Rap1 signal controls B cell receptor repertoire and generation of self-reactive B1a cells.

abstract：:The Toll-like receptor 3 (TLR3) and TLR4-signaling pathway that involves the adaptor protein TRIF activates type I interferon (IFN) and proinflammatory cytokine expression. Little is known about how TRIF pathway-dependent gene expression is regulated. SH2-containing protein tyrosine phosphatase 2 (SHP-2) is a widely e...

journal_title：Immunity

authors： An H,Zhao W,Hou J,Zhang Y,Xie Y,Zheng Y,Xu H,Qian C,Zhou J,Yu Y,Liu S,Feng G,Cao X

更新日期：2006-12-01 00:00:00

abstract：:Destruction of li by proteolysis is required for MHC class II molecules to bind antigenic peptides, and for transport of the resulting complexes to the cell surface. The cysteine protease cathepsin S is highly expressed in spleen, lymphocytes, monocytes, and other class II-positive cells, and is inducible with interfe...

journal_title：Immunity

authors： Riese RJ,Wolf PR,Brömme D,Natkin LR,Villadangos JA,Ploegh HL,Chapman HA

更新日期：1996-04-01 00:00:00

abstract：:Effector CD8(+) T cells scan tissues to locate and kill infected host cells. In this issue of Immunity, Hickman et al. (2015) show that the exploration is not random: infected monocytes attract their assassins by secreting chemokines, which accelerates clearance of epicutaneous vaccinia virus infection. ...

journal_title：Immunity

authors： Beura LK,Masopust D

更新日期：2015-03-17 00:00:00

abstract：:Cyclophilin A (CypA/Ppia) is a peptidyl-prolyl isomerase (PPIase) that binds the immunosuppressive drug cyclosporine. The resulting complex blocks T cell function by inhibiting the calcium-dependent phosphatase calcineurin. To identify the native function of CypA, long suspected of regulating signal transduction, we g...

journal_title：Immunity

authors： Colgan J,Asmal M,Neagu M,Yu B,Schneidkraut J,Lee Y,Sokolskaja E,Andreotti A,Luban J

更新日期：2004-08-01 00:00:00

abstract：:The Toll-like receptor 9 (TLR9) is activated by DNA presented in acidified, intracellular compartments. Previous studies suggested that signaling required unmethylated CpG dinucleotides, but in this issue of Immunity, Haas et al. (2008) challenge this view, showing that DNA can activate TLR9 in a sequence-independent ...

journal_title：Immunity

authors： Gangloff M,Gay NJ

更新日期：2008-03-01 00:00:00

abstract：:CXCR5, the receptor for B lymphocyte chemoattractant (BLC), is required for normal development of Peyer's patches, inguinal lymph nodes, and splenic follicles. To test the in vivo activity of BLC in isolation of other lymphoid organizers, transgenic mice were generated expressing BLC in the pancreatic islets. In addit...

journal_title：Immunity

authors： Luther SA,Lopez T,Bai W,Hanahan D,Cyster JG

更新日期：2000-05-01 00:00:00

abstract：:Selectins play a central role in leukocyte trafficking by mediating tethering and rolling on vascular surfaces. Here we have reported that T cell immunoglobulin and mucin domain 1 (TIM-1) is a P-selectin ligand. We have shown that human and murine TIM-1 binds to P-selectin, and that TIM-1 mediates tethering and rollin...

journal_title：Immunity

authors： Angiari S,Donnarumma T,Rossi B,Dusi S,Pietronigro E,Zenaro E,Della Bianca V,Toffali L,Piacentino G,Budui S,Rennert P,Xiao S,Laudanna C,Casasnovas JM,Kuchroo VK,Constantin G

更新日期：2014-04-17 00:00:00

abstract：:Interleukin-2 (IL-2) and downstream transcription factor STAT5 are important for maintaining regulatory T (Treg) cell homeostasis and function. Treg cells can respond to low IL-2 levels, but the mechanisms of STAT5 activation during partial IL-2 deficiency remain uncertain. We identified the serine-threonine kinase Ms...

journal_title：Immunity

authors： Shi H,Liu C,Tan H,Li Y,Nguyen TM,Dhungana Y,Guy C,Vogel P,Neale G,Rankin S,Feng Y,Peng J,Tao W,Chi H

更新日期：2018-11-20 00:00:00

abstract：:Circulating lymphocytes home to the mucosal lymphoid organs, Peyer's patches (PP), through high endothelial venules (HEV). In situ analyses revealed that transfused lymph node cells (LNCs) interact with PP-HEV in a series of overlapping adhesion events: L-selectin (CD62L) > alpha 4 beta 7 initiates interaction, L-sele...

journal_title：Immunity

authors： Bargatze RF,Jutila MA,Butcher EC

更新日期：1995-07-01 00:00:00

abstract：:Immunoglobulin G (IgG) antibodies confer protection against pathogenic microorganisms, serve as therapeutics in tumor therapy, and are involved in destruction of healthy tissues during autoimmune diseases. Understanding the molecular pathways and effector cell types involved in antibody-mediated effector functions is ...

