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c-Myb is critical for B cell development and maintenance of follicular B cells.

Abstract：

:The c-Myb transcription factor is crucial during definitive hematopoiesis. However, the embryonic lethality of Myb traditional null mutations has precluded analysis of c-Myb function in lymphocytes. Using tissue-specific inactivation at the Myb locus, we demonstrate that loss of Myb causes a partial block during B cell development at the pro-B to pre-B cell transition, resulting in greatly decreased output of new B cells from the bone marrow. Furthermore, we demonstrate that Myb is not essential for the proliferation of splenic B cells, but that loss of c-Myb function prevents normal B cell homeostasis due to decreased splenic B cell survival. Decreased survival is accompanied by hyporesponsiveness to the B cell survival factor BLyS (also termed BAFF), decreased expression of the BLyS receptor 3 (BR3), and altered regulation of PKCdelta nuclear accumulation. Thus, c-Myb is important during multiple stages of B-lymphopoiesis.

journal_name

Immunity

journal_title

Immunity

authors

Thomas MD,Kremer CS,Ravichandran KS,Rajewsky K,Bender TP

doi

10.1016/j.immuni.2005.08.005

keywords:

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

275-86

issue

3

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(05)00244-X

journal_volume

23

pub_type

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