当前位置： SCI文献检索 > IMMUNITY期刊下所有文献 > Hypermutation in shark immunoglobulin light chain genes results in contiguous substitutions.

Hypermutation in shark immunoglobulin light chain genes results in contiguous substitutions.

Abstract：

:Among 631 substitutions present in 90 nurse shark immunoglobulin light chain somatic mutants, 338 constitute 2-4 bp stretches of adjacent changes. An absence of mutations in perinatal sequences and the bias for one mutating V gene in adults suggest that the diversification is antigen dependent. The substitutions shared no patterns, and the absence of donor sequences, including from family members, supports the idea that most changes arose from nontemplated mutation. The tandem mutations as a group are distinguished by consistently fewer transition changes and an A bias. We suggest this is one of several pathways of hypermutation diversifying shark antigen-receptor genes--point mutations, tandem mutations, and mutations with a G-C preference--that coevolved with or preceded gene rearrangement.

journal_name

Immunity

journal_title

Immunity

authors

Lee SS,Tranchina D,Ohta Y,Flajnik MF,Hsu E

doi

10.1016/s1074-7613(02)00300-x

keywords:

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

571-82

issue

4

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(02)00300-X

journal_volume

16

pub_type

杂志文章

相关文献

IMMUNITY文献大全
  • Analysis of a SARS-CoV-2-Infected Individual Reveals Development of Potent Neutralizing Antibodies with Limited Somatic Mutation.

    abstract：:Antibody responses develop following SARS-CoV-2 infection, but little is known about their epitope specificities, clonality, binding affinities, epitopes, and neutralizing activity. We isolated B cells specific for the SARS-CoV-2 envelope glycoprotein spike (S) from a COVID-19-infected subject 21 days after the onset ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2020.06.001

    authors： Seydoux E,Homad LJ,MacCamy AJ,Parks KR,Hurlburt NK,Jennewein MF,Akins NR,Stuart AB,Wan YH,Feng J,Whaley RE,Singh S,Boeckh M,Cohen KW,McElrath MJ,Englund JA,Chu HY,Pancera M,McGuire AT,Stamatatos L

    更新日期：2020-07-14 00:00:00

  • Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential.

    abstract：:Cognate interactions of naive T cells with antigen-presenting dendritic cells require physical cell-cell contacts leading to signal induction and T cell activation. Using a three-dimensional collagen matrix videomicroscopy model for ovalbumin peptide-specific activation of murine and oxidative mitogenesis of human T c...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)00032-7

    authors： Gunzer M,Schäfer A,Borgmann S,Grabbe S,Zänker KS,Bröcker EB,Kämpgen E,Friedl P

    更新日期：2000-09-01 00:00:00

  • TRAF3: uncovering the real but restricted role in human.

    abstract：:In this issue of Immunity, Pérez de Diego et al. (2010) report a primary human immune deficiency involving a TRAF protein and show that human immunity to the virus HSV-1 is critically dependent on TRAF3. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2010.09.008

    authors： Bowie AG

    更新日期：2010-09-24 00:00:00

  • Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cells.

    abstract：:Memory lymphocytes are characterized by their ability to exhibit a rapid response to the recall antigen, in which differential transcription is important, yet the underlying mechanism is not understood. We report here a genome-wide analysis of histone methylation on two histone H3 lysine residues (H3K4me3 and H3K27me3...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2009.05.006

    authors： Araki Y,Wang Z,Zang C,Wood WH 3rd,Schones D,Cui K,Roh TY,Lhotsky B,Wersto RP,Peng W,Becker KG,Zhao K,Weng NP

    更新日期：2009-06-19 00:00:00

  • Functional assessment of precursors from murine bone marrow suggests a sequence of early B lineage differentiation events.

    abstract：:Most lineage marker-negative (Lin-)TdT+ cells from murine marrow lack CD34 but display c-kit at low density as well as IL-7Ralpha and Flk-2/Flt-3 receptors. Single cells with these characteristics generated CD45RA+CD19- as well as CD19+ lymphocytes in culture. CD45RA+CD19- marrow cells were resolved into three nonover...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80186-7

    authors： Tudor KS,Payne KJ,Yamashita Y,Kincade PW

    更新日期：2000-03-01 00:00:00

  • NLRC3 puts the brakes on STING.

    abstract：:NOD-like receptors (NLRs) are increasingly implicated in regulating pathogen-sensing pathways. In this issue of Immunity, Zhang et al. (2014) describe a role for NLRC3 in regulating STING and the inflammatory response to cytosolic DNA. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2014.02.007

    authors： Mangan MS,Latz E

    更新日期：2014-03-20 00:00:00

  • Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2.

