+ T cells after infection with human immunodeficiency virus type 1 (HIV-1). We report here that HIV-1 infection of the human thymus in vivo results in thymocyte depletion by at least two different mechanisms. Thymocytes within m...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90076-4
更新日期:1995-01-01 00:00:00
abstract::The Ikaros gene family encodes zinc finger DNA-binding proteins essential for lineage determination and control of proliferation in the lymphoid system. Here, we report that, in the nucleus of a T cell, a major fraction of Ikaros and Aiolos proteins associate with the DNA-dependent ATPase Mi-2 and histone deacetylases...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80034-5
更新日期:1999-03-01 00:00:00
abstract::Secondary diversification of the B cell repertoire by immunoglobulin gene somatic hypermutation in the germinal center (GC) is essential for providing the high-affinity antibody specificities required for long-term humoral immunity. While the risk to self-tolerance posed by inadvertent generation of self-reactive GC B...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2012.07.017
更新日期:2012-11-16 00:00:00
abstract::We have generated a site-directed transgenic (sd-tg) mouse model in which the JH locus has been replaced with a rearranged VDJ coding for the heavy chain of an anti-DNA antibody. In these mice, B cells expressing the anti-dsDNA specificity are negatively regulated. We observe a novel mechanism for B cell tolerance, re...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90064-0
更新日期:1995-12-01 00:00:00
abstract::Memory T cells provide long-lasting protective immunity, and distinct subpopulations of memory T cells drive chronic inflammatory diseases such as asthma. Asthma is a chronic allergic inflammatory disease with airway remodeling including fibrotic changes. The immunological mechanisms that induce airway fibrotic change...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.04.023
更新日期:2018-07-17 00:00:00
abstract::The decline in CD4+ T cell function with aging contributes to reduced vaccine efficacy. In this commentary, we discuss the factors leading to age-related changes in T cell function and propose how they may be overcome to enhance vaccine efficacy for the elderly. ...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2006.06.003
更新日期:2006-06-01 00:00:00
abstract::Crosspresentation of exogenous antigens (Ags) to CD8(+) T cells by dendritic cells generally requires their entry into the cytosol. Here we show that both soluble and phagocytosed extracellular Ags accessed the cytosol via molecular components required for endoplasmic reticulum (ER)-associated degradation (ERAD). Exog...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2006.08.017
更新日期:2006-10-01 00:00:00
abstract::In this issue of Immunity, studies from Atherly et al (2006) and Broussard et al. (2006) show that mice deficient in Tec kinases support development of a population of CD8(+) T cells with "innate-immune" properties. The similarity of these cells to NKT and MHC-class-Ib-restricted T cells suggests a common developmenta...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2006.07.006
更新日期:2006-07-01 00:00:00
abstract::Gallstone formation in adults is a common, yet incompletely understood disease process. In this issue, Muñoz et al. (2019) report a pathogenic link between neutrophil extracellular traps (NETs) and the formation of gallstones. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2019.08.015
更新日期:2019-09-17 00:00:00
abstract::Targeted mutagenesis in mice is a powerful tool for functional analysis of genes. However, genetic variation between embryonic stem cells (ESCs) used for targeting (previously almost exclusively 129-derived) and recipient strains (often C57BL/6J) typically results in congenic mice in which the targeted gene is flanked...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.06.011
更新日期:2015-07-21 00:00:00
abstract::Antimicrobial agents secreted into urine potentially play a powerful role in the defense of the urinary tract. In this issue of Immunity, Jaillon et al. (2014) describe a role for pentraxin 3 molecules in complementing the host's cellular innate immune responses to uropathogens. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2014.03.006
更新日期:2014-04-17 00:00:00
abstract::The ability of human CD1b molecules to present nonpeptide antigens is suggested by the T cell recognition of microbial lipids and lipoglycans in the presence of CD1b-expressing antigen-presenting cells. We demonstrate the high-affinity interaction of CD1b molecules with the acyl side chains of known T cell antigens, l...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80538-5
更新日期:1998-03-01 00:00:00
abstract::Neonatal female mice injected with the self ZP3 peptide are not tolerant to the peptide; they develop autoimmune ovarian disease (AOD) and autoantibody response 5 weeks later. ZP3 challenge leads to severe AOD and ZP3-specific T cell and antibody responses. In contrast, neonatal tolerance to foreign ZP3 peptide is est...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80245-9
更新日期:1997-01-01 00:00:00
abstract::In a recent issue of Nature, Borges da Silva et al. (2018) reveal that P2RX7, a receptor for extracellular ATP, promotes CD8 T cell memory by enhancing metabolic fitness. This work links an ancient "danger" signal with long-term immunity. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2018.08.009
更新日期:2018-08-21 00:00:00
abstract::The signaling pathways linked to membrane immunoglobulin (mIg) that are regulated by the coreceptors CD19 and CD22 are not known. The mitogen-activated protein (MAP) kinases ERK2, JNK, and p38 couple extracellular signals to transcriptional responses. The capacity of mIg to activate these MAP kinases is synergisticall...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80510-5
更新日期:1997-07-01 00:00:00
abstract::Activation of the RIG-I signaling molecule is essential for antiviral immunity but mechanisms downmodulating the response are ill defined. In this issue of Immunity, Rajput et al. (2011) describe caspase-8-mediated RIP1 cleavage as a key step for restricting RIG-I signaling. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2011.03.011
更新日期:2011-03-25 00:00:00
abstract::Inflammatory intestinal diseases are characterized by abnormal immune responses and affect distinct locations of the gastrointestinal tract. Although the role of several immune subsets in driving intestinal pathology has been studied, a system-wide approach that simultaneously interrogates all major lineages on a sing...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.04.014
更新日期:2016-05-17 00:00:00
abstract::Numerous regulatory programs have been identified that contribute to the restoration of homeostasis at the conclusion of immune responses and to safeguarding against the detrimental effects of chronic inflammation and autoimmune pathology. Malignant cells may usurp these pathways to create immunosuppressive networks t...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2012.03.004
更新日期:2012-03-23 00:00:00
abstract::What causes slow wound healing rates in diabetes is poorly understood. Wong et al. (2015) report that an increase in the deployment of neutrophil extracellular traps associated with hyperglycemia slows down wound healing. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2015.08.002
更新日期:2015-08-18 00:00:00
abstract::IgE antibodies may be protective in parasite immunity, but their aberrant production can lead to allergic disease and life-threatening anaphylaxis. Despite the importance of IgE regulation, few studies have directly examined the B cells that express IgE, because these cells are rare and difficult to detect. Here, we d...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2012.02.009
更新日期:2012-05-25 00:00:00
abstract::Macrophage/neutrophil-specific IL-4 receptor alpha-deficient mice (LysM(Cre)IL-4Ralpha(-/flox)) were generated to understand the role of IL-4/IL-13 responsive myeloid cells during Type 2 immune responses. LysM(Cre)IL-4Ralpha(-/flox) mice developed protective immunity against Nippostrongylus brasiliensis accompanied by...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(04)00107-4
更新日期:2004-05-01 00:00:00