Abstract:
:Differentiation of naive T cells into mature Th2 cells is associated with the appearance of a complex pattern of DNase I hypersensitive (DH) sites within the IL-4/IL-13 cytokine gene cluster. We show here that targeted deletion of an inducible DH site, V(A), and the adjacent conserved DH site V (CNS-2) selectively compromises IL-4 gene transcription by differentiated Th2 cells and mast cells. In mast cells, the deletion abrogates IL-4 mRNA induction, an effect mimicked by deletion of the transcription factor NFAT1 (NFATc2), which binds DH site V(A). In T cells, the deletion impairs a process of response maturation, defined by progressive increases in IL-4 levels as Th2 differentiation proceeds. These results identify an essential enhancer which regulates IL-4 gene expression in two important cell lineages in vivo.
journal_name
Immunityjournal_title
Immunityauthors
Solymar DC,Agarwal S,Bassing CH,Alt FW,Rao Adoi
10.1016/s1074-7613(02)00334-5keywords:
subject
Has Abstractpub_date
2002-07-01 00:00:00pages
41-50issue
1eissn
1074-7613issn
1097-4180pii
S1074-7613(02)00334-5journal_volume
17pub_type
杂志文章相关文献
IMMUNITY文献大全abstract::Acute hepatitis A (AHA) involves severe CD8+ T cell-mediated liver injury. Here we showed during AHA, CD8+ T cells specific to unrelated viruses became activated. Hepatitis A virus (HAV)-infected cells produced IL-15 that induced T cell receptor (TCR)-independent activation of memory CD8+ T cells. TCR-independent acti...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.11.025
更新日期:2018-01-16 00:00:00
abstract::In a recent issue of Nature, Borges da Silva et al. (2018) reveal that P2RX7, a receptor for extracellular ATP, promotes CD8 T cell memory by enhancing metabolic fitness. This work links an ancient "danger" signal with long-term immunity. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2018.08.009
更新日期:2018-08-21 00:00:00
abstract::For a brief period during fetal lymph node organogenesis in mice, lymph node postcapillary high endothelial venules surprisingly express the Peyer's patch addressin MAdCAM-1. This expression allows initial seeding of this incipient structure by two unusual lymphocyte populations selectively expressing the Peyer's patc...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80371-4
更新日期:1997-10-01 00:00:00
abstract::B cell subsets expressing the transcription factor T-bet are associated with humoral immune responses and autoimmunity. Here, we examined the anatomic distribution, clonal relationships, and functional properties of T-bet+ and T-bet- memory B cells (MBCs) in the context of the influenza-specific immune response. In mi...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2020.03.020
更新日期:2020-05-19 00:00:00
abstract::We have characterized the CD1b-mediated presentation pathway for the mycobacterial lipoglycan lipoarabinomannan (LAM) in monocyte-derived antigen-presenting cells. The macrophage mannose receptor (MR) was responsible for uptake of LAM. Antagonism of MR function inhibited both the internalization of LAM and the present...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80425-2
更新日期:1997-02-01 00:00:00
abstract::Production of immunoglobulin heavy chain (IgH) protein feeds back to terminate further V(H) gene recombination, a phenomenon also referred to as allelic exclusion. Here we provide evidence to support the proposition that allelic exclusion is the consequence of terminating signals that activate V(H) genes for recombina...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(03)00030-x
更新日期:2003-02-01 00:00:00
abstract::Natural hosts for simian immunodeficiency virus (SIV) can be, and are often naturally, infected with species-specific SIVs, but do not develop acquired immunodeficiency syndrome (AIDS). These natural hosts maintain high SIV viral loads, but avoid immunodeficiency. Elucidating the mechanisms that allow natural hosts to...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2010.06.004
更新日期:2010-06-25 00:00:00
abstract::CD4+ T cells orchestrate immune responses and destruction of allogeneic organ transplants, but how this process is regulated on a transcriptional level remains unclear. Here, we demonstrated that interferon regulatory factor 4 (IRF4) was a key transcriptional determinant controlling T cell responses during transplanta...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.11.003
更新日期:2017-12-19 00:00:00
abstract::The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of common lymphoid and myeloid progenitors (CLP and CMP, respectively). In this report we present the first evidence for a nonredundant regu...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(02)00419-3
更新日期:2002-10-01 00:00:00
abstract::Diet-induced obesity can induce low-level inflammation and insulin resistance. Interleukin-1β (IL-1β) is one of the key proinflammatory cytokines that contributes to the generation of insulin resistance and diabetes, but the mechanisms that regulate obesity-driven inflammation are ill defined. Here we found reduced ex...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2014.11.013
更新日期:2014-12-18 00:00:00
abstract::Mouse NK cells express at least seven inhibitory Ly49 receptors. Here we employ a semiquantitative cell-cell adhesion assay as well as class I/peptide tetramers to provide a comprehensive analysis of specificities of Ly49 receptors for class I MHC molecules in eight MHC haplotypes. Different Ly49 receptors exhibited d...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80082-5
更新日期:1999-07-01 00:00:00
abstract::Kupffer cells, the phagocytes of fetal origin that line the liver sinusoids, are key contributors of host defense against enteroinvasive bacteria. Here, we found that infection by Listeria monocytogenes induced the early necroptotic death of Kupffer cells, which was followed by monocyte recruitment and an anti-bacteri...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2014.12.020
更新日期:2015-01-20 00:00:00
abstract::Inflammation can activate self-reactive CD8(+) T cells and induce autoimmunity. Here we show in a CD8(+) T cell-mediated model of type 1 diabetes that CD4(+)CD25(+) Treg cells prevent beta cell destruction following localized inflammation in the islets of Langerhans. These Treg cells accumulate preferentially in the p...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(02)00279-0
更新日期:2002-02-01 00:00:00
