The quest for CD8+ memory stem cells.

abstract：:Targeted mutagenesis in mice is a powerful tool for functional analysis of genes. However, genetic variation between embryonic stem cells (ESCs) used for targeting (previously almost exclusively 129-derived) and recipient strains (often C57BL/6J) typically results in congenic mice in which the targeted gene is flanked...

journal_title：Immunity

authors： Vanden Berghe T,Hulpiau P,Martens L,Vandenbroucke RE,Van Wonterghem E,Perry SW,Bruggeman I,Divert T,Choi SM,Vuylsteke M,Shestopalov VI,Libert C,Vandenabeele P

更新日期：2015-07-21 00:00:00

abstract：:Human memory B cells that carry mutated IgV region genes were isolated from tonsils by negative selection of IgD+ naive B cells and CD38+ germinal center B cells and plasma cells. They were mainly found within the intraepithelial areas, but not in the B cell follicles of human tonsils. Memory B cells but not naive B c...

journal_title：Immunity

authors： Liu YJ,Barthélémy C,de Bouteiller O,Arpin C,Durand I,Banchereau J

更新日期：1995-03-01 00:00:00

abstract：:MicroRNA (miRNA)-deficient helper T cells exhibit abnormal IFN-γ production and decreased proliferation. However, the contributions of individual miRNAs to this phenotype remain poorly understood. We conducted a screen for miRNA function in primary T cells and identified individual miRNAs that rescue the defects assoc...

journal_title：Immunity

authors： Steiner DF,Thomas MF,Hu JK,Yang Z,Babiarz JE,Allen CD,Matloubian M,Blelloch R,Ansel KM

更新日期：2011-08-26 00:00:00

abstract：:Neonatal female mice injected with the self ZP3 peptide are not tolerant to the peptide; they develop autoimmune ovarian disease (AOD) and autoantibody response 5 weeks later. ZP3 challenge leads to severe AOD and ZP3-specific T cell and antibody responses. In contrast, neonatal tolerance to foreign ZP3 peptide is est...

journal_title：Immunity

authors： Garza KM,Griggs ND,Tung KS

更新日期：1997-01-01 00:00:00

abstract：:Immunoglobulin A (IgA) is prominently secreted at mucosal surfaces and coats a fraction of the intestinal microbiota. However, the commensal bacteria bound by IgA are poorly characterized and the type of humoral immunity they elicit remains elusive. We used bacterial flow cytometry coupled with 16S rRNA gene sequencin...

journal_title：Immunity

authors： Bunker JJ,Flynn TM,Koval JC,Shaw DG,Meisel M,McDonald BD,Ishizuka IE,Dent AL,Wilson PC,Jabri B,Antonopoulos DA,Bendelac A

更新日期：2015-09-15 00:00:00

abstract：:Following the fate of antigen-specific memory B cells has been difficult. In this issue of Immunity, Krishnamurty et al. (2016) use a novel B cell tetramer to define Plasmodium-specific memory B cells in parasite-infected mice and demonstrate that after re-infection, somatically mutated IgM(+) memory B cells function ...

journal_title：Immunity

authors： Stone SL,Lund FE

更新日期：2016-08-16 00:00:00

abstract：:Distinct metabolic programs support the differentiation of CD4(+) T cells into separate functional subsets. In this study, we investigated metabolic mechanisms underlying the differentiation of IL-9-producing CD4(+) T cells (Th9) in allergic airway inflammation and cancerous tumors. We found that histone deacetylase S...

journal_title：Immunity

authors： Wang Y,Bi Y,Chen X,Li C,Li Y,Zhang Z,Wang J,Lu Y,Yu Q,Su H,Yang H,Liu G

更新日期：2016-06-21 00:00:00

abstract：:The concept of an alternative pathway of macrophage activation has stimulated interest in its definition, mechanism, and functional significance in homeostasis and disease. We assess recent research in this field, argue for a restricted definition, and explore pathways by which the T helper 2 (Th2) cell cytokines inte...

journal_title：Immunity

authors： Gordon S,Martinez FO

更新日期：2010-05-28 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) and cancer stem cells (CSCs) are important cellular components in the cancer microenvironment and may affect cancer phenotype and patient outcome. The nature of MDSCs and their interaction with CSCs in ovarian carcinoma are unclear. We examined the interaction between MDSCs and...

journal_title：Immunity

authors： Cui TX,Kryczek I,Zhao L,Zhao E,Kuick R,Roh MH,Vatan L,Szeliga W,Mao Y,Thomas DG,Kotarski J,Tarkowski R,Wicha M,Cho K,Giordano T,Liu R,Zou W

