Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection.

abstract：:Major Histocompatibility Complex (MHC) class II molecules, including Human Leukocyte Antigen (HLA)-DR, present peptide fragments from proteins degraded in the endocytic pathway. HLA-DR is targeted to late-endocytic structures named MHC class II-containing Compartments (MIIC), where it interacts with HLA-DM. This chape...

journal_title：Immunity

authors： Zwart W,Griekspoor A,Kuijl C,Marsman M,van Rheenen J,Janssen H,Calafat J,van Ham M,Janssen L,van Lith M,Jalink K,Neefjes J

更新日期：2005-02-01 00:00:00

abstract：:CD4⁺ T cell differentiation is regulated by specialized antigen-presenting cells. Dendritic cells (DCs) produce cytokines that promote naive CD4⁺ T cell differentiation into T helper 1 (Th1), Th17, and inducible T regulatory (iTreg) cells. However, the initiation of Th2 cell responses remains poorly understood, althou...

journal_title：Immunity

authors： Gao Y,Nish SA,Jiang R,Hou L,Licona-Limón P,Weinstein JS,Zhao H,Medzhitov R

更新日期：2013-10-17 00:00:00

abstract：:Active research at the frontiers of immunology and neuroscience has identified multiple points of interaction and communication between the immune system and the nervous system. Immune cell activation stimulates neuronal circuits that regulate innate and adaptive immunity. Molecular mechanistic insights into the infla...

journal_title：Immunity

authors： Chavan SS,Pavlov VA,Tracey KJ

更新日期：2017-06-20 00:00:00

abstract：:PCR analyses of the kappaL chain locus in single B-lineage cells of wild-type, Ckappa-, or JCkappa-deficient homozygous or heterozygous mice often detect multiple in- and out-of-frame rearrangements at the kappaL and lambdaL loci. They are most frequent in small pre-BII cells and equally so in wild-type and kappaL cha...

journal_title：Immunity

authors： Yamagami T,ten Boekel E,Andersson J,Rolink A,Melchers F

更新日期：1999-09-01 00:00:00

abstract：:HLA-DM (DM) is a nonclassical MHC class II molecule that interacts with classical MHC II molecules in acidic compartments. During this association DM is supposed to catalyze the release of invariant chain (Ii)-derived CLIP peptides, as well as other peptides bound with low kinetic stability. Here we provide evidence t...

journal_title：Immunity

authors： Kropshofer H,Arndt SO,Moldenhauer G,Hämmerling GJ,Vogt AB

更新日期：1997-03-01 00:00:00

abstract：:Knowledge of the regional tissue distribution of T cell subsets is a prerequisite for understanding protective immunity and the pathophysiology of T cell-mediated diseases. In this issue of Immunity, Sathaliyawala et al. (2012) present a comprehensive human tissue T cell analysis. ...

journal_title：Immunity

authors： Neuenhahn M,Busch DH

更新日期：2013-01-24 00:00:00

abstract：:The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune responses, especially adaptive immune responses to SARS-CoV-2 infection. Here, we collected blood from COVID-19 patients who have recently become virus-free, and therefo...

journal_title：Immunity

authors： Ni L,Ye F,Cheng ML,Feng Y,Deng YQ,Zhao H,Wei P,Ge J,Gou M,Li X,Sun L,Cao T,Wang P,Zhou C,Zhang R,Liang P,Guo H,Wang X,Qin CF,Chen F,Dong C

更新日期：2020-06-16 00:00:00

abstract：:Foxp3(+) Treg cells express transcription factors normally expressed by specific T helper cells at sites of inflammation. In this issue of Immunity, Koch et al. (2012) and Hall et al. (2012) demonstrate that IFN-γ and IL-27 distinctly induces T-bet(+) Treg cells via STAT-1 transcription factor activation. ...

journal_title：Immunity

authors： Ohkura N,Sakaguchi S

更新日期：2012-09-21 00:00:00

abstract：:Combination antiretroviral therapy for HIV infection improves immune function and eliminates the risk of AIDS-related complications but does not restore full health. HIV-infected adults have excess risk of cardiovascular, liver, kidney, bone, and neurologic diseases. Many markers of inflammation are elevated in HIV di...

journal_title：Immunity

authors： Deeks SG,Tracy R,Douek DC

更新日期：2013-10-17 00:00:00

abstract：:Antigen-dependent T cell activation drives the formation of signaling microclusters containing the adaptor SLP-76. Costimulatory integrins regulate SLP-76 phosphorylation and could influence SLP-76 microclusters in the integrin-rich periphery of the immune synapse. We report that costimulation by the integrin VLA-4 (a...