abstract::Inflammation mediated by antibody-antigen complexes contributes to autoimmune diseases. Mice deficient in the common Fcgamma-chain are protected from IgG-mediated glomerulonephritis and the reverse passive Arthus (RPA) reaction and FcR-bearing macrophages, and mast cells have been assigned primary roles in these proce...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2008.04.013
更新日期:2008-06-01 00:00:00
abstract::In this issue of Immunity, Conche et al. (2009) define an antigen-independent signaling pathway that is dependent on cyclic adenosine monophosphate and extracellular signal-regulated kinase and T cells for subsequent T cell antigen receptor signaling. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2008.12.007
更新日期:2009-01-16 00:00:00
abstract::Vaccine-induced memory B cell responses to evolving viruses like influenza A involve activation of pre-existing immunity and generation of new responses. To define the contribution of these two types of responses, we analyzed the response to H7N9 vaccination in H7N9-naive adults. We performed comprehensive comparisons...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2019.06.024
更新日期:2019-08-20 00:00:00
abstract::Particulate pollution is thought to function as an adjuvant that can induce allergic responses. However, the exact cell types and immunological factors that initiate the lung-specific immune responses are unclear. We found that upon intratracheal instillation, particulates such as aluminum salts and silica killed alve...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.11.010
更新日期:2016-12-20 00:00:00
abstract::Whereas dendritic cells (DCs) can be activated in many ways to trigger immunity, hardly anything is known about the mechanisms that counterbalance DC activation. Cyster and colleagues now demonstrate that the "self" molecule CD47 on erythrocytes critically restricts splenic DC activation. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2015.09.008
更新日期:2015-10-20 00:00:00
abstract::Activated CD8(+) T cells can differentiate into transient effector cells or long-lived memory cells. In this issue of Immunity, Joshi et al. (2007) suggest that inflammatory cytokines dictate this balance by regulating the expression of the transcription factor T-bet. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2007.08.003
更新日期:2007-08-01 00:00:00
abstract::The skin barrier is essential for host defense, but how the skin provides protection when the barrier is breached is not well understood. In this issue of Immunity, Gallo and colleagues report that keratinocytes integrate signals from antimicrobial peptides via MAVS signaling to amplify their antiviral immune response...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2016.07.001
更新日期:2016-07-19 00:00:00
abstract::Regulatory T cells (Treg cells) perform suppressive functions in disparate tissue environments and against many inflammatory insults, yet the tissue-enriched factor(s) that influence Treg cell phenotype and function remain largely unknown. We have shown a vital role for transforming growth factor-β (TGF-β) signals in ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.03.015
更新日期:2017-04-18 00:00:00
abstract::Immune tolerance against enteric commensal bacteria is important for preventing intestinal inflammation. Deletion of phosphoinositide-dependent protein kinase 1 (Pdk1) in T cells via Cd4-Cre induced chronic inflammation of the intestine despite the importance of PDK1 in T cell activation. Analysis of colonic intraepit...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2010.10.014
更新日期:2010-11-24 00:00:00
abstract::HIV-infected humans and SIV-infected rhesus macaques who remain healthy despite long-term infection exhibit exceptionally low levels of virus replication and active antiviral cellular immune responses. In contrast, sooty mangabey monkeys that represent natural hosts for SIV infection do not develop AIDS despite high l...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(03)00060-8
更新日期:2003-03-01 00:00:00
abstract::Gallstone formation in adults is a common, yet incompletely understood disease process. In this issue, Muñoz et al. (2019) report a pathogenic link between neutrophil extracellular traps (NETs) and the formation of gallstones. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2019.08.015
更新日期:2019-09-17 00:00:00
abstract::Different genetic alterations may lead to type I interferon (IFN) overproduction in human systemic lupus erythematosus (SLE). The increased bioavailability of type I IFN contributes to peripheral tolerance breakdown through the activation of immature myeloid dendritic cells (mDCs). IFN-matured mDCs activate autoreacti...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2006.08.010
更新日期:2006-09-01 00:00:00
abstract::The tolerogenic microenvironment of the liver is associated with impaired hepatic T cell function. Here, we examined the contribution of liver-resident natural killer (LrNK) cells, a prominent hepatic NK cell compartment, to T cell antiviral responses in the liver. The number of virus-specific T cells increased in LrN...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.12.024
更新日期:2019-02-19 00:00:00
abstract::Active research at the frontiers of immunology and neuroscience has identified multiple points of interaction and communication between the immune system and the nervous system. Immune cell activation stimulates neuronal circuits that regulate innate and adaptive immunity. Molecular mechanistic insights into the infla...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2017.06.008
更新日期:2017-06-20 00:00:00
abstract::Plasmacytoid dendritic cells (pDCs) are primary producers of type I interferon (IFN) in response to viruses. The IFN-producing capacity of pDCs is regulated by specific inhibitory receptors, yet none of the known receptors are conserved in evolution. We report that within the human immune system, receptor protein tyro...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.07.009
更新日期:2015-08-18 00:00:00
abstract::Reprogramming of cellular metabolism is crucial for T cells responding to environmental cues. Blagih et al. (2015) reveal that the kinase AMPK directs metabolic adaption of effector T cells upon nutrient limitation and contributes to immune responses in vivo. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2014.12.029
更新日期:2015-01-20 00:00:00
abstract::Much of the current understanding in hematopoietic stem cell differentiation into immune-cell lineages comes from mouse studies, but how well does it translate to the human system? ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2007.05.011
更新日期:2007-06-01 00:00:00