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Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.

Abstract：

:Studies of T cell anergy in vitro have led to the widely accepted view that anergy is induced by T cell antigen recognition without costimulation. We show that the induction of T cell anergy in vivo is due to an abortive T cell response that requires recognition of B7 molecules, since blocking B7 maintains T cells in an unactivated but functionally competent state. Furthermore, the induction of anergy is prevented by blocking CTLA-4, the inhibitory T cell receptor for B7 molecules. Thus, in vivo T cell anergy may be induced not because of a lack of costimulation, but as a result of specific recognition of B7 molecules by CTLA-4. In contrast, blocking CD28 on T cells prevents priming but not the induction of tolerance. Therefore, the outcome of antigen recognition by T cells is determined by the interaction of CD28 or CTLA-4 on the T cells with B7 molecules.

journal_name

Immunity

journal_title

Immunity

authors

Perez VL,Van Parijs L,Biuckians A,Zheng XX,Strom TB,Abbas AK

doi

10.1016/s1074-7613(00)80284-8

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

411-7

issue

4

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(00)80284-8

journal_volume

6

pub_type

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