journal_title：Immunity

authors： Biburger M,Aschermann S,Schwab I,Lux A,Albert H,Danzer H,Woigk M,Dudziak D,Nimmerjahn F

更新日期：2011-12-23 00:00:00

abstract：:Secondary diversification of the B cell repertoire by immunoglobulin gene somatic hypermutation in the germinal center (GC) is essential for providing the high-affinity antibody specificities required for long-term humoral immunity. While the risk to self-tolerance posed by inadvertent generation of self-reactive GC B...

journal_title：Immunity

authors： Chan TD,Wood K,Hermes JR,Butt D,Jolly CJ,Basten A,Brink R

更新日期：2012-11-16 00:00:00

abstract：:The establishment and maintenance of immunological tolerance entails both central and peripheral mechanisms. The latter have been highlighted in the past several years, mostly because of great interest in the activities of regulatory T cells. However, an important role for central tolerance mechanisms has been reempha...

journal_title：Immunity

authors： Mathis D,Benoist C

更新日期：2004-05-01 00:00:00

abstract：:Aryl hydrocarbon receptor (Ahr) is crucial for the maintenance and function of group 3 innate lymphoid cells (ILCs), which are important in gut immunity. Because Ahr promotes T helper 17 (Th17) cell differentiation in vitro, it is reasonable to expect that Ahr would enhance Th17 cells in vivo. Instead, we show that Ah...

journal_title：Immunity

authors： Qiu J,Guo X,Chen ZM,He L,Sonnenberg GF,Artis D,Fu YX,Zhou L

更新日期：2013-08-22 00:00:00

abstract：:The elongated complementary-determining region (CDR) 3beta found in the unliganded KB5-C20 TCR protrudes from the antigen binding site and prevents its docking onto the peptide/MHC (pMHC) surface according to a canonical diagonal orientation. We now present the crystal structure of a complex involving the KB5-C20 TCR ...

journal_title：Immunity

authors： Reiser JB,Grégoire C,Darnault C,Mosser T,Guimezanes A,Schmitt-Verhulst AM,Fontecilla-Camps JC,Mazza G,Malissen B,Housset D

更新日期：2002-03-01 00:00:00

abstract：:The Ikaros gene family encodes zinc finger DNA-binding proteins essential for lineage determination and control of proliferation in the lymphoid system. Here, we report that, in the nucleus of a T cell, a major fraction of Ikaros and Aiolos proteins associate with the DNA-dependent ATPase Mi-2 and histone deacetylases...

journal_title：Immunity

authors： Kim J,Sif S,Jones B,Jackson A,Koipally J,Heller E,Winandy S,Viel A,Sawyer A,Ikeda T,Kingston R,Georgopoulos K

更新日期：1999-03-01 00:00:00

abstract：:Recent experiments have suggested that tumor necrosis factor alpha (TNFalpha) can down-regulate islet-specific T cells and prevent the development of autoimmune diabetes. Here we demonstrate that transgenic mice expressing both TNFalpha and the Leishmania major LACK antigen in the pancreas (RIP-TNFalpha/RIP-LACK) exhi...

journal_title：Immunity

authors： McSorley SJ,Soldera S,Malherbe L,Carnaud C,Locksley RM,Flavell RA,Glaichenhaus N

更新日期：1997-09-01 00:00:00

abstract：:Mutations in the IL23R gene are linked to inflammatory bowel disease susceptibility. Experimental models have shown that interleukin-23 (IL-23) orchestrates innate and T cell-dependent colitis; however, the cell populations it acts on to induce intestinal immune pathology are unknown. Here, using Il23r(-/-) T cells, w...

journal_title：Immunity

authors： Ahern PP,Schiering C,Buonocore S,McGeachy MJ,Cua DJ,Maloy KJ,Powrie F

更新日期：2010-08-27 00:00:00

abstract：:Activation-induced cytidine deaminase (AID) is required for immunoglobulin (Ig) gene class switch recombination (CSR), somatic hypermutation (SHM), and somatic hyperconversion. In general, high AID expression is found in mature B cells that are responding to antigens. However, AID expression and SHM have also been det...

journal_title：Immunity

authors： Han JH,Akira S,Calame K,Beutler B,Selsing E,Imanishi-Kari T

更新日期：2007-07-01 00:00:00

abstract：:The TNF-related apoptosis-inducing ligand (TRAIL) offers great promise as a cancer therapeutic. Initially, soluble recombinant versions of the TRAIL molecule have exhibited specific tumoricidal activity against a variety of tumors alone, or in combination with other cancer treatments, and much anticipation awaits the ...

journal_title：Immunity

authors： Smyth MJ,Takeda K,Hayakawa Y,Peschon JJ,van den Brink MR,Yagita H

更新日期：2003-01-01 00:00:00

abstract：:Fibroblasts are major contributors to and regulators of inflammation and dominant producers of interleukin-6 (IL-6) in inflammatory diseases like rheumatoid arthritis. Yet, compared to leukocytes, the regulation of inflammatory pathways in fibroblasts is largely unknown. Here, we report that analyses of genes coordina...

