Sweet NETs, Bitter Wounds.

abstract：:Memory T cells protect hosts from pathogen reinfection, but how these cells emerge from a pool of antigen-experienced T cells is unclear. Here, we show that mice lacking the transcription factor Foxo1 in activated CD8+ T cells have defective secondary, but not primary, responses to Listeria monocytogenes infection. Co...

journal_title：Immunity

authors： Kim MV,Ouyang W,Liao W,Zhang MQ,Li MO

更新日期：2013-08-22 00:00:00

abstract：:Susceptibility to glomerulonephritis (GN) and anti-dsDNA autoantibody production was analyzed in crosses with a newly developed systemic lupus erythematosus-susceptible inbred strain, NZM/Aeg2410. The mode of inheritance and the number and location of systemic lupus erythematosus-associated susceptibility loci were an...

journal_title：Immunity

authors： Morel L,Rudofsky UH,Longmate JA,Schiffenbauer J,Wakeland EK

更新日期：1994-06-01 00:00:00

abstract：:The epidermal growth factor receptor ligand Amphiregulin has a well-documented role in the restoration of tissue homeostasis after injury; however, the mechanism by which Amphiregulin contributes to wound repair remains unknown. Here we show that Amphiregulin functioned by releasing bioactive transforming growth facto...

journal_title：Immunity

authors： Minutti CM,Modak RV,Macdonald F,Li F,Smyth DJ,Dorward DA,Blair N,Husovsky C,Muir A,Giampazolias E,Dobie R,Maizels RM,Kendall TJ,Griggs DW,Kopf M,Henderson NC,Zaiss DM

更新日期：2019-03-19 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) are primary producers of type I interferon (IFN) in response to viruses. The IFN-producing capacity of pDCs is regulated by specific inhibitory receptors, yet none of the known receptors are conserved in evolution. We report that within the human immune system, receptor protein tyro...

journal_title：Immunity

authors： Bunin A,Sisirak V,Ghosh HS,Grajkowska LT,Hou ZE,Miron M,Yang C,Ceribelli M,Uetani N,Chaperot L,Plumas J,Hendriks W,Tremblay ML,Häcker H,Staudt LM,Green PH,Bhagat G,Reizis B

更新日期：2015-08-18 00:00:00

abstract：:The hallmark of bubonic plague is the presence of grotesquely swollen lymph nodes, called buboes. This frenzied inflammatory response to Yersinia pestis is poorly understood. In this issue of Immunity, St. John et al. (2014) explore the mechanism by which Y. pestis spreads and thus leads to this striking lymphadenopat...

journal_title：Immunity

authors： Davis KM,Isberg RR

更新日期：2014-09-18 00:00:00

abstract：:Acute hepatitis A (AHA) involves severe CD8+ T cell-mediated liver injury. Here we showed during AHA, CD8+ T cells specific to unrelated viruses became activated. Hepatitis A virus (HAV)-infected cells produced IL-15 that induced T cell receptor (TCR)-independent activation of memory CD8+ T cells. TCR-independent acti...

journal_title：Immunity

authors： Kim J,Chang DY,Lee HW,Lee H,Kim JH,Sung PS,Kim KH,Hong SH,Kang W,Lee J,Shin SY,Yu HT,You S,Choi YS,Oh I,Lee DH,Lee DH,Jung MK,Suh KS,Hwang S,Kim W,Park SH,Kim HJ,Shin EC

更新日期：2018-01-16 00:00:00

abstract：:Infiltration of regulatory T (Treg) cells into many tumor types correlates with poor patient prognoses. However, mechanisms of intratumoral Treg cell function remain to be elucidated. We investigated Treg cell function in a genetically engineered mouse model of lung adenocarcinoma and found that Treg cells suppressed ...

journal_title：Immunity

authors： Joshi NS,Akama-Garren EH,Lu Y,Lee DY,Chang GP,Li A,DuPage M,Tammela T,Kerper NR,Farago AF,Robbins R,Crowley DM,Bronson RT,Jacks T

更新日期：2015-09-15 00:00:00

abstract：:In this issue of Immunity, it is found that the downregulation of Pax-5 during antigen-dependent-terminal differentiation results in a substantial loss of B cell identity and the transition to a plasma cell state. ...

journal_title：Immunity

authors： Singh H,Sciammas R

更新日期：2006-03-01 00:00:00

abstract：:Two recent Immunity papers link peripheral tolerance with the ability of developing B cells to capture BAFF. These findings suggest that an increase in effective BAFF levels leads to autoreactive B cell maturation. ...

journal_title：Immunity

authors： Cancro MP

更新日期：2004-06-01 00:00:00

abstract：:Why HIV-specific CD8(+) T cells ultimately fail to clear or control HIV infection is not known. We show here that HIV-specific CD8(+) T cells exhibit increased sensitivity to CD95/Fas-induced apoptosis. This apoptosis is 3-fold higher compared to CMV-specific CD8(+) T cells from the same patients. HIV-specific CD8(+) ...

journal_title：Immunity

authors： Mueller YM,De Rosa SC,Hutton JA,Witek J,Roederer M,Altman JD,Katsikis PD