journal_title：Immunity

authors： Nguyen K,Sylvain NR,Bunnell SC

更新日期：2008-06-01 00:00:00

abstract：:Production of immunoglobulin heavy chain (IgH) protein feeds back to terminate further V(H) gene recombination, a phenomenon also referred to as allelic exclusion. Here we provide evidence to support the proposition that allelic exclusion is the consequence of terminating signals that activate V(H) genes for recombina...

journal_title：Immunity

authors： Chowdhury D,Sen R

更新日期：2003-02-01 00:00:00

abstract：:The mechanism by which regulatory T cells control the germinal center response is unknown. In this issue of Immunity, Wing et al. (2014) and Sage et al. (2014) demonstrate that CTLA-4 is a critical effector molecule used by regulatory T cells to control the germinal center. ...

journal_title：Immunity

authors： Linterman MA,Denton AE

更新日期：2014-12-18 00:00:00

abstract：:The classical model of hematopoiesis established in the mouse postulates that lymphoid cells originate from a founder population of common lymphoid progenitors. Here, using a modeling approach in humanized mice, we showed that human lymphoid development stemmed from distinct populations of CD127- and CD127+ early lymp...

journal_title：Immunity

authors： Alhaj Hussen K,Vu Manh TP,Guimiot F,Nelson E,Chabaane E,Delord M,Barbier M,Berthault C,Dulphy N,Alberdi AJ,Burlen-Defranoux O,Socié G,Bories JC,Larghero J,Vanneaux V,Verhoeyen E,Wirth T,Dalod M,Gluckman JC,Cumano A

更新日期：2017-10-17 00:00:00

abstract：:HLA-DM removes CLIP and other loosely bound peptides from MHC class II molecules. The crystal structures of class II molecules and of HLA-DM have not permitted identification of their interaction sites. Here, we describe mutations in class II that impair interactions with DM. Libraries of randomly mutagenized DR3 alph...

journal_title：Immunity

authors： Doebele RC,Busch R,Scott HM,Pashine A,Mellins ED

更新日期：2000-10-01 00:00:00

abstract：:The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of common lymphoid and myeloid progenitors (CLP and CMP, respectively). In this report we present the first evidence for a nonredundant regu...

journal_title：Immunity

authors： Sitnicka E,Bryder D,Theilgaard-Mönch K,Buza-Vidas N,Adolfsson J,Jacobsen SE

更新日期：2002-10-01 00:00:00

abstract：:The transcription factor GATA3 is crucial for the differentiation of naive CD4(+) T cells into T helper 2 (Th2) cells. Here, we show that deletion of Gata3 allowed the appearance of interferon-gamma (IFN-gamma)-producing cells in the absence of interleukin-12 (IL-12) and IFN-gamma. Such IFN-gamma production was transc...

journal_title：Immunity

authors： Yagi R,Junttila IS,Wei G,Urban JF Jr,Zhao K,Paul WE,Zhu J

更新日期：2010-04-23 00:00:00

abstract：:B-lymphoid and myeloid development are markedly perturbed in a unique transgenic mouse strain, max 41. Pro-B, pre-B, and B lymphocytes were severely reduced but granulocytes were greatly elevated. This phenotype could be adoptively transferred with bone marrow cells. It was not alleviated by bcl-2 or myc transgenes th...

journal_title：Immunity

authors： Lindeman GJ,Adams JM,Cory S,Harris AW

更新日期：1994-09-01 00:00:00

abstract：:Autophagy is a fundamental biological process of the eukaryotic cell contributing to diverse cellular and physiological functions including cell-autonomous defense against intracellular pathogens. Here, we screened the Rab family of membrane trafficking regulators for effects on autophagic elimination of Mycobacterium...

journal_title：Immunity

authors： Pilli M,Arko-Mensah J,Ponpuak M,Roberts E,Master S,Mandell MA,Dupont N,Ornatowski W,Jiang S,Bradfute SB,Bruun JA,Hansen TE,Johansen T,Deretic V

更新日期：2012-08-24 00:00:00

abstract：:Inflammasomes are supramolecular organizing centers that operate to drive interleukin-1 (IL-1)-dependent inflammation. Depending on context, inflammatory caspases act upstream or downstream of inflammasome assembly, serving as the principal enzymes that control activities of these organelles. In this review, we discus...

journal_title：Immunity

authors： Evavold CL,Kagan JC

更新日期：2019-10-15 00:00:00

abstract：:Different genetic alterations may lead to type I interferon (IFN) overproduction in human systemic lupus erythematosus (SLE). The increased bioavailability of type I IFN contributes to peripheral tolerance breakdown through the activation of immature myeloid dendritic cells (mDCs). IFN-matured mDCs activate autoreacti...

