当前位置： SCI文献检索 > IMMUNITY期刊下所有文献 > Monocyte subsets responsible for immunoglobulin G-dependent effector functions in vivo.

Monocyte subsets responsible for immunoglobulin G-dependent effector functions in vivo.

Abstract：

:Immunoglobulin G (IgG) antibodies confer protection against pathogenic microorganisms, serve as therapeutics in tumor therapy, and are involved in destruction of healthy tissues during autoimmune diseases. Understanding the molecular pathways and effector cell types involved in antibody-mediated effector functions is a prerequisite to modulate these activities. In this study we used two independent model systems to identify innate immune effector cells required for IgG activity in vivo. We first defined the precise repertoire of receptors for the IgG Fc fragment (FcγR) on innate immune effector cells in the blood and on tissue-resident macrophage populations. Despite expression of relevant activating FcγRs on various phagocyte populations, our data indicate that the majority of these cell types are dispensable for IgG activity in vivo. In contrast, IgG-dependent effector functions were selectively impaired in animals lacking the CX(3)CR1(hi)Ly6C(lo)CD11c(int) monocyte subset, which expressed the full set of FcγRs required for IgG activity.

journal_name

Immunity

journal_title

Immunity

authors

Biburger M,Aschermann S,Schwab I,Lux A,Albert H,Danzer H,Woigk M,Dudziak D,Nimmerjahn F

doi

10.1016/j.immuni.2011.11.009

subject

Has Abstract

pub_date

2011-12-23 00:00:00

pages

932-44

issue

6

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(11)00498-5

journal_volume

35

pub_type

杂志文章

相关文献

IMMUNITY文献大全
  • RAS and PD-L1: A Masters' Liaison in Cancer Immune Evasion.

    abstract：:Mutant RAS is a major oncoprotein in human cancer and PD-L1 is a key driver of cancer immune evasion. In this issue of Immunity, Coelho et al. (2017) demonstrate that oncogenic RAS signaling promotes tumor immune escape by stabilizing PD-L1 mRNA. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2017.12.001

    authors： Glodde N,Hölzel M

    更新日期：2017-12-19 00:00:00

  • Nucleic Acid Sensors as Therapeutic Targets for Human Disease.

    abstract：:Innate immune sensors that detect nucleic acids are attractive targets for therapeutic intervention because of their diverse roles in many disease processes. In detecting RNA and DNA from either self or non-self, nucleic acid sensors mediate the pathogenesis of many autoimmune and inflammatory conditions. Despite prom...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2020.04.004

    authors： McWhirter SM,Jefferies CA

    更新日期：2020-07-14 00:00:00

  • Tumor recognition following Vgamma9Vdelta2 T cell receptor interactions with a surface F1-ATPase-related structure and apolipoprotein A-I.

    abstract：:Vgamma9Vdelta2 T lymphocytes, a major gammadelta T lymphocyte subset in humans, display cytolytic activity against various tumor cells upon recognition of yet uncharacterized structures. Here, we show that an entity related to the mitochondrial F1-ATPase is expressed on tumor cell surface and promotes tumor recognitio...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2004.11.012

    authors： Scotet E,Martinez LO,Grant E,Barbaras R,Jenö P,Guiraud M,Monsarrat B,Saulquin X,Maillet S,Estève JP,Lopez F,Perret B,Collet X,Bonneville M,Champagne E

    更新日期：2005-01-01 00:00:00

  • Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes.

    abstract：:For several days after antigenic stimulation, human cytolytic T lymphocyte (CTL) clones exhibit a decrease in their effector activity and in their binding to human leukocyte antigen (HLA)-peptide tetramers. We observed that, when in this state, CTLs lose the colocalization of the T cell receptor (TCR) and CD8. Effecto...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2008.01.011

    authors： Demotte N,Stroobant V,Courtoy PJ,Van Der Smissen P,Colau D,Luescher IF,Hivroz C,Nicaise J,Squifflet JL,Mourad M,Godelaine D,Boon T,van der Bruggen P

    更新日期：2008-03-01 00:00:00

  • Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation.

    abstract：:Particulate pollution is thought to function as an adjuvant that can induce allergic responses. However, the exact cell types and immunological factors that initiate the lung-specific immune responses are unclear. We found that upon intratracheal instillation, particulates such as aluminum salts and silica killed alve...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.11.010

    authors： Kuroda E,Ozasa K,Temizoz B,Ohata K,Koo CX,Kanuma T,Kusakabe T,Kobari S,Horie M,Morimoto Y,Nakajima S,Kabashima K,Ziegler SF,Iwakura Y,Ise W,Kurosaki T,Nagatake T,Kunisawa J,Takemura N,Uematsu S,Hayashi M,Aoshi T