journal_title：Immunity

authors： Nguyen HN,Noss EH,Mizoguchi F,Huppertz C,Wei KS,Watts GFM,Brenner MB

更新日期：2017-02-21 00:00:00

abstract：:We have investigated the lymphohematopoietic potentials of endothelial cells (EC) and hematopoietic cells (HPC) sorted from embryos. Expression of VE-cadherin, CD45, and Ter119 was used to distinguish EC (VE-cadherin+CD45-Ter119-) from HPC (VE-cadherin-CD45+). Thus defined, EC population takes up acetylated LDL and co...

journal_title：Immunity

authors： Nishikawa SI,Nishikawa S,Kawamoto H,Yoshida H,Kizumoto M,Kataoka H,Katsura Y

更新日期：1998-06-01 00:00:00

abstract：:How is the amoeboid movement of lymphocytes in secondary lymphoid organs orchestrated? In this issue of Immunity, Bajénoff et al. (2006) demonstrate that stromal cell networks serve as guidance structures that direct and limit the migration of B and T cells in lymph nodes. ...

journal_title：Immunity

authors： Mempel TR,Junt T,von Andrian UH

更新日期：2006-12-01 00:00:00

abstract：:Efficient unidirectional killing by cytotoxic T lymphocytes (CTL) requires translocation of the microtubule organizing center (MTOC) to the target cell contact site. Here we utilize modulated polarization microscopy and computerized 3D reconstruction of tubulin and LFA-1 immunofluorescence images to investigate how th...

journal_title：Immunity

authors： Kuhn JR,Poenie M

更新日期：2002-01-01 00:00:00

abstract：:A cDNA clone encoding the human homolog of rat Jagged1 was isolated from normal human marrow. Analyses of human stromal cell lines indicate that this gene, designated hJagged1, is expressed by marrow stromal cells typified by the cell line HS-27a, which supports the long-term maintenance of hematopoietic progenitor ce...

journal_title：Immunity

authors： Li L,Milner LA,Deng Y,Iwata M,Banta A,Graf L,Marcovina S,Friedman C,Trask BJ,Hood L,Torok-Storb B

更新日期：1998-01-01 00:00:00

abstract：:The heat shock (HS) response is a universal response activated after exposure to various stimuli. The major HS protein (HSP) is the 72 kDa HSP70 with strong homology in different eukaryotic species. We demonstrate that HS treatment of mice leads to a strong induction of HSP70 in several organs and confers significant ...

journal_title：Immunity

authors： Van Molle W,Wielockx B,Mahieu T,Takada M,Taniguchi T,Sekikawa K,Libert C

更新日期：2002-05-01 00:00:00

abstract：:Some endocrine organs are frequent targets of autoimmune attack. Here, we addressed the origin of autoimmune disease from the viewpoint of feedback control. Endocrine tissues maintain mass through feedback loops that balance cell proliferation and removal according to hormone-driven regulatory signals. We hypothesized...

journal_title：Immunity

authors： Korem Kohanim Y,Tendler A,Mayo A,Friedman N,Alon U

更新日期：2020-05-19 00:00:00

abstract：:The Notch2 ligand DL1 is required for marginal zone B cell development. In this issue of Immunity, Tan et al. (2009) show that modification of Notch2 by Fringe enzymes is critical to maturing B cells for accessing DL1 on vascular endothelial cells. ...

journal_title：Immunity

authors： Allman D,Calamito M

更新日期：2009-02-20 00:00:00

abstract：:Elevated inflammation in the female genital tract is associated with increased HIV risk. Cervicovaginal bacteria modulate genital inflammation; however, their role in HIV susceptibility has not been elucidated. In a prospective cohort of young, healthy South African women, we found that individuals with diverse genita...

journal_title：Immunity

authors： Gosmann C,Anahtar MN,Handley SA,Farcasanu M,Abu-Ali G,Bowman BA,Padavattan N,Desai C,Droit L,Moodley A,Dong M,Chen Y,Ismail N,Ndung'u T,Ghebremichael MS,Wesemann DR,Mitchell C,Dong KL,Huttenhower C,Walker BD,Virgi

更新日期：2017-01-17 00:00:00

abstract：:The investigation of gammadelta T cells has identified a rapid lymphoid stress-surveillance response to microbial and nonmicrobial tissue perturbation. In addition to providing local protection, this response provides an immediate source of cytokines, chemokines, and other functions that can substantially affect downs...

journal_title：Immunity

authors： Hayday AC

更新日期：2009-08-21 00:00:00

abstract：:The immunodominant CD4 T cell epitope region, Th2R, of the circumsporozoite protein of Plasmodium falciparum is highly polymorphic. Such variation might be utilized by the parasite to escape from or interfere with CD4 T cell effector functions. Here, we show that costimulation with naturally occurring altered peptide ...

journal_title：Immunity

authors： Plebanski M,Flanagan KL,Lee EA,Reece WH,Hart K,Gelder C,Gillespie G,Pinder M,Hill AV

更新日期：1999-06-01 00:00:00