journal_title：Immunity

authors： Banchereau J,Pascual V

更新日期：2006-09-01 00:00:00

abstract：:Peripheral blood monocytes are a heterogeneous population of circulating leukocytes. Using a murine adoptive transfer system to probe monocyte homing and differentiation in vivo, we identified two functional subsets among murine blood monocytes: a short-lived CX(3)CR1(lo)CCR2(+)Gr1(+) subset that is actively recruited...

journal_title：Immunity

authors： Geissmann F,Jung S,Littman DR

更新日期：2003-07-01 00:00:00

abstract：:Mouse NK cells express at least seven inhibitory Ly49 receptors. Here we employ a semiquantitative cell-cell adhesion assay as well as class I/peptide tetramers to provide a comprehensive analysis of specificities of Ly49 receptors for class I MHC molecules in eight MHC haplotypes. Different Ly49 receptors exhibited d...

journal_title：Immunity

authors： Hanke T,Takizawa H,McMahon CW,Busch DH,Pamer EG,Miller JD,Altman JD,Liu Y,Cado D,Lemonnier FA,Bjorkman PJ,Raulet DH

更新日期：1999-07-01 00:00:00

abstract：:Commensal microbiota confers a goldilocks state of alertness to pathogens, yet restrains deleterious inflammation. In this issue of Immunity, Geuking et al. (2011) demonstrate that a minimal bacterial community of the Schaedler flora establishes a balance between pro- and anti-inflammatory T cells in the gut. ...

journal_title：Immunity

authors： Rudensky AY,Chervonsky AV

更新日期：2011-05-27 00:00:00

abstract：:Fas receptor-induced apoptosis plays critical roles in immune homeostasis. However, most of the signal transduction events distal to Fas ligation have not been elucidated. Here, we show that Ras is activated following ligation of Fas on lymphoid lines. The activation of Ras is a critical component of this apoptotic pa...

journal_title：Immunity

authors： Gulbins E,Bissonnette R,Mahboubi A,Martin S,Nishioka W,Brunner T,Baier G,Baier-Bitterlich G,Byrd C,Lang F

更新日期：1995-04-01 00:00:00

abstract：:Immunological functions of mast cells are currently considered to be much broader than the original role of mast cells in IgE-driven allergic disease. The spectrum of proposed mast cell functions includes areas as diverse as the regulation of innate and adaptive immune responses, protective immunity against viral, mic...

journal_title：Immunity

authors： Rodewald HR,Feyerabend TB

更新日期：2012-07-27 00:00:00

abstract：:Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE). Here we have provided evidence for the involvement of a damage-associated DNA modification in the detection of cytosolic DNA. The oxidized base 8-hydroxyguanosine (8-OHG), a marker of oxi...

journal_title：Immunity

authors： Gehrke N,Mertens C,Zillinger T,Wenzel J,Bald T,Zahn S,Tüting T,Hartmann G,Barchet W

更新日期：2013-09-19 00:00:00

abstract：:Transcriptional regulation of the Nos2 gene encoding inducible nitric oxide synthase (iNOS) requires type I interferon (IFN-I) signaling and additional signals emanating from pattern recognition receptors. Here we showed sequential and cooperative contributions of the transcription factors ISGF3 (a complex containing ...

journal_title：Immunity

authors： Farlik M,Reutterer B,Schindler C,Greten F,Vogl C,Müller M,Decker T

更新日期：2010-07-23 00:00:00

abstract：:To establish whether the widely expressed regulator of Src family kinases Csk contributes to the control of acute inflammation in vivo, we inactivated csk in granulocytes by conditional mutagenesis (Cre/loxP). Mutant mice (Csk-GEcre) developed acute multifocal inflammation in skin and lung. Animals were protected from...

journal_title：Immunity

authors： Thomas RM,Schmedt C,Novelli M,Choi BK,Skok J,Tarakhovsky A,Roes J

更新日期：2004-02-01 00:00:00

abstract：:Activated CD8(+) T cells can differentiate into transient effector cells or long-lived memory cells. In this issue of Immunity, Joshi et al. (2007) suggest that inflammatory cytokines dictate this balance by regulating the expression of the transcription factor T-bet. ...

journal_title：Immunity

authors： Hamilton SE,Jameson SC

更新日期：2007-08-01 00:00:00

abstract：:Antigenic peptides are translocated by the TAP peptide transporter from the cytosol into the endoplasmic reticulum (ER) for loading onto MHC class I molecules. Peptides that fail to bind need to be removed from the ER. Here we provide evidence that peptide export utilizes the Sec61p translocon as demonstrated by block...

journal_title：Immunity

authors： Koopmann JO,Albring J,Hüter E,Bulbuc N,Spee P,Neefjes J,Hämmerling GJ,Momburg F

更新日期：2000-07-01 00:00:00