    更新日期：2016-12-20 00:00:00

  • Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals.

    abstract：:Inflammation can activate self-reactive CD8(+) T cells and induce autoimmunity. Here we show in a CD8(+) T cell-mediated model of type 1 diabetes that CD4(+)CD25(+) Treg cells prevent beta cell destruction following localized inflammation in the islets of Langerhans. These Treg cells accumulate preferentially in the p...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(02)00279-0

    authors： Green EA,Choi Y,Flavell RA

    更新日期：2002-02-01 00:00:00

  • Feeling a little SYK after mixing BAFF with BCR.

    abstract：:In this issue of Immunity, Schweighoffer et al. (2013) report that full BAFF responsiveness in B cells requires the tyrosine kinase Syk and that BAFF may co-opt components of the B cell receptor in transmitting its survival signal. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2013.03.001

    authors： Infantino S,Tarlinton DM

    更新日期：2013-03-21 00:00:00

  • Virus-specific CD8 T cells in peripheral tissues are more resistant to apoptosis than those in lymphoid organs.

    abstract：:CD8 T cells persist at high frequencies in peripheral organs after resolution of an immune response, and their presence in the periphery is important for resistance to secondary challenge. We show here that LCMV-specific T cells in peripheral tissue (peritoneal cavity, lung, fat pads) reacted much less with the apopto...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(03)00116-x

    authors： Wang XZ,Stepp SE,Brehm MA,Chen HD,Selin LK,Welsh RM

    更新日期：2003-05-01 00:00:00

  • DEER Spectroscopy Measurements Reveal Multiple Conformations of HIV-1 SOSIP Envelopes that Show Similarities with Envelopes on Native Virions.

    abstract：:HIV-1 Envelope (Env) mediates viral-host membrane fusion after binding host-receptor CD4 and coreceptor. Soluble envelopes (SOSIPs), designed to mimic prefusion conformational states of virion-bound envelopes, are proposed immunogens for eliciting neutralizing antibodies, yet only static structures are available. To e...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2018.06.017

    authors： Stadtmueller BM,Bridges MD,Dam KM,Lerch MT,Huey-Tubman KE,Hubbell WL,Bjorkman PJ

    更新日期：2018-08-21 00:00:00

  • A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or differentiation.

    abstract：:To investigate the specificity of cytokine signals in hematopoietic differentiation, we generated mice with a targeted mutation of their G-CSF receptor (G-CSFR) such that the cytoplasmic (signaling) domain of the G-CSFR is replaced with the cytoplasmic domain of the erythropoietin receptor. In homozygous mutant mice, ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80090-4

    authors： Semerad CL,Poursine-Laurent J,Liu F,Link DC

    更新日期：1999-08-01 00:00:00

  • Retinoic acid imprints gut-homing specificity on T cells.

    abstract：:For a preferential homing of T cells to the gut, expression of the integrin alpha4beta7 and the chemokine receptor CCR9 is essential and is induced by antigenic stimulation with dendritic cells from the gut-associated lymphoid organs. Here, we show that the vitamin A (retinol) metabolite, retinoic acid, enhances the e...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2004.08.011

    authors： Iwata M,Hirakiyama A,Eshima Y,Kagechika H,Kato C,Song SY

    更新日期：2004-10-01 00:00:00

  • Immunological tolerance to a pancreatic antigen as a result of local expression of TNFalpha by islet beta cells.

    abstract：:Recent experiments have suggested that tumor necrosis factor alpha (TNFalpha) can down-regulate islet-specific T cells and prevent the development of autoimmune diabetes. Here we demonstrate that transgenic mice expressing both TNFalpha and the Leishmania major LACK antigen in the pancreas (RIP-TNFalpha/RIP-LACK) exhi...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80361-1

    authors： McSorley SJ,Soldera S,Malherbe L,Carnaud C,Locksley RM,Flavell RA,Glaichenhaus N

    更新日期：1997-09-01 00:00:00

  • Follicular Dendritic Cell Activation by TLR Ligands Promotes Autoreactive B Cell Responses.

    abstract：:A hallmark of autoimmunity in murine models of lupus is the formation of germinal centers (GCs) in lymphoid tissues where self-reactive B cells expand and differentiate. In the host response to foreign antigens, follicular dendritic cells (FDCs) maintain GCs through the uptake and cycling of complement-opsonized immun...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.12.014

    authors： Das A,Heesters BA,Bialas A,O'Flynn J,Rifkin IR,Ochando J,Mittereder N,Carlesso G,Herbst R,Carroll MC

    更新日期：2017-01-17 00:00:00

  • The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching.

