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Differential TCR signaling regulates apoptosis and immunopathology during antigen responses in vivo.

Abstract：

:Clonal selection theories postulate that lymphocyte fate is regulated by antigen receptor specificity. However, lymphocyte apoptosis is induced through nonantigen-specific receptors such as Fas (CD95/APO-1) or TNFR. We define a selective TCR that controls apoptosis by Fas or TNFR stimulation. Variant ligands can deliver this "competence to die" signal without the full TCR signals necessary for cytokine synthesis. These partial agonists regulate T cell deletion in vivo even when Fas or TNF is provided by T cells of unrelated specificity, but they do not cause the liver necrosis that is associated with T cell elimination by the full agonist. Thus, selective signaling ligands regulate T cell deletion and immune damage in vivo and may be important for peripheral T cell tolerance.

journal_name

Immunity

journal_title

Immunity

authors

Combadière B,Reis e Sousa C,Trageser C,Zheng LX,Kim CR,Lenardo MJ

doi

10.1016/s1074-7613(00)80613-5

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

305-13

issue

3

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(00)80613-5

journal_volume

9

pub_type

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