    abstract：:Myeloid-derived suppressor cells (MDSCs) and cancer stem cells (CSCs) are important cellular components in the cancer microenvironment and may affect cancer phenotype and patient outcome. The nature of MDSCs and their interaction with CSCs in ovarian carcinoma are unclear. We examined the interaction between MDSCs and...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2013.08.025

    authors： Cui TX,Kryczek I,Zhao L,Zhao E,Kuick R,Roh MH,Vatan L,Szeliga W,Mao Y,Thomas DG,Kotarski J,Tarkowski R,Wicha M,Cho K,Giordano T,Liu R,Zou W

    更新日期：2013-09-19 00:00:00

  • Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.

    abstract：:The thymus generates major histocompatibility complex (MHC)-restricted alphabetaT cells that only recognize antigenic ligands in association with MHC or MHC-like molecules. We hypothesized that MHC specificity might be imposed on a broader alphabetaTCR repertoire during thymic selection by CD4 and CD8 coreceptors that...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2007.10.007

    authors： Van Laethem F,Sarafova SD,Park JH,Tai X,Pobezinsky L,Guinter TI,Adoro S,Adams A,Sharrow SO,Feigenbaum L,Singer A

    更新日期：2007-11-01 00:00:00

  • GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase.

    abstract：:Indoleamine 2,3 dioxygenase (IDO) catabolizes the amino acid tryptophan. IDO-expressing immunoregulatory dendritic cells (DCs) have been implicated in settings including tumors, autoimmunity, and transplant tolerance. However, the downstream molecular mechanisms by which IDO functions to regulate T cell responses rema...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2005.03.013

    authors： Munn DH,Sharma MD,Baban B,Harding HP,Zhang Y,Ron D,Mellor AL

    更新日期：2005-05-01 00:00:00

  • Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on Human and Murine Plasmacytoid Dendritic Cells.

    abstract：:Plasmacytoid dendritic cells (pDCs) are primary producers of type I interferon (IFN) in response to viruses. The IFN-producing capacity of pDCs is regulated by specific inhibitory receptors, yet none of the known receptors are conserved in evolution. We report that within the human immune system, receptor protein tyro...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2015.07.009

    authors： Bunin A,Sisirak V,Ghosh HS,Grajkowska LT,Hou ZE,Miron M,Yang C,Ceribelli M,Uetani N,Chaperot L,Plumas J,Hendriks W,Tremblay ML,Häcker H,Staudt LM,Green PH,Bhagat G,Reizis B

    更新日期：2015-08-18 00:00:00

  • Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect.

    abstract：:The molecular basis of T cell anergy is not completely understood. We show that in antigen-primed anergic murine CD4(+) T cells the linker for activation of T cells (LAT) is hypophosphorylated upon CD3/CD28 restimulation. Signaling events downstream of LAT (PLCgamma1 phosphorylation and p85 [PI3-K] association) were i...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2006.03.011

    authors： Hundt M,Tabata H,Jeon MS,Hayashi K,Tanaka Y,Krishna R,De Giorgio L,Liu YC,Fukata M,Altman A

    更新日期：2006-05-01 00:00:00

  • Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis.

    abstract：:Inflammatory bowel disease (IBD) results from a dysregulated interaction between the microbiota and a genetically susceptible host. Genetic studies have linked TNFSF15 polymorphisms and its protein TNF-like ligand 1A (TL1A) with IBD, but the functional role of TL1A is not known. Here, we found that adherent IBD-associ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2018.10.014

    authors： Castellanos JG,Woo V,Viladomiu M,Putzel G,Lima S,Diehl GE,Marderstein AR,Gandara J,Perez AR,Withers DR,Targan SR,Shih DQ,Scherl EJ,Longman RS

    更新日期：2018-12-18 00:00:00

  • c-Myb is critical for B cell development and maintenance of follicular B cells.

    abstract：:The c-Myb transcription factor is crucial during definitive hematopoiesis. However, the embryonic lethality of Myb traditional null mutations has precluded analysis of c-Myb function in lymphocytes. Using tissue-specific inactivation at the Myb locus, we demonstrate that loss of Myb causes a partial block during B cel...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2005.08.005

    authors： Thomas MD,Kremer CS,Ravichandran KS,Rajewsky K,Bender TP

    更新日期：2005-09-01 00:00:00

  • Tec kinases in T cell development: a clue behind the mask?

