Toll-like receptor 9, what o'clock is it?

abstract：:Pancreatic adenocarcinoma (PDAC) is mostly refractory to immunotherapies. In this issue of Immunity, Li et al. (2018) generate a library of clonal PDAC tumors to examine the tumor-intrinsic features shaping the anti-tumor immune response and find that tumor cell-derived CXCL1 directly blunts T cell infiltration and re...

journal_title：Immunity

authors： Horton B,Spranger S

更新日期：2018-07-17 00:00:00

abstract：:TCR transgenic mice that express a peptide antigen in keratinocytes develop a lethal CD8 T cell-dependent autoimmune disease. We employed an adoptive transfer system to understand this disease and show that transfer of low numbers of naive CD8 T cells into peptide transgenic mice caused chronic skin disease. The antig...

journal_title：Immunity

authors： Mayerova D,Parke EA,Bursch LS,Odumade OA,Hogquist KA

更新日期：2004-09-01 00:00:00

abstract：:MicroRNA (miRNA)-deficient helper T cells exhibit abnormal IFN-γ production and decreased proliferation. However, the contributions of individual miRNAs to this phenotype remain poorly understood. We conducted a screen for miRNA function in primary T cells and identified individual miRNAs that rescue the defects assoc...

journal_title：Immunity

authors： Steiner DF,Thomas MF,Hu JK,Yang Z,Babiarz JE,Allen CD,Matloubian M,Blelloch R,Ansel KM

更新日期：2011-08-26 00:00:00

abstract：:Immunological functions of mast cells are currently considered to be much broader than the original role of mast cells in IgE-driven allergic disease. The spectrum of proposed mast cell functions includes areas as diverse as the regulation of innate and adaptive immune responses, protective immunity against viral, mic...

journal_title：Immunity

authors： Rodewald HR,Feyerabend TB

更新日期：2012-07-27 00:00:00

abstract：:CD1d-restricted natural killer T cells (NKT cells) possess a wide range of effector and regulatory activities that are related to their ability to secrete both T helper 1 (Th1) cell- and Th2 cell-type cytokines. We analyzed presentation of NKT cell activating alpha galactosylceramide (alphaGalCer) analogs that give pr...

journal_title：Immunity

authors： Im JS,Arora P,Bricard G,Molano A,Venkataswamy MM,Baine I,Jerud ES,Goldberg MF,Baena A,Yu KO,Ndonye RM,Howell AR,Yuan W,Cresswell P,Chang YT,Illarionov PA,Besra GS,Porcelli SA

更新日期：2009-06-19 00:00:00

abstract：:Stimulator of interferon genes (STING, also named MITA, MYPS, or ERIS) is an intracellular DNA sensor that induces type I interferon through its interaction with TANK-binding kinase 1 (TBK1). Here we found that the nucleotide-binding, leucine-rich-repeat-containing protein, NLRC3, reduced STING-dependent innate immune...

journal_title：Immunity

authors： Zhang L,Mo J,Swanson KV,Wen H,Petrucelli A,Gregory SM,Zhang Z,Schneider M,Jiang Y,Fitzgerald KA,Ouyang S,Liu ZJ,Damania B,Shu HB,Duncan JA,Ting JP

更新日期：2014-03-20 00:00:00

abstract：:Activated CD8(+) T cells can differentiate into transient effector cells or long-lived memory cells. In this issue of Immunity, Joshi et al. (2007) suggest that inflammatory cytokines dictate this balance by regulating the expression of the transcription factor T-bet. ...

journal_title：Immunity

authors： Hamilton SE,Jameson SC

更新日期：2007-08-01 00:00:00

abstract：:Fas receptor-induced apoptosis plays critical roles in immune homeostasis. However, most of the signal transduction events distal to Fas ligation have not been elucidated. Here, we show that Ras is activated following ligation of Fas on lymphoid lines. The activation of Ras is a critical component of this apoptotic pa...

journal_title：Immunity

authors： Gulbins E,Bissonnette R,Mahboubi A,Martin S,Nishioka W,Brunner T,Baier G,Baier-Bitterlich G,Byrd C,Lang F

更新日期：1995-04-01 00:00:00

abstract：:HLA-DM removes CLIP and other loosely bound peptides from MHC class II molecules. The crystal structures of class II molecules and of HLA-DM have not permitted identification of their interaction sites. Here, we describe mutations in class II that impair interactions with DM. Libraries of randomly mutagenized DR3 alph...

journal_title：Immunity

authors： Doebele RC,Busch R,Scott HM,Pashine A,Mellins ED

更新日期：2000-10-01 00:00:00

abstract：:Type 2 innate lymphoid cells (ILC2s) are part of a large family of ILCs that are important effectors in innate immunity, lymphoid organogenesis, and tissue remodeling. ILC2s mediate parasite expulsion but also contribute to airway inflammation, emphasizing the functional similarity between these cells and Th2 cells. C...