更新日期：2001-12-01 00:00:00

abstract：:Previously, we described AGM-derived endothelial cell lines that either inhibited or permitted the development of erythroid or B cells. We utilized a differential gene expression method to isolate a chemokine, termed WECHE, from one of these cell lines. WECHE inhibited the formation of erythroid cells but had no effec...

journal_title：Immunity

authors： Ohneda O,Ohneda K,Nomiyama H,Zheng Z,Gold SA,Arai F,Miyamoto T,Taillon BE,McIndoe RA,Shimkets RA,Lewin DA,Suda T,Lasky LA

更新日期：2000-02-01 00:00:00

abstract：:Toll-like receptors (TLRs) sense pathogen-associated molecular patterns to activate the production of inflammatory mediators. TLR4 recognizes lipopolysaccharide (LPS) and drives the secretion of inflammatory cytokines, often contributing to sepsis. We report that transient receptor potential melastatin-like 7 (TRPM7),...

journal_title：Immunity

authors： Schappe MS,Szteyn K,Stremska ME,Mendu SK,Downs TK,Seegren PV,Mahoney MA,Dixit S,Krupa JK,Stipes EJ,Rogers JS,Adamson SE,Leitinger N,Desai BN

更新日期：2018-01-16 00:00:00

abstract：:The cytoplasm is usually a DNA-free zone, but during fertilization, sperm DNA enters oocyte cytoplasm and could potentially trigger a response. Abe et al. (2017) identify NLRP14 as a germ-cell-specific negative regulator of DNA sensing that may be of particular importance during fertilization. ...

journal_title：Immunity

authors： Barber GN

更新日期：2017-04-18 00:00:00

abstract：:Multipotential naive CD4(+) T cells differentiate into distinct lineages including T helper 1 (Th1), Th2, Th17, and inducible T regulatory (iTreg) cells. The remarkable diversity of CD4(+) T cells begs the question whether the observed changes reflect terminal differentiation with heritable epigenetic modifications or...

journal_title：Immunity

authors： Wei G,Wei L,Zhu J,Zang C,Hu-Li J,Yao Z,Cui K,Kanno Y,Roh TY,Watford WT,Schones DE,Peng W,Sun HW,Paul WE,O'Shea JJ,Zhao K

更新日期：2009-01-16 00:00:00

abstract：:HIV-1 Envelope (Env) mediates viral-host membrane fusion after binding host-receptor CD4 and coreceptor. Soluble envelopes (SOSIPs), designed to mimic prefusion conformational states of virion-bound envelopes, are proposed immunogens for eliciting neutralizing antibodies, yet only static structures are available. To e...

journal_title：Immunity

authors： Stadtmueller BM,Bridges MD,Dam KM,Lerch MT,Huey-Tubman KE,Hubbell WL,Bjorkman PJ

更新日期：2018-08-21 00:00:00

abstract：:Studies of T cell anergy in vitro have led to the widely accepted view that anergy is induced by T cell antigen recognition without costimulation. We show that the induction of T cell anergy in vivo is due to an abortive T cell response that requires recognition of B7 molecules, since blocking B7 maintains T cells in ...

journal_title：Immunity

authors： Perez VL,Van Parijs L,Biuckians A,Zheng XX,Strom TB,Abbas AK

更新日期：1997-04-01 00:00:00

abstract：:Aiolos encodes a zinc finger DNA-binding protein that is highly expressed in mature B cells and is homologous to Ikaros. In the periphery of mice homozygous for an Aiolos-null mutation, B cells exhibit an activated cell surface phenotype and undergo augmented antigen receptor (BCR)-mediated in vitro proliferative resp...

journal_title：Immunity

authors： Wang JH,Avitahl N,Cariappa A,Friedrich C,Ikeda T,Renold A,Andrikopoulos K,Liang L,Pillai S,Morgan BA,Georgopoulos K

更新日期：1998-10-01 00:00:00

abstract：:Some endocrine organs are frequent targets of autoimmune attack. Here, we addressed the origin of autoimmune disease from the viewpoint of feedback control. Endocrine tissues maintain mass through feedback loops that balance cell proliferation and removal according to hormone-driven regulatory signals. We hypothesized...

journal_title：Immunity

authors： Korem Kohanim Y,Tendler A,Mayo A,Friedman N,Alon U

更新日期：2020-05-19 00:00:00

abstract：:CD4(+) T cells differentiate into phenotypically distinct T helper cells upon antigenic stimulation. Regulation of plasticity between these CD4(+) T-cell lineages is critical for immune homeostasis and prevention of autoimmune disease. However, the factors that regulate lineage stability are largely unknown. Here we i...

journal_title：Immunity

authors： Brown CC,Esterhazy D,Sarde A,London M,Pullabhatla V,Osma-Garcia I,Al-Bader R,Ortiz C,Elgueta R,Arno M,de Rinaldis E,Mucida D,Lord GM,Noelle RJ

更新日期：2015-03-17 00:00:00

abstract：:Genetic variation influences how the genome is interpreted in individuals and in mouse strains used to model immune responses. We developed approaches to utilize next-generation sequencing datasets to identify sequence variation in genes and enhancer elements in congenic and backcross mouse models. We defined genetic ...

