Abstract：
:Superantigens (SAGs) activate T cells by simultaneously binding the Vbeta domain of the TCR and MHC class II molecules on antigen-presenting cells. The preferential expression of certain Valpha regions among SAG-reactive T cells has suggested that the TCR alpha chain may modulate the level of activation through an interaction with MHC. We demonstrate that the TCR alpha chain is required for maximum stabilization of the TCR-SAG-MHC complex and that the alpha chain increases the half-life of the complex to match those of TCR-peptide/MHC complexes. The site on the TCR alpha chain responsible for these effects is CDR2. Thus, the overall stability of the TCR-SAG-MHC complex is determined by the combination of three distinct interactions: TCR-SAG, SAG-MHC, and MHC-TCR.
journal_name
Immunityjournal_title
Immunityauthors
Andersen PS,Lavoie PM,Sékaly RP,Churchill H,Kranz DM,Schlievert PM,Karjalainen K,Mariuzza RAdoi
10.1016/s1074-7613(00)80047-3keywords:
subject
Has Abstractpub_date
1999-04-01 00:00:00pages
473-83issue
4eissn
1074-7613issn
1097-4180pii
S1074-7613(00)80047-3journal_volume
10pub_type
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