journal_title：Immunity

authors： Mjösberg J,Bernink J,Golebski K,Karrich JJ,Peters CP,Blom B,te Velde AA,Fokkens WJ,van Drunen CM,Spits H

更新日期：2012-10-19 00:00:00

abstract：:Cytotoxic T lymphocytes (CTLs) use polarized secretion to rapidly destroy virally infected and tumor cells. To understand the temporal relationships between key events leading to secretion, we used high-resolution 4D imaging. CTLs approached targets with actin-rich projections at the leading edge, creating an initiall...

journal_title：Immunity

authors： Ritter AT,Asano Y,Stinchcombe JC,Dieckmann NM,Chen BC,Gawden-Bone C,van Engelenburg S,Legant W,Gao L,Davidson MW,Betzig E,Lippincott-Schwartz J,Griffiths GM

更新日期：2015-05-19 00:00:00

abstract：:Effector CD8(+) T cells scan tissues to locate and kill infected host cells. In this issue of Immunity, Hickman et al. (2015) show that the exploration is not random: infected monocytes attract their assassins by secreting chemokines, which accelerates clearance of epicutaneous vaccinia virus infection. ...

journal_title：Immunity

authors： Beura LK,Masopust D

更新日期：2015-03-17 00:00:00

abstract：:IgE antibodies may be protective in parasite immunity, but their aberrant production can lead to allergic disease and life-threatening anaphylaxis. Despite the importance of IgE regulation, few studies have directly examined the B cells that express IgE, because these cells are rare and difficult to detect. Here, we d...

journal_title：Immunity

authors： Yang Z,Sullivan BM,Allen CD

更新日期：2012-05-25 00:00:00

abstract：:Memory CD8+ T cell quantity and quality determine protective efficacy against reinfection. Heterologous prime boost vaccination minimizes contraction of anamnestic effectors and maximizes memory CD8+ T cell quantity but reportedly erodes proliferative potential and protective efficacy. This study exploited heterologou...

journal_title：Immunity

authors： Fraser KA,Schenkel JM,Jameson SC,Vezys V,Masopust D

更新日期：2013-07-25 00:00:00

abstract：:Tumor necrosis factor receptor (TNFR) superfamily members can induce a context-dependent apoptosis or cell activation. However, the mechanisms by which these opposing programs are selected remain unclear. We show that in T cells, TNFR2 (TNFRSF1B) signaling is dramatically affected by the intracellular mediator RIP, a ...

journal_title：Immunity

authors： Pimentel-Muiños FX,Seed B

更新日期：1999-12-01 00:00:00

abstract：:The immunodominant CD4 T cell epitope region, Th2R, of the circumsporozoite protein of Plasmodium falciparum is highly polymorphic. Such variation might be utilized by the parasite to escape from or interfere with CD4 T cell effector functions. Here, we show that costimulation with naturally occurring altered peptide ...

journal_title：Immunity

authors： Plebanski M,Flanagan KL,Lee EA,Reece WH,Hart K,Gelder C,Gillespie G,Pinder M,Hill AV

更新日期：1999-06-01 00:00:00

abstract：:We previously reported that the mice deficient for SPA-1, a Rap1 GTPase-activating protein, developed hematopoietic stem cell disorders. Here, we demonstrate that SPA-1(-/-) mice show an age-dependent increase in B220(high) B1a cells producing anti-dsDNA antibody and lupus-like nephritis. SPA-1(-/-) peritoneal B1 cell...

journal_title：Immunity

authors： Ishida D,Su L,Tamura A,Katayama Y,Kawai Y,Wang SF,Taniwaki M,Hamazaki Y,Hattori M,Minato N

更新日期：2006-04-01 00:00:00

abstract：:After acute inflammation or infection, tissue-resident macrophages are replaced by inflammatory DCs and effector macrophages that arise from circulating monocytes. In this issue of Immunity, Goldszmid et al. (2012) demonstrate a central role for NK cell-derived IFN-γ in signaling and facilitating this transition. ...

journal_title：Immunity

authors： Yap GS,Rivera A

更新日期：2012-06-29 00:00:00

abstract：:Reorganization of the actin cytoskeleton requires nucleating factors, which initiate actin fiber formation. In this issue of Immunity, the functions of two classes of actin nucleators are examined in T lymphocytes, giving insight into the regulation of T cell polarity (Gomez et al., 2007). ...

journal_title：Immunity

authors： Schwartzberg PL

更新日期：2007-02-01 00:00:00

abstract：:Galactocerebrosides (GCs) represent a major class of glycolipids in the nervous system. Here, we show that mice lacking the key enzyme to generate GCs, UDP-galactose:ceramide galactosyltransferase (CGT(-/-)), exhibit severe postnatal atrophy of all lymphoid organs, owing to a maturational arrest before the pro-B/T cel...