    abstract：:To define the role of TRAF proteins in CD40-dependent isotype switching in B cells, we introduced wild-type (WT) and mutant CD40 transgenes that lacked the binding motifs for TRAF6 (CD40deltaTRAF6), TRAF2 and TRAF3 (CD40deltaTRAF2/3), or both (CD40deltaTRAFs) into B cells of CD40(-/-) mice. The in vivo isotype switch ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(02)00394-1

    authors： Jabara H,Laouini D,Tsitsikov E,Mizoguchi E,Bhan A,Castigli E,Dedeoglu F,Pivniouk V,Brodeur S,Geha R

    更新日期：2002-09-01 00:00:00

  • Hypermutation in shark immunoglobulin light chain genes results in contiguous substitutions.

    abstract：:Among 631 substitutions present in 90 nurse shark immunoglobulin light chain somatic mutants, 338 constitute 2-4 bp stretches of adjacent changes. An absence of mutations in perinatal sequences and the bias for one mutating V gene in adults suggest that the diversification is antigen dependent. The substitutions share...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(02)00300-x

    authors： Lee SS,Tranchina D,Ohta Y,Flajnik MF,Hsu E

    更新日期：2002-04-01 00:00:00

  • The Cytokines of Asthma.

    abstract：:Asthma is a chronic inflammatory airway disease associated with type 2 cytokines interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus overproduction, bronchial hyperresponsiveness (BHR), and immunogloubulin E (IgE) synthesis. However, only half of asthma patients exhibit signs of an exacerba...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2019.03.018

    authors： Lambrecht BN,Hammad H,Fahy JV

    更新日期：2019-04-16 00:00:00

  • Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1.

    abstract：:Adaptor proteins act as conduits to channel upstream signals into downstream effector branches. Two B cell-associated adaptors, Bam32 and Carma1, regulate the ERK, JNK, and NF-kappaB branches of the BCR signaling pathway. Recent studies of Bam32-/- and Carma1-/- mice suggest that each adaptor controls a distinct condu...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/s1074-7613(03)00303-0

    authors： Niiro H,Clark EA

    更新日期：2003-11-01 00:00:00

  • Clec2d Joins the Cell Death Sensor Ranks.

    abstract：:Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. In this issue of Immunity, Lai et al. (2020) uncover a role for the C-type lectin receptor Clec2d as a sensor of cell death, which directly detects histones released during necro...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2019.12.015

    authors： Del Fresno C,Sancho D

    更新日期：2020-01-14 00:00:00

  • SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production.

    abstract：:The Toll-like receptor 3 (TLR3) and TLR4-signaling pathway that involves the adaptor protein TRIF activates type I interferon (IFN) and proinflammatory cytokine expression. Little is known about how TRIF pathway-dependent gene expression is regulated. SH2-containing protein tyrosine phosphatase 2 (SHP-2) is a widely e...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2006.10.014

    authors： An H,Zhao W,Hou J,Zhang Y,Xie Y,Zheng Y,Xu H,Qian C,Zhou J,Yu Y,Liu S,Feng G,Cao X

    更新日期：2006-12-01 00:00:00

  • Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential.

    abstract：:Cognate interactions of naive T cells with antigen-presenting dendritic cells require physical cell-cell contacts leading to signal induction and T cell activation. Using a three-dimensional collagen matrix videomicroscopy model for ovalbumin peptide-specific activation of murine and oxidative mitogenesis of human T c...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)00032-7

    authors： Gunzer M,Schäfer A,Borgmann S,Grabbe S,Zänker KS,Bröcker EB,Kämpgen E,Friedl P

    更新日期：2000-09-01 00:00:00

  • Mass Cytometry of the Human Mucosal Immune System Identifies Tissue- and Disease-Associated Immune Subsets.

    abstract：:Inflammatory intestinal diseases are characterized by abnormal immune responses and affect distinct locations of the gastrointestinal tract. Although the role of several immune subsets in driving intestinal pathology has been studied, a system-wide approach that simultaneously interrogates all major lineages on a sing...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.04.014

    authors： van Unen V,Li N,Molendijk I,Temurhan M,Höllt T,van der Meulen-de Jong AE,Verspaget HW,Mearin ML,Mulder CJ,van Bergen J,Lelieveldt BP,Koning F

    更新日期：2016-05-17 00:00:00

  • Plasma Cells Are Obligate Effectors of Enhanced Myelopoiesis in Aging Bone Marrow.

    abstract：:Aging results in increased myelopoiesis, which is linked to the increased incidence of myeloid leukemias and production of myeloid-derived suppressor cells. Here, we examined the contribution of plasma cells (PCs) to age-related increases in myelopoiesis, as PCs exhibit immune regulatory function and sequester in bone...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2019.06.006

    authors： Pioli PD,Casero D,Montecino-Rodriguez E,Morrison SL,Dorshkind K

    更新日期：2019-08-20 00:00:00

  • Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression.