    abstract：:In this issue of Immunity, studies from Atherly et al (2006) and Broussard et al. (2006) show that mice deficient in Tec kinases support development of a population of CD8(+) T cells with "innate-immune" properties. The similarity of these cells to NKT and MHC-class-Ib-restricted T cells suggests a common developmenta...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2006.07.006

    authors： Hogquist KA

    更新日期：2006-07-01 00:00:00

  • Toll signaling in flies and mammals: two sorts of MyD88.

    abstract：:The mammalian MyD88 signaling molecule participates in Toll receptor signaling within the cytoplasm. In this issue of Immunity, Marek and Kagan (2012) report that Drosophila (d)MyD88 acts instead at the plasma membrane to sort the signaling adaptor Tube. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2012.04.001

    authors： Goto A,Imler JL

    更新日期：2012-04-20 00:00:00

  • The small GTPase Rac2 controls phagosomal alkalinization and antigen crosspresentation selectively in CD8(+) dendritic cells.

    abstract：:A unique subpopulation of spleen dendritic cells (DCs) that express the CD8 surface marker efficiently present phagocytosed antigens to CD8(+) T lymphocytes in a process called "crosspresentation," which initiates cytotoxic immune responses. We now show that the small GTPase Rac2 plays a critical role in antigen cross...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2009.01.013

    authors： Savina A,Peres A,Cebrian I,Carmo N,Moita C,Hacohen N,Moita LF,Amigorena S

    更新日期：2009-04-17 00:00:00

  • Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology.

    abstract：:Macrophage/neutrophil-specific IL-4 receptor alpha-deficient mice (LysM(Cre)IL-4Ralpha(-/flox)) were generated to understand the role of IL-4/IL-13 responsive myeloid cells during Type 2 immune responses. LysM(Cre)IL-4Ralpha(-/flox) mice developed protective immunity against Nippostrongylus brasiliensis accompanied by...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(04)00107-4

    authors： Herbert DR,Hölscher C,Mohrs M,Arendse B,Schwegmann A,Radwanska M,Leeto M,Kirsch R,Hall P,Mossmann H,Claussen B,Förster I,Brombacher F

    更新日期：2004-05-01 00:00:00

  • Induction of rapid T cell activation and tolerance by systemic presentation of an orally administered antigen.

    abstract：:To understand how orally introduced antigen regulates peripheral immune responses, we fed cytochrome c protein to mice transgenic for the beta chain of a cytochrome c-specific TCR and followed the antigen-specific T cell responses with a cyt c/I-Ek tetramer staining reagent. We find that within 6 hr of cytochrome c ad...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80571-3

    authors： Gütgemann I,Fahrer AM,Altman JD,Davis MM,Chien YH

    更新日期：1998-06-01 00:00:00

  • Balance and imbalance in the immune system: life on the edge.

    abstract：:CTLA-4 is a key immune checkpoint in maintaining self-tolerance, which can be co-opted by cancer to evade immune attack. In Science, Kuehn et al. (2014) describe clinical manifestations from inherited heterozygous CTLA4 mutations, and some are reminiscent of immune-related consequences from anti-CTLA-4 cancer therapy....

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2014.11.005

    authors： Topalian SL,Sharpe AH

    更新日期：2014-11-20 00:00:00

  • "MIATA"-minimal information about T cell assays.

    abstract：:Immunotherapy, especially therapeutic vaccination, has a great deal of potential in the treatment of cancer and certain infectious diseases such as HIV (Allison et al., 2006; Fauci et al., 2008; Feldmann and Steinman, 2005). Numerous vaccine candidates have been tested in patients with a variety of tumor types and chr...

    journal_title：Immunity

    pub_type： 信件

    doi：10.1016/j.immuni.2009.09.007

    authors： Janetzki S,Britten CM,Kalos M,Levitsky HI,Maecker HT,Melief CJ,Old LJ,Romero P,Hoos A,Davis MM

    更新日期：2009-10-16 00:00:00

  • Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death.

    abstract：:La Crosse virus (LACV), a zoonotic Bunyavirus, is a major cause of pediatric viral encephalitis in the United States. A hallmark of neurological diseases caused by LACV and other encephalitic viruses is the induction of neuronal cell death. Innate immune responses have been implicated in neuronal damage, but no mechan...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2013.02.013

    authors： Mukherjee P,Woods TA,Moore RA,Peterson KE

    更新日期：2013-04-18 00:00:00

  • Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2.

    abstract：:Human memory B cells that carry mutated IgV region genes were isolated from tonsils by negative selection of IgD+ naive B cells and CD38+ germinal center B cells and plasma cells. They were mainly found within the intraepithelial areas, but not in the B cell follicles of human tonsils. Memory B cells but not naive B c...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/1074-7613(95)90048-9

    authors： Liu YJ,Barthélémy C,de Bouteiller O,Arpin C,Durand I,Banchereau J

    更新日期：1995-03-01 00:00:00

  • Shedding B cell identity.

