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Virus-specific CD8 T cells in peripheral tissues are more resistant to apoptosis than those in lymphoid organs.

Abstract：

:CD8 T cells persist at high frequencies in peripheral organs after resolution of an immune response, and their presence in the periphery is important for resistance to secondary challenge. We show here that LCMV-specific T cells in peripheral tissue (peritoneal cavity, lung, fat pads) reacted much less with the apoptotic marker Annexin-V than those in spleen and lymph nodes. This was not due to a TCR-based selection. In comparison to lymphoid tissue, T cells in the periphery expressed lower levels of Fas and Fas ligand and were resistant to activation-induced cell death in vitro. This may contribute to the survival of nondividing peripheral memory T cells, enabling them to efficiently function without being driven into apoptosis.

journal_name

Immunity

journal_title

Immunity

authors

Wang XZ,Stepp SE,Brehm MA,Chen HD,Selin LK,Welsh RM

doi

10.1016/s1074-7613(03)00116-x

keywords:

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

631-42

issue

5

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(03)00116-X

journal_volume

18

pub_type

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