更新日期：2013-09-19 00:00:00

abstract：:In this issue of Immunity, Chaudhry et al. (2011) and Huber et al. (2011) report that control of Th17 cell responses during colonic inflammation requires direct signaling by IL-10 in regulatory T cells and Th17 cells. ...

journal_title：Immunity

authors： Stewart CA,Trinchieri G

更新日期：2011-04-22 00:00:00

abstract：:By virtue of its ability to couple the BCR to an inhibitory pathway, FcgammaRIIB can potentially determine the fate of B cells upon IgG immune complex engagement. We now provide evidence for FcgammaRIIB as a component of a peripheral tolerance pathway with the observation that RIIB-/- mice develop autoantibodies and a...

journal_title：Immunity

authors： Bolland S,Ravetch JV

更新日期：2000-08-01 00:00:00

abstract：:De Libero et al. (2005) demonstrate in this issue of Immunity that bacterial infection leads to increased synthesis of autologous glycolipids that are recognized by CD1-restricted human T cells, indicating that recognition of inducible self-glycolipids could be a mechanism for microbial detection. This mechanism also ...

journal_title：Immunity

authors： Kronenberg M,Kinjo Y

更新日期：2005-06-01 00:00:00

abstract：:The intestinal microbiota shapes and directs immune development locally and systemically, but little is known about whether commensal microbes in the stomach can impact their immunological microenvironment. Here, we report that group 2 innate lymphoid cells (ILC2s) were the predominant ILC subset in the stomach and sh...

journal_title：Immunity

authors： Satoh-Takayama N,Kato T,Motomura Y,Kageyama T,Taguchi-Atarashi N,Kinoshita-Daitoku R,Kuroda E,Di Santo JP,Mimuro H,Moro K,Ohno H

更新日期：2020-04-14 00:00:00

abstract：:Perforation of membranes and pore formation is mediated by polymerization of proteins of the immune system, complement C9 and Perforin, which share the conserved MACPF domain. In this issue of Immunity, Baran et al. (2009) identify the molecular mechanism initiating polymerization as charge interactions in the MACPF d...

journal_title：Immunity

authors： Podack ER

更新日期：2009-05-01 00:00:00

abstract：:The expression of KIR and CD94:NKG2 receptors was determined for more than 100 natural killer (NK) cell clones obtained from two blood donors who differ in their HLA class I and KIR genes. More than 98% of the clones were inhibited by individual autologous class I allotypes, and every clone was inhibited by the combin...

journal_title：Immunity

authors： Valiante NM,Uhrberg M,Shilling HG,Lienert-Weidenbach K,Arnett KL,D'Andrea A,Phillips JH,Lanier LL,Parham P

更新日期：1997-12-01 00:00:00

abstract：:Adaptor proteins act as conduits to channel upstream signals into downstream effector branches. Two B cell-associated adaptors, Bam32 and Carma1, regulate the ERK, JNK, and NF-kappaB branches of the BCR signaling pathway. Recent studies of Bam32-/- and Carma1-/- mice suggest that each adaptor controls a distinct condu...

journal_title：Immunity

authors： Niiro H,Clark EA

更新日期：2003-11-01 00:00:00

abstract：:Mature T cells comprise two mutually exclusive lineages expressing heterodimeric alpha beta or gamma delta antigen receptors. During development, beta, gamma, and delta genes rearrange before alpha, and mature gamma delta cells arise in the thymus prior to alpha beta cells. The mechanism underlying commitment of immat...

journal_title：Immunity

authors： Wilson A,de Villartay JP,MacDonald HR

更新日期：1996-01-01 00:00:00

abstract：:The mammalian intestinal mucosal surface is continuously exposed to a complex and dynamic community of microorganisms. These microbes establish symbiotic relationships with their hosts, making important contributions to metabolism and digestive efficiency. The intestinal epithelial surface is the primary interface bet...

journal_title：Immunity

authors： Duerkop BA,Vaishnava S,Hooper LV

更新日期：2009-09-18 00:00:00

abstract：:Natural hosts for simian immunodeficiency virus (SIV) can be, and are often naturally, infected with species-specific SIVs, but do not develop acquired immunodeficiency syndrome (AIDS). These natural hosts maintain high SIV viral loads, but avoid immunodeficiency. Elucidating the mechanisms that allow natural hosts to...

journal_title：Immunity

authors： Brenchley JM,Silvestri G,Douek DC

更新日期：2010-06-25 00:00:00

abstract：:Antibody responses develop following SARS-CoV-2 infection, but little is known about their epitope specificities, clonality, binding affinities, epitopes, and neutralizing activity. We isolated B cells specific for the SARS-CoV-2 envelope glycoprotein spike (S) from a COVID-19-infected subject 21 days after the onset ...

