Abstract:
:Antigenic peptides are translocated by the TAP peptide transporter from the cytosol into the endoplasmic reticulum (ER) for loading onto MHC class I molecules. Peptides that fail to bind need to be removed from the ER. Here we provide evidence that peptide export utilizes the Sec61p translocon as demonstrated by blocking this channel with bacterial exotoxin. Peptide export interferes with the retrotranslocation of beta2-microglobulin from the ER to the cytosol, suggesting similar pathways for the disposal of proteins and oligopeptides. Peptide export requires ATP supply to the ER lumen but is independent of ATP hydrolysis.
journal_name
Immunityjournal_title
Immunityauthors
Koopmann JO,Albring J,Hüter E,Bulbuc N,Spee P,Neefjes J,Hämmerling GJ,Momburg Fdoi
10.1016/s1074-7613(00)00013-3keywords:
subject
Has Abstractpub_date
2000-07-01 00:00:00pages
117-27issue
1eissn
1074-7613issn
1097-4180pii
S1074-7613(00)00013-3journal_volume
13pub_type
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