journal_title：Immunity

authors： Chisolm DA,Cheng W,Colburn SA,Silva-Sanchez A,Meza-Perez S,Randall TD,Weinmann AS

更新日期：2019-07-16 00:00:00

abstract：:The intestinal mucosa promotes T cell responses that might be beneficial for effective mucosal vaccines. However, intestinal resident memory T (Trm) cell formation and function are poorly understood. We found that oral infection with Listeria monocytogenes induced a robust intestinal CD8 T cell response and blocking e...

journal_title：Immunity

authors： Sheridan BS,Pham QM,Lee YT,Cauley LS,Puddington L,Lefrançois L

更新日期：2014-05-15 00:00:00

abstract：:The tolerogenic microenvironment of the liver is associated with impaired hepatic T cell function. Here, we examined the contribution of liver-resident natural killer (LrNK) cells, a prominent hepatic NK cell compartment, to T cell antiviral responses in the liver. The number of virus-specific T cells increased in LrN...

journal_title：Immunity

authors： Zhou J,Peng H,Li K,Qu K,Wang B,Wu Y,Ye L,Dong Z,Wei H,Sun R,Tian Z

更新日期：2019-02-19 00:00:00

abstract：:Efficient unidirectional killing by cytotoxic T lymphocytes (CTL) requires translocation of the microtubule organizing center (MTOC) to the target cell contact site. Here we utilize modulated polarization microscopy and computerized 3D reconstruction of tubulin and LFA-1 immunofluorescence images to investigate how th...

journal_title：Immunity

authors： Kuhn JR,Poenie M

更新日期：2002-01-01 00:00:00

abstract：:Effector T cells are critical for clearance of pathogens from sites of infection. Like cytotoxic CD8(+) T cells, CD4(+) helper T cells have been shown to deliver effector molecules directionally toward the immunological synapse, suggesting that infected cells need to be engaged individually to receive effector signals...

journal_title：Immunity

authors： Müller AJ,Filipe-Santos O,Eberl G,Aebischer T,Späth GF,Bousso P

更新日期：2012-07-27 00:00:00

abstract：:Minor or histocompatibility (H) antigens are recognized by CD4+ and CD8+ T lymphocytes as short polymorphic peptides associated with MHC molecules. They are the targets of graft versus host and graft versus leukemia responses following bone marrow transplantation between HLA-identical siblings. Several genes encoding ...

journal_title：Immunity

authors： Scott D,Addey C,Ellis P,James E,Mitchell MJ,Saut N,Jurcevic S,Simpson E

更新日期：2000-06-01 00:00:00

abstract：:Genetic studies and other experimental data have linked inflammatory bowel diseases with inflammasome activation. In this issue of Immunity, Zaki et al. (2010) and Dupaul-Chicoine et al. (2010) provide a detailed characterization of the regulatory task of the inflammasome in intestinal epithelial cells. ...

journal_title：Immunity

authors： Siegmund B

更新日期：2010-03-26 00:00:00

abstract：:The participation of a specific subset of B cells and how they are regulated in cancer is unclear. Here, we demonstrate that the proportion of CD5(+) relative to interleukin-6 receptor α (IL-6Rα)-expressing B cells was greatly increased in tumors. CD5(+) B cells responded to IL-6 in the absence of IL-6Rα. IL-6 directl...

journal_title：Immunity

authors： Zhang C,Xin H,Zhang W,Yazaki PJ,Zhang Z,Le K,Li W,Lee H,Kwak L,Forman S,Jove R,Yu H

更新日期：2016-04-19 00:00:00

abstract：:PKCβ-null (Prkcb-/-) mice are severely immunodeficient. Here we show that mice whose B cells lack PKCβ failed to form germinal centers and plasma cells, which undermined affinity maturation and antibody production in response to immunization. Moreover, these mice failed to develop plasma cells in response to viral inf...

journal_title：Immunity

authors： Tsui C,Martinez-Martin N,Gaya M,Maldonado P,Llorian M,Legrave NM,Rossi M,MacRae JI,Cameron AJ,Parker PJ,Leitges M,Bruckbauer A,Batista FD

更新日期：2018-06-19 00:00:00

abstract：:The concept of an alternative pathway of macrophage activation has stimulated interest in its definition, mechanism, and functional significance in homeostasis and disease. We assess recent research in this field, argue for a restricted definition, and explore pathways by which the T helper 2 (Th2) cell cytokines inte...

journal_title：Immunity

authors： Gordon S,Martinez FO

更新日期：2010-05-28 00:00:00

abstract：:B cells diversify and affinity mature their antigen receptor repertoire in germinal centers (GCs). GC B cells receive help signals during transient interaction with T cells, yet it remains unknown how these transient T-B interactions in the light zone sustain the subsequent proliferative program of selected B cells th...

journal_title：Immunity

authors： Chou C,Verbaro DJ,Tonc E,Holmgren M,Cella M,Colonna M,Bhattacharya D,Egawa T

更新日期：2016-09-20 00:00:00