journal_title：Immunity

authors： Katayama Y,Frenette PS

更新日期：2003-06-01 00:00:00

abstract：:Recognition of bacterial peptidoglycan by the Drosophila IMD pathway triggers NF-κB activation and an associated immune response. In this issue of Immunity, Kleino et al. (2017) show that proteins in the IMD pathway form functional amyloids via a cryptic motif resembling the RHIM motif found in mammalian RIPK proteins...

journal_title：Immunity

authors： Shin S,Cherry S

更新日期：2017-10-17 00:00:00

abstract：:We report essential roles of zinc finger transcription factor Gfi-1 in myeloid development. Gene-targeted Gfi-1(-/-) mice lack normal neutrophils and are highly susceptible to abscess formation by gram-positive bacteria. Arrested, morphologically atypical, Gr1(+)Mac1(+) myeloid cells expand with age in the bone marrow...

journal_title：Immunity

authors： Hock H,Hamblen MJ,Rooke HM,Traver D,Bronson RT,Cameron S,Orkin SH

更新日期：2003-01-01 00:00:00

abstract：:Activated T cells must mediate effector responses sufficiently to clear pathogens while avoiding excessive tissue damage. Here we have combined dynamic intravital microscopy with ex vivo assessments of T cell cytokine responses to generate a detailed spatiotemporal picture of CD4(+) T cell effector regulation in the s...

journal_title：Immunity

authors： Honda T,Egen JG,Lämmermann T,Kastenmüller W,Torabi-Parizi P,Germain RN

更新日期：2014-02-20 00:00:00

abstract：:T cell activation through the TCR can result in either cell proliferation or cell death. The role of costimulatory receptors in regulating T cell survival has not been defined. Here, we present data demonstrating that CD28 costimulation enhances the in vitro survival of activated T cells. One mechanism for this enhanc...

journal_title：Immunity

authors： Boise LH,Minn AJ,Noel PJ,June CH,Accavitti MA,Lindsten T,Thompson CB

更新日期：1995-07-01 00:00:00

abstract：:Ikaros family members play an important role in hematopoietic development. Thompson et al. (2007) show that pre-BCR signaling induces Aiolos expression, which in turn suppresses the expression of the pre-BCR component lambda5 and eliminates the very structure that signaled its appearance. ...

journal_title：Immunity

authors： Kioussis D

更新日期：2007-03-01 00:00:00

abstract：:The kinases RIPK1 and RIPK3 and the pseudo-kinase MLKL have been identified as key regulators of the necroptotic cell death pathway, although a role for MLKL within the whole animal has not yet been established. Here, we have shown that MLKL deficiency rescued the embryonic lethality caused by loss of Caspase-8 or FAD...

journal_title：Immunity

authors： Alvarez-Diaz S,Dillon CP,Lalaoui N,Tanzer MC,Rodriguez DA,Lin A,Lebois M,Hakem R,Josefsson EC,O'Reilly LA,Silke J,Alexander WS,Green DR,Strasser A

更新日期：2016-09-20 00:00:00

abstract：:For a brief period during fetal lymph node organogenesis in mice, lymph node postcapillary high endothelial venules surprisingly express the Peyer's patch addressin MAdCAM-1. This expression allows initial seeding of this incipient structure by two unusual lymphocyte populations selectively expressing the Peyer's patc...

journal_title：Immunity

authors： Mebius RE,Rennert P,Weissman IL

更新日期：1997-10-01 00:00:00

abstract：:Superantigens (SAGs) activate T cells by simultaneously binding the Vbeta domain of the TCR and MHC class II molecules on antigen-presenting cells. The preferential expression of certain Valpha regions among SAG-reactive T cells has suggested that the TCR alpha chain may modulate the level of activation through an int...

journal_title：Immunity

authors： Andersen PS,Lavoie PM,Sékaly RP,Churchill H,Kranz DM,Schlievert PM,Karjalainen K,Mariuzza RA

更新日期：1999-04-01 00:00:00

abstract：:Regulatory T cells (Treg cells) perform suppressive functions in disparate tissue environments and against many inflammatory insults, yet the tissue-enriched factor(s) that influence Treg cell phenotype and function remain largely unknown. We have shown a vital role for transforming growth factor-β (TGF-β) signals in ...

journal_title：Immunity

authors： Konkel JE,Zhang D,Zanvit P,Chia C,Zangarle-Murray T,Jin W,Wang S,Chen W

更新日期：2017-04-18 00:00:00

abstract：:The development, validation, and appropriate application of serological assays to detect antibodies to SARS-CoV-2 are essential to determining seroprevalence of this virus in the United States and globally and in guiding government leadership and the private sector on back-to-work policies. An interagency working grou...

journal_title：Immunity

authors： Lerner AM,Eisinger RW,Lowy DR,Petersen LR,Humes R,Hepburn M,Cassetti MC

更新日期：2020-07-14 00:00:00