Abstract:
:The immunodominant CD4 T cell epitope region, Th2R, of the circumsporozoite protein of Plasmodium falciparum is highly polymorphic. Such variation might be utilized by the parasite to escape from or interfere with CD4 T cell effector functions. Here, we show that costimulation with naturally occurring altered peptide ligands (APL) can induce a rapid change from IFNgamma production to the immunosuppressive mediator interleukin 10 (IL-10). This mechanism may contribute to the low levels of T cell responses observed to this pathogen in malaria-endemic areas.
journal_name
Immunityjournal_title
Immunityauthors
Plebanski M,Flanagan KL,Lee EA,Reece WH,Hart K,Gelder C,Gillespie G,Pinder M,Hill AVdoi
10.1016/s1074-7613(00)80064-3keywords:
subject
Has Abstractpub_date
1999-06-01 00:00:00pages
651-60issue
6eissn
1074-7613issn
1097-4180pii
S1074-7613(00)80064-3journal_volume
10pub_type
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