journal_title：Immunity

authors： Seydoux E,Homad LJ,MacCamy AJ,Parks KR,Hurlburt NK,Jennewein MF,Akins NR,Stuart AB,Wan YH,Feng J,Whaley RE,Singh S,Boeckh M,Cohen KW,McElrath MJ,Englund JA,Chu HY,Pancera M,McGuire AT,Stamatatos L

更新日期：2020-07-14 00:00:00

abstract：:After acute inflammation or infection, tissue-resident macrophages are replaced by inflammatory DCs and effector macrophages that arise from circulating monocytes. In this issue of Immunity, Goldszmid et al. (2012) demonstrate a central role for NK cell-derived IFN-γ in signaling and facilitating this transition. ...

journal_title：Immunity

authors： Yap GS,Rivera A

更新日期：2012-06-29 00:00:00

abstract：:We analyzed the participation of a predominant B cell clonotype in the anti-arsonate immune response of mice in which Bcl-2 expression was enforced in B cells. Many of the antibodies expressed by the arsonate-induced memory compartment of these mice were "dual-reactive," displaying increased affinity acquired via V re...

journal_title：Immunity

authors： Hande S,Notidis E,Manser T

更新日期：1998-02-01 00:00:00

abstract：:We examined the relationship between cell death and tolerance induction following antigen injection into the anterior chamber of the eye. Our data show that when inflammatory cells undergo apoptosis following infection with HSV-1, tolerance to the virus was observed. In contrast, when cell death was absent due to defe...

journal_title：Immunity

authors： Griffith TS,Yu X,Herndon JM,Green DR,Ferguson TA

更新日期：1996-07-01 00:00:00

abstract：:Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. In this issue of Immunity, Lai et al. (2020) uncover a role for the C-type lectin receptor Clec2d as a sensor of cell death, which directly detects histones released during necro...

journal_title：Immunity

authors： Del Fresno C,Sancho D

更新日期：2020-01-14 00:00:00

abstract：:Among 631 substitutions present in 90 nurse shark immunoglobulin light chain somatic mutants, 338 constitute 2-4 bp stretches of adjacent changes. An absence of mutations in perinatal sequences and the bias for one mutating V gene in adults suggest that the diversification is antigen dependent. The substitutions share...

journal_title：Immunity

authors： Lee SS,Tranchina D,Ohta Y,Flajnik MF,Hsu E

更新日期：2002-04-01 00:00:00

abstract：:Although infections with virulent pathogens often induce a strong inflammatory reaction, what drives the increased immune response to pathogens compared to nonpathogenic microbes is poorly understood. One possibility is that the immune system senses the level of threat from a microorganism and augments the response ac...

journal_title：Immunity

authors： Boyer L,Magoc L,Dejardin S,Cappillino M,Paquette N,Hinault C,Charriere GM,Ip WK,Fracchia S,Hennessy E,Erturk-Hasdemir D,Reichhart JM,Silverman N,Lacy-Hulbert A,Stuart LM

更新日期：2011-10-28 00:00:00

abstract：:CD4(+)CD25(+) immunoregulatory T cells represent a unique lineage of thymic-derived cells that potently suppress both in vitro and in vivo effector T cell function. We analyzed CD4(+)CD25(+) and CD4(+)CD25(-) T cells by DNA microarray, identifying 29 genes differentially expressed in the resting subpopulations, and 77...

journal_title：Immunity

authors： McHugh RS,Whitters MJ,Piccirillo CA,Young DA,Shevach EM,Collins M,Byrne MC

更新日期：2002-02-01 00:00:00

abstract：:The intestinal mucosa promotes T cell responses that might be beneficial for effective mucosal vaccines. However, intestinal resident memory T (Trm) cell formation and function are poorly understood. We found that oral infection with Listeria monocytogenes induced a robust intestinal CD8 T cell response and blocking e...

journal_title：Immunity

authors： Sheridan BS,Pham QM,Lee YT,Cauley LS,Puddington L,Lefrançois L

更新日期：2014-05-15 00:00:00

abstract：:Efficient unidirectional killing by cytotoxic T lymphocytes (CTL) requires translocation of the microtubule organizing center (MTOC) to the target cell contact site. Here we utilize modulated polarization microscopy and computerized 3D reconstruction of tubulin and LFA-1 immunofluorescence images to investigate how th...

journal_title：Immunity

authors： Kuhn JR,Poenie M

更新日期：2002-01-01 00:00:00

abstract：:The identification is made in normal mice of the stages in T cell development at which the rearranged beta chain of the T cell receptor (TCR) is utilized to promote T cell maturation, independent of the TCR alpha chain. In addition, evidence is provided that utilization of beta chains in T cell progenitors does not pr...

journal_title：Immunity

authors： Dudley EC,Petrie HT,Shah LM,Owen MJ,Hayday AC

更新日期：1994-05-01 00:00:00