Abstract:
:Membrane recruitment of SHIP is responsible for the inhibitory signal generated by FcgammaRIIB coligation to the BCR. By reducing the level of PIP3, SHIP regulates the association of the tyrosine kinase Btk with the membrane through PH domain-phosphoinositol lipid interactions. Inhibition of BCR signaling by either FcgammaRIIB coligation, membrane expression of SHIP, or inhibition of P13K, conditions which result in decreased levels of PIP3, is suppressed by the expression of Btk as a membrane-associated chimera. Conversely, increasing PIP3 levels by deletion of SHIP results in increased Btk association with the membrane and hyperresponsive BCR signaling. These results suggest a central role for PIP3 in regulating the B cell stimulatory state by modulating Btk localization and thereby calcium fluxes.
journal_name
Immunityjournal_title
Immunityauthors
Bolland S,Pearse RN,Kurosaki T,Ravetch JVdoi
10.1016/s1074-7613(00)80555-5subject
Has Abstractpub_date
1998-04-01 00:00:00pages
509-16issue
4eissn
1074-7613issn
1097-4180pii
S1074-7613(00)80555-5journal_volume
8pub_type
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