    abstract：:In this issue of Immunity, it is found that the downregulation of Pax-5 during antigen-dependent-terminal differentiation results in a substantial loss of B cell identity and the transition to a plasma cell state. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2006.03.005

    authors： Singh H,Sciammas R

    更新日期：2006-03-01 00:00:00

  • alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases.

    abstract：:Two families of protein tyrosine kinases (PTKs), the Src and Syk/ZAP-70 families, are required for T cell development. Lck is the major Src family member required for thymopoiesis, since there is a severe deficit of CD4+CD8+ thymocytes and mature T cells in its absence. However, some peripheral T cells are evident in ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80499-9

    authors： van Oers NS,Lowin-Kropf B,Finlay D,Connolly K,Weiss A

    更新日期：1996-11-01 00:00:00

  • Viral Anti-CRISPR Tactics: No Success without Sacrifice.

    abstract：:Co-evolution with their bacterial hosts has led to viral countermeasures against CRISPR-mediated immunity. In a recent issue of Cell, Landsberger et al. (2018) and Borges et al. (2018) report that cooperation among bacteriophages and multiple infection events are necessary to overcome CRISPR immune responses. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2018.08.023

    authors： van Gent M,Gack MU

    更新日期：2018-09-18 00:00:00

  • Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors.

    abstract：:Mouse NK cells express at least seven inhibitory Ly49 receptors. Here we employ a semiquantitative cell-cell adhesion assay as well as class I/peptide tetramers to provide a comprehensive analysis of specificities of Ly49 receptors for class I MHC molecules in eight MHC haplotypes. Different Ly49 receptors exhibited d...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80082-5

    authors： Hanke T,Takizawa H,McMahon CW,Busch DH,Pamer EG,Miller JD,Altman JD,Liu Y,Cado D,Lemonnier FA,Bjorkman PJ,Raulet DH

    更新日期：1999-07-01 00:00:00

  • Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity.

    abstract：:Recent evidence has suggested that signals other than those from Toll-like receptors (TLRs) could contribute to the elicitation of antigen-specific immunity. Therefore, we examined the role of the Nod-like receptor (NLR) family member, Nod1, in the generation of adaptive immune responses. Our findings show that innate...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2007.03.009

    authors： Fritz JH,Le Bourhis L,Sellge G,Magalhaes JG,Fsihi H,Kufer TA,Collins C,Viala J,Ferrero RL,Girardin SE,Philpott DJ

    更新日期：2007-04-01 00:00:00

  • The transcription factor Foxo1 controls central-memory CD8+ T cell responses to infection.

    abstract：:Memory T cells protect hosts from pathogen reinfection, but how these cells emerge from a pool of antigen-experienced T cells is unclear. Here, we show that mice lacking the transcription factor Foxo1 in activated CD8+ T cells have defective secondary, but not primary, responses to Listeria monocytogenes infection. Co...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2013.07.013

    authors： Kim MV,Ouyang W,Liao W,Zhang MQ,Li MO

    更新日期：2013-08-22 00:00:00

  • NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING.

    abstract：:Stimulator of interferon genes (STING, also named MITA, MYPS, or ERIS) is an intracellular DNA sensor that induces type I interferon through its interaction with TANK-binding kinase 1 (TBK1). Here we found that the nucleotide-binding, leucine-rich-repeat-containing protein, NLRC3, reduced STING-dependent innate immune...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2014.01.010

    authors： Zhang L,Mo J,Swanson KV,Wen H,Petrucelli A,Gregory SM,Zhang Z,Schneider M,Jiang Y,Fitzgerald KA,Ouyang S,Liu ZJ,Damania B,Shu HB,Duncan JA,Ting JP

    更新日期：2014-03-20 00:00:00

  • The Integrin alpha9beta1 contributes to granulopoiesis by enhancing granulocyte colony-stimulating factor receptor signaling.

    abstract：:The integrin alpha9beta1 is widely expressed on neutrophils, smooth muscle, hepatocytes, endothelia, and some epithelia. We now show that mice lacking this integrin have a dramatic defect in neutrophil development, with decreased numbers of granulocyte precursors in bone marrow and impaired differentiation of bone mar...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2006.10.013

    authors： Chen C,Huang X,Atakilit A,Zhu QS,Corey SJ,Sheppard D

    更新日期：2006-12-01 00:00:00