    abstract：:Transcriptional regulation of the Nos2 gene encoding inducible nitric oxide synthase (iNOS) requires type I interferon (IFN-I) signaling and additional signals emanating from pattern recognition receptors. Here we showed sequential and cooperative contributions of the transcription factors ISGF3 (a complex containing ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2010.07.001

    authors： Farlik M,Reutterer B,Schindler C,Greten F,Vogl C,Müller M,Decker T

    更新日期：2010-07-23 00:00:00

  • Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2.

    abstract：:Myeloid-derived suppressor cells (MDSCs) and cancer stem cells (CSCs) are important cellular components in the cancer microenvironment and may affect cancer phenotype and patient outcome. The nature of MDSCs and their interaction with CSCs in ovarian carcinoma are unclear. We examined the interaction between MDSCs and...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2013.08.025

    authors： Cui TX,Kryczek I,Zhao L,Zhao E,Kuick R,Roh MH,Vatan L,Szeliga W,Mao Y,Thomas DG,Kotarski J,Tarkowski R,Wicha M,Cho K,Giordano T,Liu R,Zou W

    更新日期：2013-09-19 00:00:00

  • Langerhans cells activate naive self-antigen-specific CD8 T cells in the steady state.

    abstract：:TCR transgenic mice that express a peptide antigen in keratinocytes develop a lethal CD8 T cell-dependent autoimmune disease. We employed an adoptive transfer system to understand this disease and show that transfer of low numbers of naive CD8 T cells into peptide transgenic mice caused chronic skin disease. The antig...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2004.07.019

    authors： Mayerova D,Parke EA,Bursch LS,Odumade OA,Hogquist KA

    更新日期：2004-09-01 00:00:00

  • Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against malaria.

    abstract：:Antibodies play major roles in immunity to malaria; however, a limited understanding of mechanisms mediating protection is a major barrier to vaccine development. We have demonstrated that acquired human anti-malarial antibodies promote complement deposition on the merozoite to mediate inhibition of erythrocyte invasi...

    journal_title：Immunity

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.immuni.2015.02.012

    authors： Boyle MJ,Reiling L,Feng G,Langer C,Osier FH,Aspeling-Jones H,Cheng YS,Stubbs J,Tetteh KK,Conway DJ,McCarthy JS,Muller I,Marsh K,Anders RF,Beeson JG

    更新日期：2015-03-17 00:00:00

  • Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b.

    abstract：:Antigen presentation and microbial killing are critical arms of host defense that depend upon cargo trafficking into lysosomes. Yet, the molecular regulators of traffic into lysosomes are only partly understood. Here, using a lysosome-dependent immunological screen of a trafficking shRNA library, we identified the Arf...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2011.06.009

    authors： Garg S,Sharma M,Ung C,Tuli A,Barral DC,Hava DL,Veerapen N,Besra GS,Hacohen N,Brenner MB

    更新日期：2011-08-26 00:00:00

  • Inhibition of IFN-gamma signaling by an Epstein-Barr virus immediate-early protein.

    abstract：:Viruses have evolved elaborate mechanisms to target many aspects of the host's immune response. The cytokine IFN-gamma plays a central role in resistance of the host to infection via direct antiviral effects as well as modulation of the immune response. In this study, we demonstrate that the Epstein-Barr virus (EBV) i...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(01)00226-6

    authors： Morrison TE,Mauser A,Wong A,Ting JP,Kenney SC

    更新日期：2001-11-01 00:00:00

  • A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex.

    abstract：:The elongated complementary-determining region (CDR) 3beta found in the unliganded KB5-C20 TCR protrudes from the antigen binding site and prevents its docking onto the peptide/MHC (pMHC) surface according to a canonical diagonal orientation. We now present the crystal structure of a complex involving the KB5-C20 TCR ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(02)00288-1

    authors： Reiser JB,Grégoire C,Darnault C,Mosser T,Guimezanes A,Schmitt-Verhulst AM,Fontecilla-Camps JC,Mazza G,Malissen B,Housset D

    更新日期：2002-03-01 00:00:00

  • The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation.

    abstract：:T cell activation is tightly regulated to avoid autoimmunity. Gene related to anergy in lymphocytes (GRAIL, encoded by Rnf128) is an E3 ubiquitin ligase associated with T cell tolerance. Here, we generated and analyzed GRAIL-deficient mice and found they were resistant to immune tolerance induction and exhibited great...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2010.05.002

    authors： Nurieva RI,Zheng S,Jin W,Chung Y,Zhang Y,Martinez GJ,Reynolds JM,Wang SL,Lin X,Sun SC,Lozano G,Dong C

    更新日期：2010-05-28 00:00:00