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Chemokines and the tissue-specific migration of lymphocytes.

Abstract：

:Tissue-selective trafficking of memory and effector T and B lymphocytes is mediated by unique combinations of adhesion molecules and chemokines. The discovery of several related epithelial-expressed chemokines (TECK/CCL25 in small intestine, CTACK/CCL27 in skin, and MEC/CCL28 in diverse mucosal sites) now highlights an important role for epithelial cells in controlling homeostatic lymphocyte trafficking, including the localization of cutaneous and intestinal memory T cells, and of IgA plasma cells. Constitutively expressed epithelial chemokines may help determine the character of local immune responses and contribute to the systemic organization of the immune system.

journal_name

Immunity

journal_title

Immunity

authors

Kunkel EJ,Butcher EC

doi

10.1016/s1074-7613(01)00261-8

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

1-4

issue

1

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(01)00261-8

journal_volume

16

pub_type

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